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Magnesium


What is it?

Magnesium is a mineral that is present in relatively large amounts in the body. Researchers estimate that the average person’s body contains about 25 grams of magnesium, and about half of that is in the bones. Magnesium is important in more than 300 chemical reactions that keep the body working properly. People get magnesium from their diet, but sometimes magnesium supplements are needed if magnesium levels are too low. Dietary intake of magnesium may be low, particularly among women.

An easy way to remember foods that are good magnesium sources is to think fiber. Foods that are high in fiber are generally high in magnesium. Dietary sources of magnesium include legumes, whole grains, vegetables (especially broccoli, squash, and green leafy vegetables), seeds, and nuts (especially almonds). Other sources include dairy products, meats, chocolate, and coffee. Water with a high mineral content, or “hard” water, is also a source of magnesium.

People take magnesium to prevent or treat magnesium deficiency. Magnesium deficiency is not uncommon in the US. It’s particularly common among African Americans and the elderly.

Magnesium is also used as a laxative for constipation and for preparation of the bowel for surgical or diagnostic procedures. It is also used as an antacid for acid indigestion.

Some people use magnesium for diseases of the heart and blood vessels including chest pain, irregular heartbeat, high blood pressure, high levels of “bad” cholesterol called low-density lipoprotein (LDL) cholesterol, low levels of “good” cholesterol called high-density lipoprotein (HDL) cholesterol, heart valve disease (mitral valve prolapse), and heart attack.

Magnesium is also used for treating attention deficit-hyperactivity disorder (ADHD), anxiety, chronic fatigue syndrome (CFS), Lyme disease, fibromyalgia, leg cramps during pregnancy, diabetes, kidney stones, migraine headaches, weak bones (osteoporosis), premenstrual syndrome (PMS), altitude sickness, urinary incontinence, restless leg syndrome, asthma, hayfever, multiple sclerosis, and for preventing hearing loss.

Athletes sometimes use magnesium to increase energy and endurance.

Some people put magnesium on their skin to treat infected skin ulcers, boils, and carbuncles; and to speed up wound healing. Magnesium is also used as a cold compress in the treatment of a severe skin infection caused by strep bacteria (erysipelas) and as a hot compress for deep-seated skin infections.

Some companies that manufacturer magnesium/calcium combination supplements promote a 2:1 or 3:1 ratio as being ideal for absorption of these elements. However, there is no credible research to support this claim. Claims that coral calcium products have ideal combinations of magnesium and calcium to cure a variety of diseases and conditions are being carefully evaluated by the US Food and Drug Administration (FDA) and US Federal Trade Commission (FTC).

How effective is it?

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for MAGNESIUM are as follows:

Effective for...

  • Dyspepsia (heartburn or “sour stomach”) as an antacid. Various magnesium compounds are used. Magnesium hydroxide seems to work the fastest.
  • Preventing and treating magnesium deficiency, and certain conditions related to magnesium deficiency.
  • Use as a laxative for constipation or preparation of the bowel for surgical or diagnostic procedures.

Likely effective for...

  • Conditions that occur during pregnancy called pre-eclampsia or eclampsia. Magnesium must be given intravenously (by IV) or as a shot. This must be done your healthcare provider.
  • A type of irregular heartbeat called torsades de pointes. Magnesium must be given intravenously (by IV). This must be done your healthcare provider.

Possibly effective for...

  • Premenstrual syndrome (PMS). Taking magnesium seems to relieve symptoms of PMS including mood changes and bloating in some women. Taking magnesium by mouth also seems to prevent premenstrual migraine.
  • Weak bones (osteoporosis). There is evidence that suggests taking magnesium might prevent bone loss in older women who have osteoporosis. There is also evidence that taking estrogen along with magnesium plus calcium and a multivitamin supplement daily increases bone strength better than estrogen alone in older women.
  • Preventing type 2 diabetes in overweight, middle-aged women, when magnesium is obtained from foods. More evidence is needed to know if magnesium helps treat diabetes.
  • Diseases of heart valves (mitral valve prolapse). Taking magnesium seems to reduce symptoms of mitral valve prolapse in people with low magnesium levels in their blood.
  • High cholesterol. There is some evidence that taking magnesium chloride and magnesium oxide can produce small decreases in low-density lipoprotein (LDL) and total cholesterol levels, and small increases in high-density lipoprotein (HDL) levels.
  • Chest pain (angina) due to artery disease. Taking magnesium seems to reduce pain attacks in people with coronary artery disease.
  • Kidney stones. Taking magnesium seems to prevent the recurrence of kidney stones, but other medications such as chlorthalidone (Hygroton) may be more effective.
  • Hearing loss in people exposed to loud noise. Taking magnesium seems to prevent hearing loss in individuals exposed to loud noise.
  • Metabolic syndrome (a condition that increases risk for diabetes and heart disease). People with low serum magnesium levels are 6-7 times more likely to have metabolic syndrome than people with normal magnesium levels. Higher magnesium intake from diet and supplements is linked with a 27% lower risk of developing metabolic syndrome in healthy women and a 31% lower risk in healthy young adults.
  • Preventing stroke. There is some evidence that getting more magnesium from the diet might decrease the risk of stroke in men. However, there is no proof that taking magnesium supplements has this same effect.
  • Chronic fatigue syndrome (CFS), when given by an injection (shot). This must be done by a healthcare provider.
  • Fibromyalgia pain, when used with malic acid.
Possibly Effective when given intravenously (by IV) by a healthcare provider for...
  • Cluster headaches.
  • Migraine headaches.
  • Irregular heartbeat (arrhythmia).
  • Asthma attacks.
  • Nerve pain caused by cancer.
  • Pain after a hysterectomy.
  • A lung disease called chronic obstructive pulmonary disease (COPD).

Possibly ineffective for...

  • Helping to restart the heart.
  • Improving energy and endurance during athletic activity.
  • Cerebral palsy, when given in the vein of premature infants.
  • Heart attack.

Insufficient evidence to rate effectiveness for...

  • Attention deficit-hyperactivity disorder (ADHD). Children with ADHD seem to have lower magnesium levels. Limited research suggests that magnesium might help ADHD in children with low magnesium levels.
  • Anxiety. There is some evidence that magnesium, hawthorn, and California poppy (Sympathyl) might be effective in treating mild to moderate anxiety disorder. But this product is not available in the US.
  • Restless leg syndrome. Limited research suggests that taking magnesium might decrease the amount of movement and increase the amount of sleep in patients with restless leg syndrome. However, the role of magnesium, if any, in restless leg syndrome is uncertain since some people with the condition have high levels of magnesium in their blood, while other people with the condition have low magnesium levels.
  • High blood pressure (hypertension). Some evidence suggests that taking magnesium reduces diastolic blood pressure (the bottom number in a blood pressure reading) by about 2.2 mmHg in patients with mild to moderate high blood pressure. This is a small reduction. Magnesium does not seem to lower systolic blood pressure (the top number in a blood pressure reading) much. Some researchers question these results because they think the studies were poorly designed.
  • Pregnancy-related leg cramps. Research on the use of magnesium for treating leg cramps caused by pregnancy has been inconsistent. One study shows that magnesium might reduce the frequency of leg cramps. However, another study shows no benefit.
  • Hayfever.
  • Lyme disease.
  • Multiple sclerosis (MS).
  • Premature labor.
  • Other conditions.
More evidence is needed to rate magnesium for these uses.

