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Department of Health and Human Services
Centers for Disease Control and Prevention


Vaccines & Immunizations

Vaccines and Preventable Diseases:

Smallpox Vaccination

The smallpox vaccine helps the body develop immunity to smallpox. The smallpox vaccine contains the “live” vaccinia virus—not dead virus like many other vaccines. For that reason, the vaccination site must be cared for carefully to prevent the virus from spreading. Also, the vaccine can have side effects. Currently, the United States has a big enough stockpile of smallpox vaccine to vaccinate everyone in the U.S. in the event of a smallpox emergency. More...

Smallpox vaccination

What You Should Know

About the Disease

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Vaccine Information

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Vaccine Safety

As with all vaccines, there can be minor reactions, including pain and redness at the injection site, headache, fatigue or a vague feeling of discomfort.

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Who Should Not be Vaccinated?

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For Health Professionals

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This page last modified on April 25, 2011
Content last reviewed on May 13, 2009
Content Source: National Center for Immunization and Respiratory Diseases

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Vaccines and Immunizations