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R(+)XK469
The R-isomer of a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | XK469 | |
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| Chemical structures: | | 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid propanoic acid, 2-[4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}-, (+ )-(R)- | |
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