Chronic Neurogenic Pain Responds to URB937

Chronic Neurogenic Pain Responds to URB937 Seven days after having their sciatic nerve surgically exposed and tied, mice received either an inert substance or URB937. Two hours later, those that received 3 mg/kg of the FAAH inhibitor showed no more sensitivity to radiant heat (Withdrawal Threshold) or pressure from a glass cylinder (Withdrawal Latency) than control animals whose nerves were not tied (Sham).

Top diagram: Bar graph compares how long mice with simulated chronic neurogenic pain took to withdraw their paws from a hot surface when untreated and when treated with four doses of URB937. The more URB937 animals received, the longer they left their paws on the surface, from a minimum of 10 seconds (untreated) to a maximum of 45 seconds (3.0 mg/kg).

Bottom diagram: Bar graph compares how long mice with simulated chronic neurogenic pain took to withdraw their paws from a radiant heat source when untreated and when treated with four doses of URB937. The more URB937 animals received, the longer they left their paws on the surface, from a minimum of 15 seconds (untreated) to a maximum of 48 seconds (3.0 mg/kg).

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