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RFA on Mouse Models of Diabetic Complications (DK-01-009) The intent of this Request for Applications is to assemble a cross-disciplinary consortium to develop innovative mouse models that closely mimic the human complications of diabetes. Complications to be examined include diabetic kidney disease, retinopathy, neuropathy, micro- and macrovascular disease, peripheral vascular disease, hypertension, impaired wound healing, diabetic cardiomyopathy, abnormalities of the coagulation system, urinary tract infection, oral diseases, and altered gastrointestinal and bladder function. The first goal of this Consortium is to generate animal models that will be useful for studying disease pathogenesis, prevention, and treatment. The second goal of this Consortium is to test the role of candidate genes or chromosomal regions that emerge from genetic studies of human diabetic complications, particularly diabetic kidney disease and accelerated cardiovascular diseases. Each Unit in the Consortium must contain expertise in mouse genetic engineering, organ-specific phenotyping in the mouse, and at least one diabetic complication. The Consortium will define standards, including gene expression profiling, to validate each diabetic complication model for its similarity to human disease. The Units will utilize innovative mouse genetic engineering techniques to create diabetic mice with altered expression of potential target-organ disease genes. The Units will derive, characterize, validate, and use the models for various aspects of basic, developmental, or translational research, including testing strategies for prevention, early detection, therapy, or diagnostic imaging. This RFA will use the cooperative agreement (U01), an assistance mechanism (rather than an acquisition mechanism) in which substantial NIH scientific and/or programmatic involvement with the awardee is anticipated during performance of the activity. Letter of Intent are due February 28, 2001. The application receipt date is March 28, 2001. The full text of the RFA is available at
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