How does it work?

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Magnesium is required for the proper growth and maintenance of bones. Magnesium is also required for the proper function of nerves, muscles, and many other parts of the body. In the stomach, magnesium helps neutralize stomach acid and moves stools through the intestine.

Are there safety concerns?

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Magnesium is LIKELY SAFE for most people when taken by mouth or when the prescription-only, injectable product is used correctly. In some people, magnesium might cause stomach upset, nausea, vomiting, diarrhea, and other side effects.

Doses less than 350 mg per day are safe for most adults. When taken in very large amounts, magnesium is POSSIBLY UNSAFE. Large doses might cause too much magnesium to build up in the body, causing serious side effects including an irregular heartbeat, low blood pressure, confusion, slowed breathing, coma, and death.

Special precautions & warnings:

Pregnancy and breast-feeding: Magnesium is LIKELY SAFE for pregnant or breast-feeding women when taken by mouth in the amounts recommended. These amounts depend on the age of the woman. Check with your healthcare provider to find out what amounts are right for you.

Heart block: High doses of magnesium (typically delivered by IV) should not be given to people with heart block.

Kidney problems, such as kidney failure: Kidneys that don’t work well have trouble clearing magnesium from the body. Taking extra magnesium can cause magnesium to build up to dangerous levels. Don’t take magnesium if you have kidney problems.

Are there interactions with medications?

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Moderate

Be cautious with this combination.

Antibiotics (Aminoglycoside antibiotics)
Some antibiotics can affect the muscles. These antibiotics are called aminoglycosides. Magnesium can also affect the muscles. Taking these antibiotics and getting a magnesium shot might cause muscle problems.

Some aminoglycoside antibiotics include amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), streptomycin, tobramycin (Nebcin), and others.

Antibiotics (Quinolone antibiotics)
Magnesium might decrease how much antibiotic the body absorbs. Taking magnesium along with some antibiotics might decrease the effectiveness of some antibiotics. To avoid this interaction, take these antibiotics at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Some of these antibiotics that might interact with magnesium include ciprofloxacin (Cipro), enoxacin (Penetrex), norfloxacin (Chibroxin, Noroxin), sparfloxacin (Zagam), trovafloxacin (Trovan), and grepafloxacin (Raxar).

Antibiotics (Tetracycline antibiotics)
Magnesium can attach to tetracyclines in the stomach. This decreases the amount of tetracyclines that the body can absorb. Taking magnesium along with tetracyclines might decrease the effectiveness of tetracyclines. To avoid this interaction, take calcium 2 hours before, or 4 hours after, taking tetracyclines.

Some tetracyclines include demeclocycline (Declomycin), minocycline (Minocin), and tetracycline (Achromycin).

Bisphosphonates
Magnesium can decrease how much bisphosphate the body absorbs. Taking magnesium along with bisphosphates can decrease the effectiveness of bisphosphate. To avoid this interaction, take bisphosphonate at least two hours before magnesium or later in the day.

Some bisphosphonates include alendronate (Fosamax), etidronate (Didronel), risedronate (Actonel), tiludronate (Skelid), and others.

Medications for high blood pressure (Calcium channel blockers)
Magnesium might lower blood pressure. Taking magnesium with medication for high blood pressure might cause your blood pressure to go too low.

Some medications for high blood pressure include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others.

Muscle relaxants
Magnesium seems to help relax muscles. Taking magnesium along with muscle relaxants can increase the risk of side effects of muscle relaxants.

Some muscle relaxants include carisoprodol (Soma), pipecuronium (Arduan), orphenadrine (Banflex, Disipal), cyclobenzaprine, gallamine (Flaxedil), atracurium (Tracrium), pancuronium (Pavulon), succinylcholine (Anectine), and others.

Water pills (Potassium-sparing diuretics)
Some "water pills" can increase magnesium levels in the body. Taking some "water pills" along with magnesium might cause too much magnesium to be in the body.

Some "water pills" that increase magnesium in the body include amiloride (Midamor), spironolactone (Aldactone), and triamterene (Dyrenium).

Are there interactions with herbs and supplements?

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Boron
Magnesium in the blood is processed by the kidneys and excreted into the urine. It then leaves the body. In women, boron supplements can slow this process down and raise magnesium levels in the blood. In young women, age 18 to 25 years, the effect appears to be greater in less active women than in athletic women. In postmenopausal women, the effect is more marked in women with low dietary magnesium intake. It is not known how important these effects are or whether they occur in men.

Calcium
Calcium supplements can decrease the absorption of dietary magnesium, but only at very high doses (2600 mg per day). However, in people with adequate magnesium stores, calcium doesn't have any clinically significant effect on long-term magnesium balance. People at high risk for magnesium deficiency should take calcium supplements at bedtime, instead of with meals, to avoid interfering with dietary magnesium absorption. Magnesium does not seem to affect calcium absorption.

Malic acid
Malic acid is used with magnesium hydroxide for reducing pain and tenderness associated with fibromyalgia. Why this works and whether there are any interactions between malic acid and magnesium hydroxide isn't known.

Vitamin D
Various forms of vitamin D increase magnesium absorption; especially when taken in high doses. This effect has been used to treat low magnesium in people with conditions that make it difficult for them to absorb magnesium.

Zinc
High doses of zinc (142 mg/day) appear to decrease magnesium absorption and magnesium balance in healthy adult men. Also, moderately high dietary zinc intake (53 mg per day) seems to increase magnesium loss in postmenopausal women. This might harm bone health. More research is needed to find out how important this interaction is.

Are there interactions with foods?

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There are no known interactions with foods.

What dose is used?

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The following doses have been studied in scientific research:

BY MOUTH:
  • For reducing the frequency and severity of migraine headaches:
    • magnesium citrate 1830 mg in 3 divided doses for up to 3 months.
    • trimagnesium dicitrate 600 mg (24 mmol) daily for up to 3 months.
  • For reducing the frequency and severity of migraine headaches in children: magnesium oxide 9 mg per kg in 3 divided doses for up to 16 weeks.
  • For treatment of low magnesium levels in patients with type 2 diabetes: 50 mL magnesium chloride solution (containing 50 grams magnesium chloride per 1000 mL of solution) daily for 16 weeks.
  • For weak bones (osteoporosis): 150-750 mg/day has been used as a single agent or in combination with calcium or other supplements.
  • For premenstrual syndrome (PMS): 200-360 mg/day.
The daily Recommended Dietary Allowances (RDA) for elemental magnesium are: Age 1-3 years, 80 mg; 4-8 years, 130 mg; 9-13 years, 240 mg; 14-18 years, 410 mg (boys) and 360 mg (girls); 19-30 years, 400 mg (men) and 310 mg (women); 31 years and older, 420 mg (men) and 320 mg (women). For pregnant women age 14-18 years, the RDA is 400 mg; 19-30 years, 350 mg; 31-50 years, 360 mg. For lactating women age 14-18 years, the RDA is 360 mg; 19-30 years, 310 mg; 31-50 years, 320 mg. For infants less than one year of age, adequate intake (AI) levels are 30 mg from birth to 6 months and 75 mg from 7 to 12 months. The daily upper intake level (UL) for magnesium is 65 mg for children age 1-3 years, 110 mg for 4-8 years, and 350 mg for anyone over 8 years old, including pregnant and breast-feeding women.

Other names

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Aspartate de Magnésium, Atomic Number 12, Carbonate de Magnésium, Chelated Magnesium, Chlorure de Magnésium, Citrate de Magnésium, Dimagnesium Malate, Epsom Salts, Gluconate de Magnésium, Glycérophosphate de Magnésium, Glycinate de Magnésium, Hydroxyde de Magnésium, Lactate de Magnésium, Lait de Magnésium, Magnesia, Magnesia Carbonica, Magnesia Muriatica, Magnesia Sulfate, Magnesia Sulfurica, Magnesio, Magnésium, Magnesium Ascorbate, Magnesium Aspartate, Magnesium Carbonate, Magnésium Chelaté, Magnesium Chloride, Magnesium Citrate, Magnesium Disuccinate Hydrate, Magnesium Gluconate, Magnesium Glycerophosphate, Magnesium Glycinate, Magnesium Hydroxide, Magnesium Lactate, Magnesium Malate, Magnesium Murakab, Magnesium Orotate, Magnesium Oxide, Magnesium Phosphate, Magnesium Phosphoricum, Magnesium Sulfate, Magnesium Taurate, Magnesium Taurinate, Magnesium Trisilicate, Malate de Magnésium, Milk of Magnesia, Mg, Numéro Atomique 12, Orotate de Magnésium, Oxyde de Magnésium, Phosphate de Magnésium, Sels d’Epsom, Sulfate de Magnésium, Trisilicate de Magnésium.

Methodology

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To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.methodology (http://www.nlm.nih.gov/medlineplus/druginfo/natural/methodology.html).

References

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To see all references for the Magnesium page, please go to http://www.nlm.nih.gov/medlineplus/druginfo/natural/998.html.

  1. Fernández-Fernández FJ, Sesma P, Caínzos-Romero T, Ferreira-González L. Intermittent use of pantoprazole and famotidine in severe hypomagnesaemia due to omeprazole. Neth J Med 2010;68:329-30.
  2. Faulhaber GA, Furlanetto TW. Could magnesium depletion play a role on fracture risk in PPI users? Arch Intern Med 2010;170:1776.
  3. Cundy T, Mackay J. Proton pump inhibitors and severe hypomagnesaemia. Curr Opin Gastroenterol 2011;27:180-5.
  4. Regolisti G, Cabassi A, Parenti E, et al. Severe hypomagnesemia during long-term treatment with a proton pump inhibitor. Am J Kidney Dis 2010;56:168-74.
  5. Hoorn EJ, van der Hoek J, de Man RA, et al. A case series of proton pump inhibitor-induced hypomagnesemia. Am J Kidney Dis 2010;56:112-6.
  6. Broeren MA, Geerdink EA, Vader HL, van den Wall Bake AW. Hypomagnesemia induced by several proton-pump inhibitors. Ann Intern Med 2009;151:755-6.
  7. François M, Lévy-Bohbot N, Caron J, Durlach V. [Chronic use of proton-pump inhibitors associated with giardiasis: A rare cause of hypomagnesemic hypoparathyroidism?]. Ann Endocrinol (Paris) 2008;69:446-8.
  8. Epstein M, McGrath S, Law F. Proton-pump inhibitors and hypomagnesemic hypoparathyroidism. N Engl J Med 2006;355:1834-6.
  9. Doornebal J, Bijlsma R, Brouwer RM. [An unknown but potentially serious side effect of proton pump inhibitors: hypomagnesaemia]. Ned Tijdschr Geneeskd 2009;153:A711.
  10. Cundy T, Dissanayake A. Severe hypomagnesaemia in long-term users of proton-pump inhibitors. Clin Endocrinol (Oxf) 2008;69:338-41.
  1. Kuipers MT, Thang HD, Arntzenius AB. Hypomagnesaemia due to use of proton pump inhibitors--a review. Neth J Med 2009;67:169-72.
  2. Mackay JD, Bladon PT. Hypomagnesaemia due to proton-pump inhibitor therapy: a clinical case series. QJM 2010;103:387-95.
  3. Safety Alert. Proton Pump Inhibitor drugs (PPIs): Drug Safety Communication - Low Magnesium Levels Can Be Associated With Long-Term Use. U.S. Food and Drug Administration, March 2, 2011. Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/ SafetyAlertsforHumanMedicalProducts/ucm245275.htm
  4. Nygaard IH, Valbø A, Pethick SV, Bøhmer T. Does oral magnesium substitution relieve pregnancy-induced leg cramps? Eur J Obstet Gynecol Reprod Biol 2008;141:23-6.
  5. Larsson SC, Wolk A. Magnesium intake and risk of type-2 diabetes: a meta-analysis. J Intern Med 2007:262:208-14.
  6. Vectibix (panitumumab) product information. Amgen Inc., Thousand Oaks, CA. June 2007.
  7. Erbitux (cetuximab) product information. Bristol-Myers Squibb Company, Princeton, NJ. May 2007.
  8. Fakih M. Anti-EGFR monoclonal antibody-induced hypomagnesaemia. Lancet Oncol 2007;8:366-7.
  9. Dickinson HO, Nicolson DJ, Campbell F, et al. Magnesium supplementation for the management of essential hypertension in adults. Cochrane Database Syst Rev 2006;3:CD004640.
  10. Young GL, Jewell D. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev 2002;:CD000121.
  11. He K, Liu K, Daviglus ML, et al. Magnesium intake and incidence of metabolic syndrome among young adults. Circulation 2006;113:1675-82.
  12. Firoz M, Graber M. Bioavailability of US commercial magnesium preparations. Magnes Res 2001;14:257-62.
  13. McCarty MF. Magnesium may mediate the favorable impact of whole grains on insulin sensitivity by acting as a mild calcium antagonist. Med Hypotheses 2005;64:619-27.
  14. De Leeuw I, Engelen W, De Block C, Van Gaal L. Long term magnesium supplementation influences favourably the natural evolution of neuropathy in Mg-depleted type 1 diabetic patients (T1dm). Magnes Res 2004;17:109-14.
  15. Gullestad L, Jacobsen T, Dolva LO. Effect of magnesium treatment on glycemic control and metabolic parameters in NIDDM patients. Diabetes Care 1994;17:460-1
  16. Eibl NL, Kopp HP, Nowak HR, et al. Hypomagnesemia in type II diabetes: effect of a 3-month replacement therapy. Diabetes Care 1995;18:188-92.
  17. Paolisso G, Scheen A, Cozzolino D, et al. Changes in glucose turnover parameters and improvement of glucose oxidation after 4-week magnesium administration in elderly noninsulin-dependent (type II) diabetic patients. J Clin Endocrinol Metab 1994;78:1510-4.
  18. Guerrero-Romero F, Tamez-Perez HE, Gonzalez-Gonzalez G, et al. Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. A double-blind placebo-controlled randomized trial. Diabetes Metab 2004;30:253-8.
  19. Paolisso G, Sgambato S, Gambardella A, et al. Daily magnesium supplements improve glucose handling in elderly subjects. Am J Clin Nutr 1992;55:1161-7.
  20. Walti MK, Zimmermann MB, Walczyk T, et al. Measurement of magnesium absorption and retention in type 2 diabetic patients with the use of stable isotopes. Am J Clin Nutr 2003;78:448-53.
  21. Guerrero-Romero F, Rodriguez-Moran M. Relationship between serum magnesium levels and C-reactive protein concentration, in non-diabetic, non-hypertensive obese subjects. Int J Obes Relat Metab Disord 2002;26:469-74.
  22. Guerrero-Romero F, Rodriguez-Moran M. Low serum magnesium levels and metabolic syndrome. Acta Diabetol 2002;39:209-13.
  23. King DE, Mainous AG 3rd, Geesey ME, Woolson RF. Dietary magnesium and C-reactive protein levels. J Am Coll Nutr 2005;24:166-71.
  24. Huerta MG, Roemmich JN, Kington ML, et al. Magnesium deficiency is associated with insulin resistance in obese children. Diabetes Care 2005;28:1175-81.
  25. Lopez-Ridaura R, Willett WC, Rimm EB, et al. Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care 2004;27:134-40.
  26. Fung TT, Manson JE, Solomon CG, et al. The association between magnesium intake and fasting insulin concentration in healthy middle-aged women. J Am Coll Nutr 2003;22:533-8.
  27. Guerrero-Romero F, Rodriguez-Moran M. Complementary therapies for diabetes: the case for chromium, magnesium, and antioxidants. Arch Med Res 2005;36:250-7.
  28. Barbagallo M, Dominguez LJ, Galioto A, et al. Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Mol Aspects Med 2003;24:39-52.
  29. Sabra R, Branch RA. Amphotericin B nephrotoxicity. Drug Saf 1990;5:94-108.
  30. Dunn CJ, Goa KL. Risedronate: a review of its pharmacological properties and clinical use in resorptive bone disease. Drugs 2001;61:685-712.
  31. L'Hommedieu CS, Nicholas D, Armes DA, et al. Potentiation of magnesium sulfate--induced neuromuscular weakness by gentamicin, tobramycin, and amikacin. J Pediatr 1983;102:629-31.
  32. Muir KW, Lees KR, Ford I, et al. Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial. Lancet 2004;363:439-45.
  33. Ziegelstein RC, Hilbe JM, French WJ, et al. Magnesium use in the treatment of acute myocardial infarction in the United States (observations from the Second National Registry of Myocardial Infarction). Am J Cardiol 2001;87:7-10.
  34. Nameki M, Ishibashi I, Miyazaki Y, et al. Comparison between nicorandil and magnesium as an adjunct cardioprotective agent to percutaneous coronary intervention in acute anterior myocardial infarction. Circ J 2004;68:192-7.
  35. Santoro GM, Antoniucci D, Bolognese L, et al. A randomized study of intravenous magnesium in acute myocardial infarction treated with direct coronary angioplasty. Am Heart J 2000;140:891-7.
