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sulindac
A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym: | Sulindac Sulfoxide | ||
US brand names: | Aflodac Clinoril | ||
Foreign brand names: | Algocetil Apo-Sulin Arthrocine Artribid Citireuma Clisundac Imbaral Novo-Sundac Reumofil Reumyl Sudac Sulinol Sulreuma | ||
Abbreviation: | SULIN | ||
Code name: | MK-231 | ||
Chemical structures: | (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid | ||