The 2002 Grantees Meeting for the HIV RFA Programs
Etiology of Cardiovascular Complications of HIV Infection
Endothelial Dysfunction in HIV Infection
Cardiovascular Complications from Cocaine Abuse in HIV Infection
Genesis of Cardiomyopathy with HIV Infection and Alcohol Abuse
May 2-3, 2002
Sponsored by National Heart, Lung, and Blood Institute
National Institute on Drug Abuse
National Institutes of Health
Meeting Summary
Agenda
Roster
Meeting Summary
This meeting was planned, organized and conducted by
Lan-Hsiang Wang, Ph.D., of the National Heart, Lung, and Blood Institute and
Jag H. Khalsa, Ph.D., of the Center on AIDS and Other Medical Consequences of
Drug Abuse (CAMCODA), within the National Institute on Drug Abuse, NIH. A group
of nationally and internationally recognized clinicians and scientists,
supported by the NHLBI and NIDA, presented and discussed:
- Current data on the etiology and underlying pathophysiology of cardiovascular complications of HIV/AIDS, substance abuse (cocaine, alcohol), and HIV infection
- In vitro tests and in vivo models for the study of cardiovascular complications (e.g., cardiomyopathy) of HIV and substance abuse
- Endothelial function in HIV infection
- The problems of design and conducting such studies in clinical populations
Finally, the attendees made recommendations for future
research. The recommendations included the study of:
- The role of covariates in HIV-related
cardiovascular complications
- Role of other pathogens in HIV-related
cardiovascular complications
- Autoimmune mechanisms in HIV-related cardiac
conditions, particularly in combination with other pathogens
- Genetic predisposition for transition to dilated
cardiomyopathy
- Incidence, prevalence, and pathophysiology of
HIV-related cardiovascular disease in other vulnerable populations such as
women, infants, and older individuals exposed to HIV and substance abuse
- Influence of other conditions such as diabetes,
atherosclerosis, as well as lifestyle and behavior choices such as smoking and
recreational drug abuse on HIV-related cardiovascular complications
- Mechanisms of cellular injury in HIV-related
cardiovascular complications
- Interactions of viral replication, immune system
activation, inflammatory pathways, and reactive oxygen species in HIV-related
cardiovascular complications
- Metabolic/energetic mechanisms such as the role of
mitochondrial ATP production, cardiac myocyte energetics, increased reactive
oxygen species, altered oxygen utilization, and changes in gene expression in
HIV-related cardiovascular complications
- Role of highly active antiretroviral therapies
(HAART) in HIV-related cardiovascular complications
- Pharmacokinetic drug interactions between HAART and
pharmaceuticals use in the treatment of cardiac disease
- Interactions between immune cell (infected and/or
uninfected) and cardiac myocytes and their effects on recruitment mechanisms,
gene expression alterations, and cell-cell signaling events
- Role of hypothalamic-pituitary-adrenal axis in HIV
progression and HIV-related cardiovascular complications
- Pre-clinical investigations for therapies for
HIV/AIDS-related cardiovascular complications
- Animal models for studying the effects of
antiretroviral and immunorestorative therapies on HIV-related cardiovascular
complications
- Animal models for testing optimal therapies for the
treatment of HIV-related cardiovascular complications
- Therapeutics and prevention trials for
HIV/AIDS-related cardiovascular complications
- Optimal therapies for treating HIV-related
cardiomyopathy considering whether these therapies should be different from
other forms of cardiomyopathy
- Possibility and advantage of early intervention for
HIV-related cardiovascular complications
- Alternative therapies (e.g., anti-oxidants,
immunomodulators, nutritional therapies) for HIV-related cardiovascular
complications
Agenda |
|
Thursday, May 2,
2002
8:00 a.m. |
Registration |
8:30
a.m. |
Welcome
and Introduction
Lan-Hsiang Wang, NHLBI
Jag H. Khalsa, NIDA
Hannah H. Peavy, NHLBI
Sandra Colombini Hatch, NHLBI |
8:44
a.m. |
Lance
Terada (1)
University of Texas Southwestern
Effect of HIV Tat on
Endothelial Cell Function |
9:00
a.m. |
Mitchell
Finkel (16)
West Virginia University
P38 MAP Kinase Regulates
Negative Inotropic Effect of HIV gp120 on Cardiac Myocytes through Troponin I
Phosphorylation |
9:20
a.m. |
Jian-Feng
Wang (3)
Beth Israel Deaconess Medical Center
Functional Studies of
HIV-Tat Effects on Endothelium |
9:40
a.m. |
Winnie
Henderson (4)
Oregon Health Sciences University
HIV-1 vpu and tat
Modulate Endothelial Cell-B Lymphoma Cell Interactions: Implications for
AIDS-Associated Non-Hodgkin's Lymphoma |
10:00 a.m. |
Break |
10:20 a.m. |
John Ho (5)
Cornell University
HIV-1 Activates Innate Immune Cells via Toll-Like
Receptor 2 |
10:40 a.m. |
Emily D.
