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penicillamine
A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | Depamine D-mercaptovaline D-Penicillamine | |
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| US brand names: | | Cuprenil Cuprimine Depen Perdolat Sufortan | |
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| Foreign brand names: | | Atamir Cupripen Distamine Kelatin Mercaptyl Metalcaptase Pendramine Trolovol | |
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| Chemical structures: | | 3-mercapto-D-valine alpha-amino-beta-methyl-beta-mercaptobutyric acid beta,beta-dimethylcysteine beta-thiovaline | |
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