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phentolamine mesylate
The mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand names: | | Regitine Vasomax | |
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| Abbreviation: | | PTM | |
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| Chemical structure: | | m-[N-(2-Imidazolin-2-ylmethyl)-p-toluidino]phenol monomethanesulfonate | |
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