  36. Magnesium in Coronaries (MAGIC) Trial Investigators. Early administration of intravenous magnesium to high-risk patients with acute myocardial infarction in the Magnesium in Coronaries (MAGIC) Trial: a randomised controlled trial. Lancet 2002;360:1189-96.
  37. Davey MJ, Teubner D. A randomized controlled trial of magnesium sulfate, in addition to usual care, for rate control in atrial fibrillation. Ann Emerg Med 2005;45:347-53.
  38. Iseri LT, Fairshter RD, Hardemann JL, Brodsky MA. Magnesium and potassium therapy in multifocal atrial tachycardia. Am Heart J 1985;110:789-94.
  39. McCord JK, Borzak S, Davis T, Gheorghiade M. Usefulness of intravenous magnesium for multifocal atrial tachycardia in patients with chronic obstructive pulmonary disease. Am J Cardiol 1998;81:91-3.
  40. Christiansen EH, Frost L, Andreasen F, et al. Dose-related cardiac electrophysiological effects of intravenous magnesium. A double-blind placebo-controlled dose-response study in patients with paroxysmal supraventricular tachycardia. Europace 2000;2:320-6.
  41. Crowther CA, Hiller JE, Doyle LW, et al. Effect of magnesium sulfate given for neuroprotection before preterm birth: a randomized controlled trial. JAMA 2003;290:2669-76.
  42. Crowther CA, Hiller JE, Doyle LW. Magnesium sulphate for preventing preterm birth in threatened preterm labour. Cochrane Database Syst Rev 2002;4:CD001060.
  43. Witlin AG, Sibai BM. Magnesium sulfate therapy in preeclampsia and eclampsia. Obstet Gynecol 1998;92:883-9.
  44. Altman D, Carroli G, Duley L, et al. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Lancet 2002;359:1877-90.
  45. Mittendorf R, Dambrosia J, Pryde PG, et al. Association between the use of antenatal magnesium sulfate in preterm labor and adverse health outcomes in infants. Am J Obstet Gynecol 2002;186:1111-8.
  46. Jeyabalan A, Caritis SN. Pharmacologic inhibition of preterm labor. Clin Obstet Gynecol 2002;45:99-113.
  47. Fine KD, Santa Ana CA, Porter JL, et al. Intestinal absorption of magnesium from food and supplements. J Clin Invest 1991;88:396-402.
  48. Sompolinsky D, Samra Z. Influence of magnesium and manganese on some biological and physical properties of tetracycline. J Bacteriol 1972;110:468-76.
  49. Johnson S. The multifaceted and widespread pathology of magnesium deficiency. Med Hypotheses 2001;56:163-70.
  50. Nechifor M, Vaideanu C, Palamaru I, et al. The influence of some antipsychotics on erythrocyte magnesium and plasma magnesium, calcium, copper and zinc in patients with paranoid schizophrenia. J Am Coll Nutr 2004;23:549S-51S.
  51. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders. Curr Med Res Opin 2004;20:63-71.
  52. Yokota K, Kato M, Lister F, et al. Clinical efficacy of magnesium supplementation in patients with type 2 diabetes. J Am Coll Nutr 2004;23:506S-509S.
  53. Ford ES, Mokdad AH. Dietary magnesium intake in a national sample of US adults. J Nutr 2003;133:2879-82.
  54. Cohen N, Almoznino-Sarafian D, Zaidenstein R, et al. Serum magnesium aberrations in furosemide (frusemide) treated patients with congestive heart failure: pathophysiological correlates and prognostic evaluation. Heart 2003;89:411-6.
  55. Vetter T, Lohse MJ. Magnesium and the parathyroid. Curr Opin Nephrol Hypertens 2002;11:403-10.
  56. FDA. Dietary Supplement Enforcement Report July 2003. Available at: http://www.fda.gov/oc/whitepapers/chbn_summary.html
  57. Rude RK. Magnesium deficiency: a cause of heterogeneous disease in humans. J Bone Miner Res 1998;13:749-58.
  58. Abraham GE, Grewal H. A total dietary program emphasizing magnesium instead of calcium. Effect on the mineral density of calcaneous bone in postmenopausal women on hormonal therapy. J Reprod Med 1990;35:503-7.
  59. Ilich JZ, Kerstetter JE. Nutrition in bone health revisited: a story beyond calcium. J Am Coll Nutr 2000;19:715-37.
  60. Tranquilli AL, Lucino E, Garzetti GG, Romanini C. Calcium, phosphorus and magnesium intakes correlate with bone mineral content in postmenopausal women. Gynecol Endocrinol 1994;8:55-8.
  61. New SA, Bolton-Smith C, Grubb DA, Reid DM. Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr 1997;65:1831-9.
  62. Houtkooper LB, Ritenbaugh C, Aickin M, et al. Nutrients, body composition and exercise are related to change in bone mineral density in premenopausal women. J Nutr 1995;125:1229-37.
  63. Tucker KL, Hannan MT, Chen H, et al. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 1999;69:727-36.
  64. Rude RK, Gruber HE, Norton HJ, et al. Bone loss induced by dietary magnesium reduction to 10% of the nutrient requirement in rats is associated with increased release of substance P and tumor necrosis factor-alpha. J Nutr 2004;134:79-85.
  65. Stendig-Lindberg G, Koeller W, Bauer A, Rob PM. Experimentally induced prolonged magnesium deficiency causes osteoporosis in the rat. Eur J Intern Med 2004;15:97-107.
  66. Nielsen FH, Milne DB. A moderately high intake compared to a low intake of zinc depresses magnesium balance and alters indices of bone turnover in postmenopausal women. Eur J Clin Nutr 2004;58:703-10.
  67. Maizels M, Blumenfeld A, Burchette R. A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Headache 2004;44:885-90.
  68. Trauninger A, Pfund Z, Koszegi T, Czopf J. Oral magnesium load test in patients with migraine. Headache 2002;42:114-9.
  69. Song Y, Manson JE, Buring JE, Liu S. Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women. Diabetes Care 2004;27:59-65.
  70. Sojka J, Wastney M, Abrams S, et al. Magnesium kinetics in adolescent girls determined using stable isotopes: effects of high and low calcium intake. Am J Physiol 1997;273:R710-5.
  71. Rodriguez-Moran M, Guerrero-Romero F. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: A randomized double-blind controlled trial. Diabetes Care 2003;26:1147-52.
  72. Wang F, Van Den Eeden SK, Ackerson LM, et al. Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial. Headache 2003;43:601-10.
  73. Pfaffenrath V, Wessely P, Meyer C, et al. Magnesium in the prophylaxis of migraine--a double-blind placebo-controlled study. Cephalalgia 1996;16:436-40.
  74. Kozielec T, Starobrat-Hermelin B. Assessment of magnesium levels in children with attention deficit hyperactivity disorder (ADHD). Magnes Res 1997;10:143-8.
  75. Rolla G, Bucca C. Magnesium, beta-agonists, and asthma. Lancet 1988;1:989.
  76. Stanton MF, Lowenstein FW. Serum magnesium in women during pregnancy, while taking contraceptives, and after menopause. J Am Coll Nutr 1987;6:313-9.
  77. Seelig MS. Interrelationship of magnesium and estrogen in cardiovascular and bone disorders, eclampsia, migraine, and premenstrual syndrome. J Am Coll Nutr 1993;12:442-58.
  78. Muneyyirci-Delale O, Nacharaju VL, Dalloul M, et al. Serum ionized magnesium and calcium in women after menopause: inverse relation of estrogen with ionized magnesium. Fertil Steril 1999;71:869-72.
  79. Krejs GJ, Nicar MJ, Zerwekh JE, et al. Effect of 1,25-dihydroxyvitamin D3 on calcium and magnesium absorption in the healthy human jejunum and ileum. Am J Med 1983;75:973-6.
