CDISC ADaM ControlledTerminology CDISC ADaM Controlled Terminology, 2011-01-07 CDISC ADaM Controlled Terminology Date Imputation Flag: Indicates the level of imputation reflected in a date value. Day Imputed: Day is imputed. Day Imputed Month Imputed: Month and day are imputed. Month Day Imputed Year Imputed: Entire date (year, month and day) is imputed. Year Month Day Imputed DATEFL Date Imputation Flag CDISC ADaM Date Imputation Flag Terminology Derivation Type: Analysis value derivation method. Average: A data derivation technique which calculates a subject's average value over a defined set of records. Average of Value Derivation Technique Best Case: A data imputation technique which populates missing values with the best possible outcome. Best Case Imputation Technique Baseline Observation Carried Forward: A data imputation technique which populates missing values with the subject's nonmissing baseline observation. Baseline Observation Carried Forward Imputation Technique Best Observation Carried Forward: A data imputation technique which populates missing values with the subject's best-case nonmissing value. Best Observation Carried Forward Imputation Technique Endpoint: A data derivation technique which calculates a subject's analysis end point value. Endpoint Value Derivation Technique Interpolation: A method of imputation involving a missing value that is between known values and is estimated by a function of those known values. Interpolation Imputation Technique Last Observation Carried Forward: A data imputation technique which populates missing values with the subject's previous nonmissing value. Last Observation Carried Forward Imputation Technique Maximum: A data derivation technique which calculates a subject's maximum value over a defined set of records. Maximum Value Derivation Technique Minimum: A data derivation technique which calculates a subject's minimum value over a defined set of records. Minimum Value Derivation Technique Maximum Likelihood: A data imputation technique which populates missing values with estimates that maximize the probability of observing what has in fact been observed. Maximum Likelihood Estimation Mean of Other Group: A data imputation technique which populates missing values with the mean value from a comparator or reference group. Mean of Other Group Imputation Technique Mean Observed Value in a Group: A data imputation technique which populates missing values with the mean value observed in a group of subjects. Mean Observed Value in a Group Imputation Technique Penultimate Observation Carried Forward: A data imputation technique which populates missing values with the subject's next-to-last nonmissing value. Penultimate Observation Carried Forward Imputation Technique Screening Observation Carried Forward: A data imputation technique which populates missing values with the subject's nonmissing screening observation. Screening Observation Carried Forward Imputation Technique Worst Case: A data imputation technique which populates missing values with the worst possible outcome. Worst Case Imputation Technique Worst Observation Carried Forward: A data imputation technique which populates missing values with the subject's worst-case nonmissing value. Worst Observation Carried Forward Imputation Technique Worst Observed Value in a Group: A data imputation technique which populates missing values with the worst value observed in a group of subjects. Worst Observed Value in a Group Imputation Technique DTYPE Derivation Type CDISC ADaM Derivation Type Terminology Parameter Type: Indicates whether the parameter is derived as a function of one or more other parameters. Derived: Indicates that a parameter is derived as a function of one or more other parameters. Derived Flag PARAMTYP Parameter Type CDISC ADaM Parameter Type Terminology Time Imputation Flag: Indicates the level of imputation reflected in a time value. Hours Imputed: Entire time (hours, minutes and seconds) is imputed. Hours Minutes Seconds Imputed Minutes Imputed: Minutes and seconds are imputed. Minutes Seconds Imputed Seconds Imputed: Seconds are imputed. Seconds Imputed TIMEFL Time Imputation Flag CDISC ADaM Time Imputation Flag Terminology