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busulfan
A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | BSF Bussulfam Busulfanum busulphan glyzophrol methanesulfonic acid, tetramethylene ester Myeleukon Myeloleukon Myelosan Mylecytan Sulfabutin tetramethylene bis(methanesulfonate) | |
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| US brand names: | | Busulfex Mitosan Myleran | |
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| Foreign brand names: | | Mielucin Misulban Misulfan | |
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| Abbreviations: | | BU BUS | |
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| Code names: | | CB-2041 GT-41 WR-19508 | |
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| Chemical structures: | | 1,4-bis(methanesulfonoxy)butane 1,4-bitanediol dimethanesulfonate esters 1,4-butanediol dimethylsulfonate 1,4-di(methanesulfonyloxy)butane 1,4-di(methylsulfonyloxy)butane | |
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