  80. Fukumoto S, Matsumoto T, Tanaka Y, et al. Renal magnesium wasting in a patient with short bowel syndrome with magnesium deficiency: effect of 1-alpha-hydroxyvitamin D3 treatment. J Clin Endocrinol Metab 1987;65:1301-4.
  81. Charles P, Mosekilde L, Sondergard K, Jensen FT. Treatment with high-dose oral vitamin D2 in patients with jejunoileal bypass for morbid obesity. Effects on calcium and magnesium metabolism, vitamin D metabolites and faecal lag time. Scand J Gastroenterol 1984;19:1031-8.
  82. Hardwick LL, Jones MR, Brautbar N, Lee DB. Magnesium absorption: mechanisms and the influence of vitamin D, calcium and phosphate. J Nutr 1991;121:13-23.
  83. Allen RD, Hunnisett AG, Morris PJ. Cyclosporine and magnesium. Lancet 1985;1:1283-4.
  84. Thompson CB, Sullivan KM, June CH, Thomas ED. Association between cyclosporine neurotoxicity and hypomagnesemia. Lancet 1984;2:1116-20.
  85. Gottlieb SS. Importance of magnesium in congestive heart failure. Am J Cardiol 1989;63:39G-42G.
  86. Cantilena LR, Klaassen CD. The effect of chelating agents on the excretion of endogenous metals. Toxicol Appl Pharmacol 1982;63:344-50.
  87. Kleeman CR, Levi J, Better O. Kidney and adrenocortical hormones. Nephron 1975;15:261-78.
  88. Quamme GA. Renal handling of magnesium: drug and hormone interactions. Magnesium 1986;5:248-72.
  89. Runeberg L, Miettinen TA, Nikkila EA. Effect of cholestyramine on mineral excretion in man. Acta Med Scand 1972;192:71-6.
  90. Martin M, Diaz-Rubio E, Casado A, et al. Intravenous and oral magnesium supplementation in the prophylaxis of cisplatin-induced hypomagnesemia. Results of a controlled trial. Am J Clin Oncol 1992;15:348-51
  91. Hirschel-Scholz S, Paunier L, Bonjour JP. Interference of WR-2721 with magnesium metabolism: mechanism of action. Miner Electrolyte Metab 1988;14:114-20.
  92. Spencer H, Norris C, Williams D. Inhibitory effects of zinc on magnesium balance and magnesium absorption in man. J Am Coll Nutr 1994;13:479-84.
  93. Nielsen FH, Hunt CD, Mullen LM, Hunt JR. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J 1987;1:394-7.
  94. Heidenreich O. Mode of action of conventional and potassium-sparing diuretics--aspects with relevance to Mg-sparing effects. Magnesium 1984;3:248-56.
  95. Seelig MS. Increased need for magnesium with the use of combined oestrogen and calcium for osteoporosis treatment. Magnes Res 1990;3:197-215.
  96. Niederstadt C, Steinhoff J, Erbsloh-Moller B, et al. Effect of FK506 on magnesium homeostasis after renal transplantation. Transplant Proc 1997;29:3161-2.
  97. Gradon JD, Fricchione L, Sepkowitz D. Severe hypomagnesemia associated with pentamidine therapy. Rev Infect Dis 1991;13:511-2.
  98. Burnett RJ, Reents SB. Severe hypomagnesemia induced by pentamidine. DICP Ann Pharmacother 1990;24:239-40.
  99. Palestine AG, Polis MA, De Smet MD, et al. A randomized, controlled trial of foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS. Ann Int Med 1991;115:665-73.
  100. Ehrenpreis ED, Wieland JM, Cabral J, et al. Symptomatic hypocalcemia, hypomagnesemia, and hyperphosphatemia sceondary to Fleet's Phospho-Soda colonoscopy preparation in a patient with a jejunoileal bypass. Dig Dis Sci 1997;42:858-60.
  101. Schwarz RE, Zagala-Nevarez K. Significant hypomagnesemia after celiotomy: implications of preoperative bowel cleansing with sodium phosphate purgative. Surgery 2002;131:236.
  102. Hollifield JW. Magnesium depletion, diuretics, and arrhythmias. Am J Med 1987;82:30-7.
  103. Ryan MP. Diuretics and potassium/magnesium depletion: directions for treatment. Am J Med 1987;82:38-47.
  104. Watkins DW, Khalafi R, Cassidy MM, Vahouny GV. Alterations in calcium, magnesium, iron, and zinc metabolism by dietary cholestyramine. Dig Dis Sci 1985;30:477-82.
  105. Nielsen FH. Biochemical and physiologic consequences of boron deprivation in humans. Environ Health Perspect 1994;102:59-63.
  106. Whyte KF, Addis GJ, Whitesmith R, Reid JL. Adrenergic control of plasma magnesium in man. Clin Sci 1987;72:135-8.
  107. Selby PL, Peacock M, Bambach CP. Hypomagnesemia after small bowel resection: treatment with 1-alpha-hydroxylated vitamin D metabolites. Br J Surg 1984;71:334-7.
  108. Rickers H, Deding A, Christiansen C, Rodbro P. Mineral loss in cortical and trabecular bone during high-dose prednisone treatment. Calcif Tissue Int 1984;36:269-73.
  109. Lund B, Storm TL, Lund B, et al. Bone mineral loss, bone histomorphometry and vitamin D metabolism in patients with rheumatoid arthritis on long-term glucocorticoid treatment. Clin Rheumatol 1985;4:143-9.
  110. Rolla G, Bucca C, Bugiani M, et al. Hypomagnesemia in chronic obstructive lung disease: effect of therapy. Magnes Trace Elem 1990;9:132-6.
  111. Pere AK, Lindgren L, Tuomainen P, et al. Dietary potassium and magnesium supplementation in cyclosporine-induced hypertension and nephrotoxicity. Kidney Int 2000;58:2462-72.
  112. Rossier P, van Erven S, Wade DT. The effect of magnesium oral therapy on spasticity in a patient with multiple sclerosis. Eur J Neurol 2000;7:741-4.
  113. Demirkaya S, Dora B, Topcuoglu MA, et al. A comparative study of magnesium, flunarizine and amitriptyline in the prophylaxis of migraine. J Headache Pain 2000;1:179-86.
  114. Ceremuzynski L, Gebalska J, Wolk R, Makowska E. Hypomagnesemia in heart failure with ventricular arrhythmias. Beneficial effects of magnesium supplementation. J Intern Med 2000;247:78-86.
  115. Ciarallo L, Brousseau D, Reinert S. Higher-dose intravenous magnesium therapy for children with moderate to severe acute asthma. Arch Pediatr Adolesc Med 2000;154:979-83.
  116. Schenk P, Vonbank K, Schnack B, et al. Intravenous magnesium sulfate for bronchial hyperreactivity: a randomized, controlled, double-blind study. Clin Pharmacol Ther 2001;69:365-71.
  117. Belfort MA, Anthony J, Saade GR, Allen JC Jr. A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia. N Engl J Med 2003;348:304-11.
  118. Popoviciu L, Asgian B, Delast-Popoviciu D, et al. Clinical, EEG, electromyographic and polysomnographic studies in restless legs syndrome caused by magnesium deficiency (abstract). Rom J Neurol Psychiatry 1993;31:55-61.
  119. Hornyak M, Voderholzer U, Hohagen F, et al. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Sleep 1998;21:501-5.
  120. Jee SH, Miller ER 3rd, Guallar E, et al. The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials. Am J Hypertens 2002;15:691-6.
  121. Rahman MA, Ing TS. Cyclosporine and magnesium metabolism. J Lab Clin Med 1989;114:213-4.
  122. Stendig-Lindberg G, Tepper R, Leichter I. Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnes Res 1993;6:155-63.
  123. Muir KW, Lees KR. Dose optimization of intravenous magnesium sulfate after acute stroke. Stroke 1998;29:918-23.
  124. Ascherio A, Rimm EB, Hernan MA, et al. Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men. Circulation 1998;98:1198-204.
  125. Suter PM. The effects of potassium, magnesium, calcium, and fiber on risk of stroke. Nutr Rev 1999;57:84-8.
  126. Muir KW, Lees KR. A randomized, double-blind, placebo-controlled pilot trial of intravenous magnesium sulfate in acute stroke. Stroke 1995;26:1183-8.
