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Evidence-Based Medicine

Current Guidelines Have Limited Applicability to Patients with Comorbid Conditions: A Systematic Analysis of Evidence-Based Guidelines. M. Lugtenberg, J. Burgers, C. Clancy, et al., PLoS, ONE October 2011; 6(10):epub. Assesses the extent to which guidelines address comorbidity and the supporting evidence of recommendations related to comorbidity. (AHRQ 12-R021

GRADE: Assessing the Quality of Evidence for Diagnostic Recommendations. H. Schunemann, A. Oxman, J. Brozek, et al., ACP Journal Club, December 2008; 149(6):JC6-2-JC6-3. Describes a rigorous and transparent approach for grading the quality of research evidence and strength of recommendations that can be used to guide clinical practice. (AHRQ 09-R031)

Grading the Strength of a Body of Evidence when Comparing Medical Interventions—Agency for Healthcare Research and Quality and the Effective Health Care Program. AHRQ Series Paper 5. D. Owens, K. Lohr, D. Atkins, et al., Journal of Clinical Epidemiology; May 2010; 63(5):513-523. Establishes guidance on grading strength of evidence for AHRQ's Evidence-based Practice Center (EPC) program. (AHRQ 10-R070)

Identifying and Using Good Practice Guidelines. K. Lin, D. Slawson, American Family Physician, July 2009; 80(1):67-69. Discusses the attributes of "good" practice guidelines and the evidence that should be considered by guideline developers. (AHRQ 09-R079)

Importance of Recommendations for Gestational Weight Gain. C. Kelly, C. Clancy, Journal of Nursing Care Quality, April-June 2009; 24(2):96-99. Discusses the availability of new evidence that reinforces the importance of counseling women about the need to follow established recommendations for weight gain during pregnancy. (AHRQ 09-R085)

Will It Work Here? A Decisionmakers Guide to Adopting Innovations. Agency for Healthcare Research and Quality, September 2008, 116 pp. Helps decisionmakers determine whether an innovation would be a good fit for their health care organizations. (AHRQ 08-0051)

Technical Reviews

Nutritional Research Series. Agency for Healthcare Research and Quality and Office of Dietary Supplements. A series of technical reviews that explore the challenges involved in conducting nutrition-related reviews and integrating the reviews into nutrition applications.

Advancing the Role of Systematic Reviews in Nutrition Research and Applications, Volume 1. Technical Review 17-1, January 2009, 27 pp. Describes the steps for performing systematic reviews and highlights areas unique to the discipline of nutrition important to consider in data assessment. (AHRQ 09-0026-1)

Issues and Challenges in Conducting Systematic Reviews to Support Development of Nutrient Reference Values, Workshop Summary, Volume 2. Technical Review 17-2, January 2009, 45 pp. Using vitamin A as an example, discusses the utility of an unbiased systematic review of a defined question. (AHRQ 09-0026-2)

Reporting of Systematic Reviews of Micronutrients and Health: A Critical Appraisal, Volume 3. Technical Review 17-3. Discusses the reporting of nutrition variables and the importance of improved adherence to consensus methods and reporting standards. (AHRQ 09-0026-3)

More publications in AHRQ's Technical Review series are available online only at http://www.ahrq.gov/clinic/epc/epcseries.htm#Tech.

Evidence Reports/Technology Assessments

Cancer and Blood Disorders

Alcohol Consumption and Cancer Risk: Understanding Possible Causal Mechanisms for Breast and Colorectal Cancers.
Evidence Report/Technology Assessment No. 197.
Evidence Report. November 2010 (AHRQ 11-E003)

Clinical Utility of Cancer Family History Collection in Primary Care.
Evidence Report/Technology Assessment No. 179.
Evidence Report. May 2009 (AHRQ 09-E007)

Diagnosis and Management of Ductal Carcinoma in Situ.
Evidence Report/Technology Assessment No. 185.
Evidence Report. August 2009 (AHRQ 09-E018)

Enhancing the Use and Quality of Colorectal Cancer Screening.
Evidence Report/Technology Assessment No. 190.
Evidence Report. February 2010 (AHRQ 10-E002)

An Evidence Review of Active Surveillance in Men with Localized Prostate Cancer.
Evidence Report/Technology Assessment No. 204.
Executive Summary. December 2011 (AHRQ 12-E003-1)

Family History and Improving Health.
Evidence Report/Technology Assessment No. 186.
Evidence Report. August 2009 (AHRQ 09-E016)

Family History of Breast, Ovarian, Prostate, and Colorectal Cancers.
Evidence Report/Technology Assessment No. 179.
Evidence Report. March 2009 (AHRQ 09-E007)

HER2 Testing to Manage Patients with Breast Cancer or Other Solid Tumors.
Evidence Report/Technology Assessment No. 172.
Evidence Report. November 2008 (AHRQ 09-E001)

