In English | En español
Questions About Cancer? 1-800-4-CANCER

NCI Drug Dictionary


diclofenac sodium gel 
A gel formulation of the sodium salt of diclofenac, a nonsteroidal benzeneacetic acid derivative with analgesic, antipyretic and anti-inflammatory activities. Diclofenac binds to and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid (AA) to pro-inflammatory prostaglandins. This agent may also inhibit lipoxygenases, resulting in the inhibition of pro-inflammatory leukotriene synthesis from AA. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Solaraze