  127. Bhargava B, Chandra S, Agarwal VV, et al. Adjunctive magnesium infusion therapy in acute myocardial infarction. Int J Cardiol 1995;52:95-9.
  128. Altura BT, Memon ZI, Zhang A, et al. Low levels of serum ionized magnesium are found in patients early after stroke which result in rapid elevation in cytosolic free calcium and spasm in cerebral vascular muscle cells. Neurosci Lett 1997;230:37-40.
  129. Lote CJ, Thewles A, Wood JA, Zafar T. The hypomagnesaemic action of FK506: urinary excretion of magnesium and calcium and the role of parathyroid hormone. Clin Sci 2000;99:285-92.
  130. Rahman ARA, McDevitt DG, Struthers AD, Lipworth BJ. The effects of enalapril and spironolactone on terbutaline-induced hypokalemia. Chest 1992;102:91-5.
  131. Kozeny GA, Nicolas JD, Creekmore S, et al. Effects of interleukin-2 immunotherapy on renal function. J Clin Oncol 1988;6:1170-6.
  132. Shah GM, Alvarado P, Kirschenbaum MA. Symptomatic hypocalcemia and hypomagnesemia with renal magnesium wasting associated with pentamidine therapy in a patient with AIDS. Am J Med 1990;89:380-2.
  133. Gearhart MO, Sorg TB. Foscarnet-induced severe hypomagnesemia and other electrolyte disturbances. Ann Pharmacother 1993;27:285-9.
  134. Sabatier M, Arnaud MJ, Kastenmayer P, et al. Meal effect on magnesium bioavailability from mineral water in healthy women. Am J Clin Nutr 2002;75:65-71.
  135. Sacks FM, Willett WC, Smith A, et al. Effect on blood pressure of potassium, calcium, and magnesium in women with low habitual intake. Hypertension 1998;31:131-8.
  136. Ettinger B, Citron JT, Livermore B, Dolman LI. Chlorthanlidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. J Urol 1988;139:679-84.
  137. Frankel BL, Patten BM, Gillin JC. Restless leg syndrome. Sleep-electroencephalographic and neurologic findings. JAMA 1974;230:1302-3.
  138. Birrer RB, Shallash AJ, Totten V. Hypermagnesemia-induced fatality following epsom salt gargles. J Emerg Med 2002;22:185-8.
  139. Cohen JS. High-dose oral magnesium treatment of chronic, intractable erythromelalgia. Ann Pharmacother 2002;36:255-60.
  140. Grether JK, Hoogstrate J, Walsh-Greene E, Nelson KB. Magnesium sulfate for tocolysis and risk of spastic cerebral palsy in premature children born to women without preeclampsia. Am J Obstet Gynecol 2000;183:717-25.
  141. Kosch M, Hausberg M, Westermann G, et al. Alterations in calcium and magnesium content of red cell membranes in patients with primary hypertension. Am J Hypertens 2001;14:254-8.
  142. Teragawa H, Kato M, Yamagata T, et al. The preventive effect of magnesium on coronary spasm in patients with vasospastic angina. Chest 2000;118:1690-5.
  143. Seelig M, Altura BM. How best to determine magnesium requirement: need to consider cardiotherapeutic drugs that affect its retention. J Am Coll Nutr 1997;16:4-6.
  144. Costello RB, Moser-Veillon PB, DiBianco R. Magnesium supplementation in patients with congestive heart failure. J Am Coll Nutr 1997;16:22-31.
  145. Douban S, Brodsky MA, Whang DD, Whang R. Significance of magnesium in congestive heart failure. Am Heart J 1996;132:664-71.
  146. Deulofeu R, Gascon J, Gimenez N, Corachan M. Magnesium and chronic fatigue syndrome. Lancet 1991;338:641.
  147. Gantz NM. Magnesium and chronic fatigue. Lancet 1991;338:66.
  148. Young IS, Trimble ER. Magnesium and chronic fatigue syndrome. Lancet 1991;337;1094-5.
  149. Clague JE, Edwards RH, Jackson MJ. Intravenous magnesium loading in chronic fatigue syndrome. Lancet 1992;340:124-5.
  150. Hinds G, Bell NP, McMaster D, McCluskey DR. Normal red cell magnesium concentrations and magnesium loading tests in patients with chronic fatigue syndrome. Ann Clin Biochem 1994;31:459-61.
  151. Cox IM, Campbell MJ, Dowson D. Red blood cell magnesium and chronic fatigue syndrome. Lancet 1991;337:757-60.
  152. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press, 1999. Available at: http://books.nap.edu/books/0309063507/html/index.html.
  153. Tramer MR, Schneider J, Marti RA, Rifat K. Role of magnesium sulfate in postoperative analgesia. Anesthesiology 1996;84:340-7.
  154. Bendich A. The potential for dietary supplements to reduce premenstrual syndrome (PMS) symptoms. J Am Coll Nutrition 2000;19:3-12.
  155. Crosby V, Wilcock A, Corcoran R. The safety and efficacy of a single dose (500 mg or 1 g) of intravenous magnesium sulfate in neuropathic pain poorly responsive to strong opioid analgesics in patients with cancer. J Pain Symptom Manage 2000;19:35-9.
  156. Meyer KA, Kushi LH, Jacobs DR, et al. Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr 2000;71:921-30.
  157. Swain R, Kaplan-Machlis B. Magnesium for the next millennium. South Med J 1999;92:1040-7.
  158. Anderson PO, Knoben JE. Handbook of Clinical Drug Data. 8th ed. Stamford, CT: Appleton & Lange, 1997.
  159. Geerling BJ, Badart-Smook A, Stockbrugger RW, Brummer RJ. Comprehensive nutritional status in patients with long-standing Crohn disease currently in remission. Am J Clin Nutr 1998;67:919-26.
  160. Galland L. Magnesium and inflammatory bowel disease. Magnesium 1988;7:78-83.
  161. Lipworth BJ, McDevitt DG. Beta-adrenoceptor responses to inhaled salbutamol in normal subjects. Eur J Clin Pharmacol 1989;36:239-45.
  162. Gustafson T, Boman K, Rosenhall L, et al. Skeletal muscle magnesium and potassium in asthmatics treated with oral beta-2-agonists. Eur Resp J 1996;9:237-40.
  163. Bos WJ, Postma DS, van Doormaal JJ. Magnesiuric and calciuric effects of terbutaline in man. Clin Sci 1988;74:595-7.
  164. Khilnani G, Parchani H, Toshniwal G. Hypomagnesemia due to beta 2-agonist use in bronchial asthma. J Assoc Physicians India 1992;40:346.
  165. Bremme K, Eneroth P, Nordstrom L, Nilsson B. Effects of infusion of the beta-adrenoceptor agonist terbutaline on serum magnesium in pregnant women. Magnesium 1986;5:85-94.
  166. Peikert A, Wilimzig C, Kohne-Volland R. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia 1996;16:257-63.
  167. Spencer H, Fuller H, Norris C, Williams D. Effect of magnesium on the intestinal absorption of calcium in man. J Am Coll Nutr 1994;15:485-92.
  168. Schwinger RH, Eromann E. Heart failure and electrolyte disturbances. Methods Find Exp Clin Pharmacol 1992;14:315-25.
  169. Seelig MS. Auto-immune complications of D-penicillamine - A possible result of zinc and magnesium depletion and of pyridoxine inactivation. J Am Coll Nutr 1982;1:207-14.
  170. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  171. Anderson PO, Knoben JE, Troutman WG. Handbook of Clinical Drug Data. 9th ed. Stamford, CT: Appleton & Lange, 1999.
  172. Russell IJ, Michalek JE, Flechas JD, Abraham GE. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol 1995;22:953-8.
  173. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  174. Weller E, Bachert P, Meinck HM, et al. Lack of effect of oral Mg-supplementation on Mg in serum, blood cells, and calf muscle. Med Sci Sports Exerc 1998;30:1584-91.
  175. Maughan RJ, Sadler DJ. The effects of oral administration of salts of aspartic acid on the metabolic response to prolonged exhausting exercise in man. Int J Sports Med 1983;4:119-23.
