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trilostane
A synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex, resulting in the decreased synthesis of mineralocorticoids and glucocorticoids and the decreased conversion of pregnenolone to progesterone. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand name: | | Modrastane | |
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| Foreign brand names: | | Desopan Modrenal | |
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| Code names: | | WIN 24,540 WIN 24540 | |
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| Chemical structures: | | (4Alpha,5alpha,17beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile 2Alpha-cyano-4alpha,5alpha-epoxyandrostan-17beta-ol-3-one 4,5-Epoxy-17-hydroxy-3-oxoandrostane-2-carbonitrile | |
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