What is TARGET? The Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative seeks to harness the power of modern genomics technologies to rapidly identify valid therapeutic targets in childhood cancers.
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The genetic landscape of high-risk neuroblastoma
January 20, 2013
TARGET investigators used next generation whole genome, exome, and transcriptome sequencing to examine 240 cases from patients with metastatic high-risk neuroblastoma. Read more.
The molecular genetic makeup of acute lymphoblastic leukemia
December 8, 2012
In this review, Dr. Charles Mullighan surveys the large collection of genetic alterations discovered through the genomic profiling of childhood ALL and explains how they may be used to improve patient outcomes. Read more.
Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from The Children’s Oncology Group TARGET Project
December 4, 2012
TARGET researchers sequenced the tyrosine kinome and downstream signaling genes in 45 high-risk pediatric ALL cases with activated kinase signaling, including Ph-like ALL, to establish the incidence of tyrosine kinase mutations in this cohort. Read more.
Learn more about TARGET through these multimedia resources:
Get the most current data from TARGET's projects. Comprehensive access to TARGET datasets, including genomic characterization, full clinical information, and sequencing files, is available through the TARGET Data Matrix. Visit the TARGET Data Portal for more information.
Acute Lymphoblastic Leukemia (ALL)
Acute Myeloid Leukemia (AML)
Kidney Tumors
Neuroblastoma
Osteosarcoma
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The collaborative network of researchers is led by:
Office of Cancer Genomics (NCI)
Cancer Therapy Evaluation Program (NCI)
Children's Oncology Group
Data Coordinating Center (NCI)
Map of the TARGET collaborative network
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HHS
NIH
USA
