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diazoxide
A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release by interacting with ATP-sensitive potassium channels of pancreatic islet beta-cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand name: | | Proglycem | |
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| Code name: | | SRG-95213 | |
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| Chemical structure: | | 3-methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide | |
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