Overholser (6)
Johns Hopkins University
Mechanisms of Endothelial
Cell Dysfunction in SIV Infection |
11:00 a.m. |
Lingjun Zhao
(7)
Saint Louis University Medical Center
Regulation of Myosin Light
Chain Phosphorylation by HIV-1 Vpr |
11:20 a.m. |
Changyi Chen
(8)
Baylor College of Medicine
HIV-1 gp120 Down-Regulates Endothelial
Nitric Oxide Synthase (eNOS) Expression in Human Endothelial Cells |
11:40 a.m. |
Kwang Sik Kim
(9)
Johns Hopkins University
Gp120 Induces Cytotoxicity of Human Brain
Microvascular Endothelial Cells |
12:00 noon |
Lunch |
1:00
p.m. |
Poster
Session (Atrium)
Posters will be displayed from 8:30 a.m. until 5 p.m.
Poster presenters with odd numbers will be present from 1 p.m. to 1:50 p.m.
Poster presenters with even numbers will be present from 1:50 p.m. to 2:40 p.m.
Harris McFerrin (2)--poster presentation
only
Tulane University
Molecular Mechanism of Tat-Induced
Angiogenesis |
2:40 p.m. |
Break |
3:00
p.m. |
Douglas
Larson (10)
University of Arizona
Dilated Cardiomyopathy in Murine
Acquired Immunodeficiency Syndrome
(MAIDS) |
3:20
p.m. |
Ronald
Watson (11)
University of Arizona
Selenium Supplementation
Decreases Coxsackievirus Heart Disease During
Murine AIDS |
3:40
p.m. |
J. Bruce
Sundstrom (12)
Emory University
An in vitro Model for Investigating
the Role of Mast Cells in Mechanisms of Increased Fibrosis Associated with
AIDS-Related Cardiomyopathies |
4:00 p.m. |
Debasis Mondal
(13)
Tulane University
Synergistic Effects of Cocaine and the
Inflammatory Cytokines in
Modulating Vascular Endothelial Cell Function
|
4:20
p.m. |
Guha
Krishnaswamy (14)
East Tennessee State University
Role of the
Inflammatory Network in Cocaine and HIV-Mediated
Atherogenesis |
4:40
p.m. |
Shenghan
Lai (17)
Johns Hopkins University
Association of Cocaine Use With
Coronary Calcification in Injecting Drug
Users in Baltimore |
5:00
p.m. |
Recommendations for Future Directions
Ronald Watson |
5:20 p.m. |
Conclusion of Today's
Program |
Friday, May 3, 2000
8:30 a.m. |
Milan Fiala
(15)
University of California Los Angeles
(A) Human Immunodeficiency
Virus Type 1 Enters Brain and Coronary Endothelia by Macropinocytosis Dependent
upon Lipid Rafts.
(B) Cocaine Binds to a G-Protein Coupled Receptor,
Signals and Restructures Coronary Artery Endothelial Cells. |
8:50 a.m. |
John Bauer
(18)
Ohio State University
Cocaine Induced Cardiotoxicity in Mice |
9:10 a.m. |
Roy Sutliff
(19)
Emory University
Cocaine Administration Increases LV Mass in HIV-1
Transgenic Mice |
9:30 a.m. |
Sonia Flores
(20)
University of Colorado
Evidence of Inflammation in
Tat-Transgenic Mice |
9:50 a.m.
|
John
Bauer (21)
Ohio State University
Mechanistic Studies of Retrovirus
Related Cardiac Dysfunction: the Murine AIDS Model and Human HIV Infection |
10:10
a.m. |
Douglas
Wallace (22)
Emory University
Ethanol and AIDS Cardiomyopathy: A
Mitochondrial Connection? |
10:30
a.m. |
Break |
10:50
a.m. |
Paul
Jolicoeur (23)
Clinical Research Institute of Montreal
Studies of
Cardiac Disease in HIV-1 Transgenic Mice |
11:10 a.m.
. |
William
Lewis (24)
Emory University
Combined Antiretroviral Therapy Causes
Cardiomyopathy and Elevates
Plasma Lactate in Transgenic AIDS Mice |
11:30
a.m. |
Richard
Shannon (25)
New England Regional Primate Research Center
Cellular
Pathways Involved in Myocardial Injury in Simian AIDS: Role of
Cytokines,
Inducible Nitric Oxide, and CD95 |
11:50 a.m. |
Milan Fiala
(26)
University of California Los Angeles
HIV-1 Envelope Protein gp120
Induces Cardiomyocyte Apoptosis and Is Associated with HIV-1
Cardiomyopathy |
12:10 p.m. |
Neil Bowles
(27)
Baylor College of Medicine
The Pathogenesis of Heart Disease in
HIV-Infected Children
|
12:30
p.m. |
Closing
Remarks |
12:40 p.m. |
Adjournment of
Meeting |
Roster |
|
Aftab A. Ansari, Ph.D.