Complementary and Alternative Care

Complementary and Alternative Medicine in Back Pain Utilization Report.
Evidence Report/Technology Assessment No. 177.
Evidence Report. February 2009 (AHRQ 09-E006)

Complementary and Alternative Therapies for Back Pain II.
Evidence Report/Technology Assessment No. 194.
Evidence Report. October 2010 (AHRQ 10(11)-E007)

Dietary Supplements

Safety of Probiotics to Reduce Risk and Prevent or Treat Disease.
Evidence Report/Technology Assessment No. 200.
Executive Summary. April 2011 (AHRQ 11-E007-1)

Vitamin D and Calcium: A Systematic Review of Health Outcomes.
Evidence Report/Technology Assessment No. 183.
Evidence Report. August 2009 (AHRQ 09-E015)

Ear, Nose, and Throat Conditions

Exercise-Induced Bronchoconstriction and Asthma.
Evidence Report/ Technology Assessment No. 189
Evidence Report. January 2010 (AHRQ 10-E001)

Management of Acute Otitis Media: Update.
Evidence Report/Technology Assessment No. 198.
Evidence Report. December 2010 (AHRQ 11-E004)

Heart and Vascular Diseases

Diagnosis and Treatment of Erectile Dysfunction.
Evidence Report/Technology Assessment No. 171.
Evidence Report. June 2009 (AHRQ 09-E016)

Outcomes of Genetic Testing in Adults with a History of Venous Thromboembolism.
Evidence Report/Technology Assessment No. 180.
Evidence Report. July 2009 (AHRQ 09-E011)

Transition of Care for Acute Stroke and Myocardial Infarction Patients: From Hospitalization to Rehabilitation, Recovery, and Secondary Prevention.
Evidence Report/Technology Assessment No. 202.
Executive Summary. October 2011 (AHRQ 11(12)-E011-1)

Infectious Diseases

Management of Chronic Hepatitis B.
Evidence Report/Technology Assessment No. 174.
Evidence Report. October 2008 (AHRQ 09-E002)

Information Technology

Barriers and Drivers of Health Information Technology Use for the Elderly, Chronically Ill, and Underserved.
Evidence Report/Technology Assessment No. 175.
Evidence Report. November 2008 (AHRQ 09-E004)

Enabling Medication Management Through Health Information Technology.
Evidence Report/Technology Assessment No. 201.
Executive Summary. April 2011 (AHRQ 11-E008-1)

Impact of Consumer Health Informatics Applications.
Evidence Report/Technology Assessment No. 187.
Evidence Report. August 2009 (AHRQ 09-E019)

Laboratory Testing

Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-Based Drugs.
Evidence Report/Technology Assessment No. 196.
Evidence Report. December 2010 (AHRQ 11-E002)

Mental Health Conditions and Substance Abuse

Integration of Mental Health/Substance Abuse and Primary Care.
Evidence Report/Technology Assessment No. 173.
Evidence Report. December 2008 (AHRQ 09-E003)

Preventing Alzheimer's Disease and Cognitive Decline.
Evidence Report/Technology Assessment No. 193.
Evidence Report. July 2010 (AHRQ 10-E005)

Musculoskeletal Disorders

Treatment of Common Hip Fractures.
Evidence Report/Technology Assessment No. 182.
Evidence Report. June 2009 (AHRQ 09-E009) Available online only (http://www.ahrq.gov/clinic/epcix.htm)

Obstetric and Gynecologic Conditions

Inhaled Nitric Oxide in Preterm Infants.
Evidence Report/Technology Assessment No. 195.
Evidence Report. October 2010 (AHRQ 11-E001)

Maternal and Neonatal Outcomes of Elective Induction of Labor.
Evidence Report/Technology Assessment No. 176.
Evidence Report. December 2008 (AHRQ 09-E005)

Treatment of Overactive Bladder in Women.
Evidence Report/Technology Assessment No. 185.
Evidence Report. September 2009 (AHRQ 09-E017)

Vaginal Birth After Cesarean: New Insights.
Evidence Report/Technology Assessment No. 191.
Evidence Report. March 2010 (AHRQ 10-E001)

Oral and Gastrointestinal Disorders

Lactose Intolerance and Health.
Evidence Report/Technology Assessment No. 192.
Evidence Report. February 2010 (AHRQ 10-E004)

Quality Improvement and Patient Safety

Health Literacy Interventions and Outcomes: An Updated Systematic Review.
Evidence Report/Technology Assessment No. 199.
Executive Summary. March 2011 (AHRQ 11-E006-1)

A complete list of Evidence Reports/Technology Assessments, is available on the AHRQ Web site at http://www.ahrq.gov/clinic/epcix.htm.

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