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RFA on Mouse Metabolic Phenotyping Centers for Models of Diabetes and its Complications The National Institute of Diabetes and Digestive Diseases (NIDDK) is soliciting applications to establish national centers for the purpose of detailed metabolic phenotyping of knock-out mice and other mouse models potentially useful for understanding diabetes, its complications, obesity and related metabolic diseases or conditions. These facilities are expected to provide a range of standardized procedures to characterize metabolism, body composition, feeding behavior, activity, tissue pathology, and other physiologic, anatomic or pathological alterations that may occur in these mice. Because the mice to be characterized will have been developed on a variety of genetic backgrounds, characterization must be applicable to the major mouse strains used for research. The user group for these centers is expected to be NIH grantees and others, both inside and outside the institution, who wish to submit their various mice for detailed metabolic and physiologic phenotyping beyond what would be possible or cost-effective in their individual laboratories. Applicants should propose plans to prioritize use of the facility and for cost recovery from users. Coordination among the Mouse Metabolic Phenotyping Centers established in response to this Request for Applications will be required. Finally, Centers are expected to develop improved methods to characterize the mice using a Pilot and Feasibility Project mechanism. This RFA will use the National Institutes of Health (NIH) cooperative agreement (U24) award mechanism. The NIDDK intends to commit approximately $3,000,000 in FY 2001 to fund up to 4 new cooperative agreements in response to this RFA. An applicant may request a project period of up to 5 years and a budget for direct costs of up to $750,000 per year. Letters of Intent are due June 12, 2000. The application receipt date is July 12, 2000. The full text of this RFA can be found at: |
