Nature Genetics - Current issue : December 2012 - Vol 44 No 12
Latest highlights
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Panda genomes
Letter by Shancen ZhaoFuwen Wei, Jun Wang and colleagues report whole-genome sequencing of 34 wild giant pandas. Their population genetics analysis provides insights into demographic history and local adaptation.
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Genetics of maize oil biosynthesis
Article by Hui LiJianbing Yan, Jiansheng Li, Guoying Wang and colleagues report a genome-wide association study in maize for maize kernel oil composition.
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Genomics of epidemic Clostridium difficile
Letter by Miao HeTrevor Lawley, Julian Parkhill and colleagues report whole-genome sequencing of a large global collection of C. difficile. Their phylogenetic analysis traces the spread of this pathogen through healthcare-associated epidemics worldwide.
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SETBP1 and atypical chronic myeloid leukemia
Article by Rocco Piazza, Simona VallettaCarlo Gambacorti-Passerini and colleagues identify recurrent SETBP1 mutations in atypical chronic myeloid leukemia. The mutations, which cluster in a small region of SETBP1, are associated with high white blood cell counts and poor prognosis.
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Dclk1 and tumor stem cells
Letter by Yuki NakanishiHiroshi Seno and colleagues report that Dclk1 selectively marks intestinal tumor stem cells. They further show that specific ablation of these cells in a mouse tumor model results in a pronounced regression of polyps without apparent damage to normal intestinal tissue.
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H3K9 methylation and iPSC reprogramming
Article by Jiekai Chen, He LiuDuanqing Pei and colleagues show that BMP signaling to H3K9 methylation is a barrier to reprogramming somatic cells into induced pluripotent cells (iPSCs) and that its removal promotes the formation of fully reprogrammed iPSCs from pre-iPSCs.
