Key treatments for high blood pressure and high blood lipids do not reduce elderly patients' risk of limited mobility
Use of angiotensin-converting enzyme (ACE) inhibitors
and statins do not reduce the risk of impaired mobility
in older adults, a new study finds. Impairments in
mobility are common in older adults, with 15 percent
of older men and 23 percent of older women unable to
walk two to three blocks. Chronic inflammation, which
can lead to several health problems and age-related
muscle loss, has been identified as a factor leading to a
decline in functional status, including mobility. Both
ACE inhibitors and statins—drugs used to treat high
blood pressure and high cholesterol/lipid levels,
respectively—may decrease systemic inflammation. In
addition, ACE inhibitors may have a direct effect on
muscle mass.
To see if these medications would indirectly have a
positive impact on mobility, the researchers followed
3,055 healthy older adults, who had no mobility
problems at baseline, for 6.5 years. At baseline, the
participants were in their 70s and had no difficulty
walking a quarter-mile, climbing 10 steps, or
performing basic activities of daily living; 15.2 percent
used ACE inhibitors and 12.9 percent used statins. By
Year 6, ACE inhibitor use had increased to 25.6 percent
and statin use to 28.6 percent.
At the end of the 6.5-year study, 49.8 percent of the
remaining adults had developed mobility limitation. In
separate multivariable models, neither ACE inhibitor
use nor statin use was significantly associated with
lower risk of mobility limitation. The study was funded
in part by the Agency for Healthcare Research and
Quality (HS17695, HS18721, and HS19461).
More details are in "Angiotensin-converting enzyme
inhibitor and statin use and incident mobility limitation
in community-dwelling older adults: The Health, Aging
and Body Composition Study," by Shelly L. Gray,
Pharm.D., M.S., Robert M. Boudreau, Ph.D., Anne B.
Newman, M.D., M.P.H., and others in the December
2011 Journal of the American Geriatrics Society
59(12), pp. 2226-2232.
— DIL
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