Trans-NIH Mouse Initiative

Mouse Image

NIH Knockout Mouse Project (KOMP)
* NIH Knockout Mouse Project (KOMP)


Other related projects:

The Mouse Transcriptome Project:

The Mouse Transcriptome Project is an NIH initiative that is generating a free, public database of gene transcripts for many mouse tissues. Currently, transcriptome data are available on more than 90 tissue samples. These tissue-specific expression data, which are mapped to the mouse genome, are available in a searchable format in the Mouse Reference Transcriptome Database and at the Mouse Reference Transcriptome .

The mouse was chosen for this effort because its genome has been sequenced, because its tissues can be obtained under rigorous quality control conditions, and because of its importance as a model for the study of human biology and disease. For more information and a description of transcriptomes, see http://www.genome.gov/13014330#6 .

The Mammalian Gene Collection

The Mammalian Gene Collection is a National Institutes of Health (NIH) initiative that is building a collection of copies of human, mouse and rat mRNA sequences in a form called complementary DNA (cDNA) clones. The project, which is co-led by NHGRI and the National Cancer Institute, is well over half of the way to its goal of providing at least one cDNA clone for every known human and mouse gene.

Researchers can view the cDNA sequence data in a free, public database located at the Mammalian Gene Collection . They can also order copies of these cDNA clones and then insert them into bacterial or mammalian cells, causing the cells to synthesize the proteins encoded by that particular gene transcript. This enables researchers to study the protein's properties in greater detail, as well as to examine the effects that the protein and mutant versions of the protein may have on various cell types.