What are the advantages of making the
KOMP resource?
A significant number of the 25,000 mouse genes (about 3200)
have been knocked out and published. However, many published mice are
not readily available to the scientific community (e.g., only 740 unique
genes are represented as targeted mutations in the International Mouse
Strain Resource). The reason for the restricted availability of these
mice is that they have been generated either in individual laboratories
or as commercial efforts, and not as a public resource. The limited
availability of the mice force a redundancy in production – a single
mouse gene is knocked out on average 2.5 times – which presents a large
financial burden for the entire biomedical research community. Collaborating
with existing efforts, nationally and internationally, as well as centralizing
the process of making new mutants will capitalize on efficiencies of
scale. This will save time and dollars down the road; insure
that mice are made available for researchers at relatively low costs
and in a timely fashion; completely mutagenize the whole genome more
quickly than in the current one-off fashion; and possibly create a
platform for normalizing down stream phenotypic analyses. No
longer would a researcher need to invest large sums of grant dollars
into generating these reagents, nor run the risk of losing one to two
years of research effort if the attempt fails, but could invest the
savings in detailed characterization of the mutant mouse and other
data generating experiments. |