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CB10-277
A synthetic derivative of dimethylphenyl-triazene related to dacarbazine, with antineoplastic properties. Related to the agent dacarbazine, CB10-277 is converted in vivo to a monomethyl triazene form that alkylates DNA, resulting in inhibition of DNA replication and repair; in addition, this agent may act as a purine analogue, resulting in inhibition of DNA synthesis, and may interact with protein sulfhydryl groups. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Chemical structure: | | 1-p-carboxy-3,3-dimethylphenyltriazine | |
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