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RFA on Phenotypic Characterization
of Sleep in Mice
The primary goal of RFA is to advance our understanding of sleep
and wakefulness by developing improved molecular, cellular, and
systems approaches to investigate sleep and circadian phenotypes
in mice. Better and more extensively-characterized mouse models
should help in determining the genetic underpinnings of sleep and
wakefulness, elucidating the physiological role of sleep, and developing
new directions for the treatment of sleep disorders. Establishing
inbred mice strains as a platform for sleep studies will facilitate
the use of targeted and transgenic gene modification approaches
in sleep research, lead to a refinement in the definition of sleep
state in molecular and genomic terms, and advance our understanding
of normal sleep phenotypes.
Additional information about this RFA can be found at
http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-99-001.htm
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