  176. Hagan RD, Upton SJ, Duncan JJ, et al. Absence of effect of potassium-magnesium aspartate on physiologic responses to prolonged work in aerobically trained men. Int J Sports Med 1982;3:177-81.
  177. Golf SW, Happel O, Graef V, Seim KE. Plasma aldosterone, cortisol and electrolyte concentrations in physical exercise after magnesium supplementation. J Clin Chem Clin Biochem 1984;22:717-21.
  178. Golf SW, Bender S, Gruttner J. On the significance of magnesium in extreme physical stress. Cardiovasc Drugs Ther 1998;12:197-202.
  179. de Haan A, van Doorn JE, Westra HG. Effects of potassium plus magnesium aspartate on muscle metabolism and force development during short intensive static exercise. Int J Sports Med 1985;6:44-9.
  180. Tveskov C, Djurhuus MS, Klitgaard NAH, Egstrup K. Potassium and magnesium distribution, ECG changes, and ventricular ectopic beats during beta-2-adrenergic stimulation with terbutaline in healthy subjects. Chest 1994;106:1654-9.
  181. Johansson G, Backman U, Danielson BG, et al. Biochemical and clinical effects of the prophylactic treatment of renal calcium stones with magnesium hydroxide. J Urol 1980;124:770–4.
  182. Li MK, Blacklock NJ, Garside J. Effects of magnesium on calcium oxalate crystallization. J Urol 1985;133:23.
  183. Moghissi KS. Risks and benefits of nutritional supplements during pregnancy. Obstet Gynecol 1981;58:68S-78S.
  184. McGuire JK, Kulkarni MS, Baden HP. Fatal hypermagnesemia in a child treated with megavitamin/megamineral therapy. Pediatrics 2000;105:e18.
  185. Skorodin MS, Tenholder MF, Yetter B, et al. Magnesium sulfate in exacerbations of chronic obstructive pulmonary disease. Arch Intern Med 1995;155:496-500.
  186. Attias J, Weisz G, Almog S, et al. Oral magnesium intake reduces permanent hearing loss induced by noise exposure. Am J Otolaryngol 1994;15:26-32.
  187. Brodsky MA, Orlov MV, Capparelli EV, et al. Magnesium therapy in new-onset atrial fibrillation. Am J Cardiol 1994;73:1227-9.
  188. Rattan V, Sidhu H, Vaidyanathan S. Effect of combined supplementation of magnesium oxide and pyridoxine in calcium-oxalate stone formers. Urol Res 1994;22:161-5.
  189. Widman L, Wester PO, Stegmayr BK, et al. The dose-dependent reduction in blood pressure through administration of magnesium. A double blind placebo controlled cross-over study. Am J Hypertens 1993;6:41-5.
  190. Galloe AM, Rasmussen HS, Jorgensen LN, et al. Influence of oral magnesium supplementation on cardiac events among survivors of an acute myocardial infarction. BMJ 1993;307:585-7.
  191. Purvis JR, Cummings DM, Landsman P, et al. Effect of oral magnesium supplementation on selected cardiovascular risk factors in non-insulin-dependent diabetics. Arch Fam Med 1994;3:503-8.
  192. Plum-Wirell M, Stegmayr BG, Wester PO. Nutritional magnesium supplementation does not change blood pressure nor serum or muscle potassium and magnesium in untreated hypertension. A double-blind crossover study. Magnes Res 1994;7:277-83.
  193. Dahle LO, Berg G, Hammar M, et al. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol 1995;173:175-80.
  194. Hoogerbrugge N, Cobbaert C, de Heide L, et al. Oral physiological magnesium supplementation for 6 weeks with 1 g/d magnesium oxide does not affect increased Lp(a) levels in hypercholesterolaemic subjects. Magnes Res 1996;9:129-32.
  195. Sanjuliani AF, de Abreu Fagundes VG, Francischetti EA. Effects of magnesium on blood pressure and intracellular ion levels of Brazilian hypertensive patients. Int J Cardiol 1996;56:177-83.
  196. Lichodziejewska B, Klos J, Rezler J, et al. Clinical symptoms of mitral valve prolapse are related to hypomagnesemia and attenuated by magnesium supplementation. Am J Cardiol 1997;79:768-72.
  197. Thel MC, Armstrong AL, McNulty SE, et al. Randomised trial of magnesium in in-hospital cardiac arrest. Duke Internal Medicine Housestaff. Lancet 1997;350:1272-6.
  198. Starobrat-Hermelin B, Kozielec T. The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactivity disorder (ADHD). Positive response to magnesium oral loading test. Magnes Res 1997;10:149-56.
  199. Walker AF, De Souza MC, Vickers MF, et al. Magnesium supplementation alleviates premenstrual symptoms of fluid retention. J Womens Health 1998;7:1157-65.
  200. Facchinetti F, Borella P, Sances G, et al. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol 1991;78:177-81.
  201. Facchinetti F, Sances G, Borella P, et al. Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium. Headache 1991;31:298-301.
  202. Mauskop A, Altura BT, Cracco RQ, Altura BM. Intravenous magnesium sulphate relieves migraine attacks in patients with low serum ionized magnesium levels: a pilot study. Clin Sci (Lond) 1995;89:633-6.
  203. Mauskop A, Altura BT, Cracco RQ, et al. Intravenous magnesium sulfate relieves cluster headaches in patients with low serum ionized magnesium levels. Headache 1995;35:597-600.
  204. Mauskop A, Altura BT, Cracco RQ, et al. Deficiency in serum ionized magnesium but not total magnesium in patients with migraines. Possible role of ICa2+/IMg2+ ratio. Headache 1993;33:135-8.
  205. Yamori Y, Nara Y, Mizushima S, et al. Nutritional factors for stroke and major cardiovascular diseases: international epidemiological comparison of dietary prevention. Health Rep 1994;6:22-7.
  206. Lasserre B, Spoerri M, Moullet V, et al. Should magnesium therapy be considered for the treatment of coronary heart disease? II. Epidemiological evidence in outpatients with and without coronary heart disease. Magnes Res 1994;7:145-53.
  207. Witteman JC, Grobbee DE, Derkx FH, et al. Reduction of blood pressure with oral magnesium supplementation in women with mild to moderate hypertension. Am J Clin Nutr 1994;60:129-35.
  208. Hill J, Micklewright A, Lewis S, et al. Investigation of the effect of short-term change in dietary magnesium intake in asthma. Eur Respir J 1997;10:2225-9.
  209. Lima M, Cruz T, Pousada JC, et al. The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care 1998;21:682-6.
  210. de Valk HW, Verkaaik R, van Rijn HJ, et al. Oral magnesium supplementation in insulin-requiring Type 2 diabetic patients. Diabet Med 1998;15:503-7.
  211. Preuss HG, Gondal JA, Lieberman S. Association of macronutrients and energy intake with hypertension. J Am Coll Nutr 1996;15:21-35.
  212. Scheen AJ. Perspective in the treatment of insulin resistance. Hum Reprod 1997;12:63-71.
  213. Durlach J, Bac P, Durlach V, et al. Magnesium status and ageing: an update. Magnes Res 1998;11:25-42.
  214. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  215. Meacham SL, Taper LJ, Volpe SL. Effect of boron supplementation on blood and urinary calcium, magnesium, and phosphorus, and urinary boron in athletic and sedentary women. Am J Clin Nutr 1995;61:341-5.
  216. Whitney E, Cataldo CB, Rolfes SR, eds. Understanding Normal and Clinical Nutrition. Belmont, CA: Wadsworth, 1998.
  217. Young DS. Effects of Drugs on Clinical Laboratory Tests 4th ed. Washington: AACC Press, 1995.
  218. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  219. McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
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