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leucovorin calcium
An active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | calcium (6S)-folinate calcium folinate CFR citrovorum factor folinate calcium folinic acid Folinic Acid Calcium Salt Pentahydrate Leucovorin LV | |
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| US brand name: | | Wellcovorin | |
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| Foreign brand names: | | Adinepar Calcifolin Calfolex Calinat Cehafolin Citofolin Citrec Cromatonbic Folinico Dalisol Disintox Divical Ecofol Emovis Flynoken A Folaren Folaxin Foliben FOLI-cell Folidan Folidar Folinac Folinoral Folinvit Foliplus Folix Imo Lederfolat Lederfolin Leucosar Rescufolin Rescuvolin Tonofolin | |
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| Abbreviation: | | CF | |
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| Acronyms: | | CF CFR LV | |
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| Chemical structures: | | 5-formyl tetrahydrofolate 5-formyl-5,6,7,8-tetrahydrofolic acid 5-formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amnio]benzoyl]-L-glutamic acid N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]glutamic acid | |
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