Departments of Pathology
and Laboratory Medicine
Winship Cancer Center,
Room B4107
Emory University School of Medicine
1365B Clifton Road
Atlanta, GA 30322
pathaaa@emory.edu |
Sheila A. Barber, Ph.D.
Assistant Professor
Division of Comparative Medicine
Johns Hopkins
University School of Medicine
Jefferson Street Building, Room 3-127
600
North Wolfe Street
Baltimore, MD 21287
sabarber@jhmi.edu |
John A. Bauer, Ph.D.
Center
for Developmental
Pharmacology and Toxicology
Children's Research
Institute
700 Children's Drive
Columbus, OH 43205
BauerJ@pediatrics.ohio-state.edu |
Neil E. Bowles, Ph.D.
Assistant Professor
Section of Cardiology
Department of Pediatrics
Baylor College of Medicine
Room 333E
1 Baylor Plaza
Houston, TX
77030
nbowles@bcm.tmc.edu |
Changyi J. Chen, M.D., Ph.D.
Professor of Surgery
Michael E. DeBakey Department of Surgery
Baylor
College of Medicine
6550 Fannin, SM 1661
Houston, TX 77030
jchen@bcm.tmc.edu |
Adela Cota-Gomez, Ph.D.
Webb-Waring Institute
Health Sciences Center
Box C321
4200 East
Ninth Avenue
Denver, CO 80262
adela.cota-gomez@uchsc.edu |
Milan Fiala, M.D.
Cardiovascular Research Lab
UCLA, 3645 MRL
675 Charles Young Drive
South
Los Angeles, CA 90095-1760
fiala@ucla.edu |
Mitchell S. Finkel, M.D. FACP,
FACC
Professor and Vice-Chairman
Department of Medicine
Professor of Physiology and Pharmacology
West Virginia University
Cardiology
Medical Center Drive
Morgantown, WV 26506-9157
mfinkel@hsc.wvu.edu |
Sonia Flores, Ph.D.
Webb-Waring Institute
Health Sciences Center
University of Colorado
4200 E Ninth Ave., Box C321
Denver, CO 80262
SONIA.FLORES@UCHSC.EDU |
Jerome E. Groopman, M.D.
Professor of Medicine
HIM Building, Room 351
Harvard Medical School
4 Blackfan Circle
Boston, MA 02115
jgroopma@caregroup.harvard.edu
|
Sandra Colombini Hatch, M.D.
Division of Lung Diseases
National Heart, Lung, and Blood Institute
Two
Rockledge Center, Room 10124
6701 Rockledge Drive, MSC 7952
Bethesda,
MD 20892-7952
hatchs@nhlbi.nih.gov |
Winnie W. Henderson, M.S.
Department of Molecular Microbiology and Immunology
Basic Sciences
Building, Room 6564
Oregon Health Sciences University
Mail Code
L220
3181 SW Sam Jackson Park Road
Portland, OR 97201
hendersw@ohsu.edu |
John L. Ho, M.D.
Weill
College of Medicine
Cornell University
Visiting Scientist
Aaron
Diamond AIDS Research Center
Room 711
455 First Avenue
New York, NY
10016
jlho@adarc.adarc.org |
Paul Jolicoeur, M.D., Ph.D.
Laboratory of Molecular Biology
Department of Microbiology and
Immunology
Clinical Research Institute of Montreal
110 Avenue des Pins,
Ouest
Montréal, Québec, Canada H2W 1R7
jolicop@ircm.qc.ca |
Jag H. Khalsa, Ph.D.
Health
Scientist Administrator
Center on AIDS and Other Medical Consequences of
Drug Abuse
National Institute on Drug Abuse
National Institutes of
Health
Neuroscience Center, Room 5198
MSC 9593
6001 Executive
Boulevard
Bethesda, MD 20892-9593
jk98p@nih.gov |
Kwang Sik Kim, M.D.
Pediatric
Infectious Diseases
Johns Hopkins University
School of Medicine
600
North Wolfe Street, Park 256
Baltimore, MD 21287
kwangkim@jhmi.edu |
Guha Krishnaswamy, M.D.
Department of Medicine
East Tennessee State University
Johnson City, TN
37614-0622
krishnas@ACCESS.ETSU.EDU |
Shenghan Lai, M.D.
Epidemiology, E6141
Johns Hopkins
615 North Wolfe Street
Baltimore,
MD 21205
shlai@jhsph.edu |
| Douglas F. Larson, Ph.D.
