Treatment Options by Stage

Ductal Carcinoma In Situ (DCIS)
Lobular Carcinoma In Situ (LCIS)
Stage I, Stage II, Stage IIIA, and Operable Stage IIIC Breast Cancer
Stage IIIB, Inoperable Stage IIIC, Stage IV, and Metastatic Breast Cancer
        Stage IIIB and inoperable stage IIIC breast cancer
        Stage IV and metastatic breast cancer

A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.

Treatment of ductal carcinoma in situ (DCIS) may include the following:

• Breast-conserving surgery and radiation therapy with or without tamoxifen.
• Total mastectomy with or without tamoxifen.
• Breast-conserving surgery without radiation therapy.
• Clinical trials testing breast-conserving surgery and tamoxifen with or without radiation therapy.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with ductal breast carcinoma in situ. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Treatment of lobular carcinoma in situ (LCIS) may include the following:

• Biopsy to diagnose the LCIS followed by regular examinations and regular mammograms to find any changes as early as possible. This is called observation.
• Tamoxifen to reduce the risk of developing breast cancer.
• Bilateral prophylactic mastectomy. This treatment choice is sometimes used in women who have a high risk of getting breast cancer. Most surgeons believe that this is a more aggressive treatment than is needed.
• Clinical trials testing cancer prevention drugs.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with lobular breast carcinoma in situ. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Treatment of stage I, stage II, stage IIIA, and operable stage IIIC breast cancer may include the following:

• Breast-conserving surgery to remove only the cancer and some surrounding breast tissue, followed by lymph node dissection and radiation therapy.
• Modified radical mastectomy with or without breast reconstruction surgery.
• Sentinel lymph node biopsy followed by surgery.

Adjuvant therapy (treatment given after surgery to lower the risk that cancer will come back) may include the following:

• Radiation therapy to the lymph nodes near the breast and to the chest wall after a modified radical mastectomy.
• Chemotherapy with or without hormone therapy.
• Hormone therapy.
• Monoclonal antibody therapy with trastuzumab combined with chemotherapy.
• A clinical trial of new targeted therapies.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage I breast cancer, stage II breast cancer, stage IIIA breast cancer and stage IIIC breast cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Treatment of stage IIIB and inoperable stage IIIC breast cancer may include the following:

• Chemotherapy.
• Chemotherapy followed by surgery (breast-conserving surgery or total mastectomy), with lymph node dissection followed by radiation therapy. Additional therapy (chemotherapy, hormone therapy, or both) may be given.
• Clinical trials testing new anticancer drugs, new drug combinations, and new ways of giving treatment.

Treatment of stage IV or metastatic breast cancer may include the following:

• Hormone therapy and/or chemotherapy with or without trastuzumab.
• Monoclonal antibody therapy with trastuzumab and pertuzumab combined with chemotherapy.
• Tyrosine kinase inhibitor therapy with lapatinib combined with capecitabine.
• Radiation therapy and/or surgery for relief of pain and other symptoms.
• Bisphosphonate drugs to reduce bone disease and pain when cancer has spread to the bone.
• Clinical trials testing new chemotherapy and/or hormone therapy.
• Clinical trials of new combinations of treatments, including targeted therapy, hormone therapy, and chemotherapy.
• Clinical trials testing other approaches, including high-dose chemotherapy with stem cell transplant.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage IIIB breast cancer, stage IIIC breast cancer and stage IV breast cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.