After a previous trial resulted in inaccurate assessment of diabetic sensorimotor polyneuropathy, Dyck et al used more specific diagnostic criteria and compared findings with nerve conduction studies.

Tadic and colleagues searched the MEDLINE database for patients with clinically typical dopa-responsive dystonia (DRD) and/or guanosine triphosphate cyclohydrolase I (GCH1) gene mutations from 1952 to 2011 and examined a pilot cohort of 23 outpatients with DRD and GCH1 mutations to investigate the delay in diagnosis, residual motor signs, and nonmotor signs of DRD.

Hajjar and colleagues evaluate the impact of treatment with angiotensin receptor blockers (ARBs) on the neuropathology of Alzheimer disease (AD) in the National Alzheimer Coordinating Center database, which includes aggregated data and brain autopsies from 29 AD centers throughout the United States.

In a repeated plasma and cerebrospinal fluid sampling study, Huang et al investigate dynamic changes in human plasma β-amyloid concentrations, evaluate the effects of aging and amyloidosis on these dynamics, and determine their correlation with cerebrospinal fluid β-amyloid concentrations.

In their case report, Garone and coauthors identify the cause of an adult-onset multisystemic disease with multiple deletions of mitochondrial DNA.