School of Medicine
University of Arizona
Tucson, AZ 85724
dflarson@u.arizona.edu |
William Lewis, M.D.
Department
of Pathology
Room 7117 WMRB
Emory University School of Medicine
1639 Pierce Drive
Atlanta, GA 30322
wlewis@emory.edu |
|
Joao Lima, M.D.
Cardiology
Division
Department of Medicine
School of Medicine
Johns Hopkins
University
600 North Wolfe Street
Baltimore, MD 21287
jlima@jhmi.edu |
|
Kai Liu, M.D.
Department of
Medicine
East Tennessee State University
James H. Quillen College of
Medicine
Box 70622
Johnson City, TN 37614-0622
liuk@access.etsu.edu |
|
Harris McFerrin, M.S.
Microbiology Department
Room 5704, Box SL-38
Tulane University
1430
Tulane Avenue
New Orleans, LA 70112
Mharris1@tulane.edu |
| Michael J. Mihm, Ph.D.
Division of Pharmacology
College of Pharmacy
The Ohio State
University
411 Riffe Building
500 West 12th Avenue
Columbus, OH
43210
mihm.2@osu.edu |
Debasis Mondal, Ph.D.
Department of Pharmacology
Tulane University School of Medicine
New
Orleans, LA 70112
dmondal@tulane.edu |
Ashlee Moses, Ph.D.
Vaccine
and Gene Therapy Institute
Oregon Health Sciences University
505 NW
185th Avenue
Beaverton, OR 97006
mosesa@ohsu.edu |
Emily Overholser, B.S.
Division of Comparative Medicine
Johns Hopkins University
Jefferson
Street Building, Room 3-127
600 North Wolfe Street
Baltimore, MD
21287
eoverhol@mail.jhmi.edu
|
Pierre Paradis, Ph.D.
Institut
de Recherches Cliniques
de Montreal
110 avenue de Pins Ouest
Montreal, Quebec
Canada, H2W 1R7
Pierre_Paradis@ircm.qc.ca |
Lisa Parvis, B.S.
Division of
Comparative Medicine
Johns Hopkins University
Jefferson Street
Building, Room 3-127
600 North Wolfe Street
Baltimore, MD 21287
lmp@hotmail.com |
Hannah H. Peavy, M.D.
AIDS/TB
Scientific Research Group
Lung Biology and Disease Program
Division of
Lung Diseases
National Heart, Lung, and Blood Institute
Two Rockledge
Centre, Suite 10018
6701 Rockledge Drive, MSC 7952
Bethesda, MD
20892-7952
PeavyH@NHLBI.NIH.GOV
|
Scott Raidel, M.S.
Department
of Pathology
Room 7117 WMRB
Emory University School of Medicine
1639 Pierce Drive
Atlanta, GA 30322
sraidel@emory.edu |
Richard P. Shannon, M.D.
Department
of Medicine
Alletheny General Hospital
320 East North Avenue
Pittsburgh, PA 15212
RSHANNON@wpahs.org |
J. Bruce Sundstrom, Ph.D.
Department of Pathology
and Laboratory Medicine
Emory University School
of Medicine
Winship Cancer Center, Room B4337
1365B Clifton Road
Atlanta, GA 30322
jsundst@emory.edu
|
Roy Sutliff, Ph.D.
Department
of Pathology
Room 7117 WMRB
Emory University School of Medicine
1639 Pierce Drive
Atlanta, GA 30322
rsutlif@emory.edu |
Lance S. Terada, M.D.
University of Texas Southwestern, and
The Dallas Veterans Affairs Medical
Center
Mail Code 151
4500 South Lancaster
Dallas, TX 75216
Lance.Terada@med.va.gov |
Douglas C. Wallace, Ph.D.
Center for Molecular Medicine
Emory University School of Medicine
1462
Clifton Road, Room 420
Atlanta, GA 30322
dwallace@Gen.Emory.Edu |
Jian-Feng Wang, Ph.D.
Division
of Experimental Medicine
Harvard Institutes of Medicine, # 342
4
Blackfan Circle
Boston, MA 02115
jwang2@caregroup.harvard.edu
|
Lan-Hsiang Wang, Ph.D.
Division of Heart and Vascular Diseases
National Heart, Lung, and Blood
Institute
National Institutes of Health
Two Rockledge Centre, Room
9206
6701 Rockledge Drive, MSC 7940
Bethesda, MD 20892-7940
LW72F@NIH.GOV |
Khaled Zerria, Ph.D.
Division of
Infectious Diseases
Cornell University, Room A479
1300 York Avenue
New York, NY 10021
zerria_khaled@excite.com |
Ling-Jun Zhao, Ph.D.
Institute for Molecular Virology
St. Louis University Medical Center
3681 Park Avenue
St. Louis, MO 63110
zhaol@slu.edu |
|
|
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