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dabrafenib
An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | BRAF inhibitor GSK2118436 | |
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| Code name: | | GSK2118436 | |
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