Because inflammation is an important part of the atherosclerotic process in adults,
it was included as an independent risk factor for the evidence review, with specific
inflammatory markers identified as outcome measures, as outlined in Appendix A.
Methodology. No systematic reviews, meta-analyses, or randomized controlled trials
(RCTs) that addressed inflammation in children or adolescents were identified. A
small number of RCTs and observational studies included measurement of selected
inflammatory markers, and these were reviewed. The Expert Panel concluded that the
available evidence was not sufficient either to make any statement regarding the
role of inflammation in atherosclerosis, as assessed by measurement of inflammatory
markers in childhood, or to include any recommendation regarding measurement of
inflammatory markers in the pediatric age group.
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