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methotrexate
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | alpha-methopterin amethopterin Methotrexatum methylaminopterin Metotrexato | |
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| US brand names: | | Abitrexate Folex Folex PFS Methotrexate LPF Mexate Mexate-AQ | |
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| Foreign brand names: | | Brimexate Emtexate Emthexat Emthexate Farmitrexat Fauldexato Lantarel Ledertrexate Lumexon Maxtrex Medsatrexate Metex Methoblastin Metrotex Novatrex Texate Tremetex Trexeron Trixilem | |
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| Abbreviation: | | MTX | |
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| Code names: | | CL-14377 WR-19039 | |
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| Chemical structures: | | 4-amino-10-methylfolic acid 4-amino-4-deoxy-10-methylpteroyl-L-glutamic acid N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid | |
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