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Office of Population Genomics

Research Programs

• GARNET
  GARNET (Genomics and Randomized Trials Network, or Genome-wide Association Research Network into Effects of Treatment) is a series of genome-wide association studies of treatment response in randomized clinical trials that looks to identify genetic variants associated with response to treatments for conditions of clinical or public health significance.
  
  
• eMERGE
  The eMERGE (Electronic Medical Records and Genomics) Network is a five-member consortium formed to develop, disseminate, and apply approaches to research that combine DNA biorepositories with electronic medical record (EMR) systems for large-scale, high-throughput genetic research.
  
  
• PhenX
  The goal of PhenX is to develop consensus measures for phenotypes and exposures for use in genome-wide association studies (GWAS). PhenX will to identify up to 20 domains of high research and public health significance and then develop and disseminate 15 standard measures for each domain. The toolkit of phenotype and exposure measures produced by PhenX will facilitate integrated design and analysis of GWA studies as well as other genomics and epidemiology based studies. The PhenX External Scientific Panel met on June 23, 2010. The minutes and recommendations from the conference call can be found here.
  
  
• Population Architecture using Genomics and Epidemiology (PAGE)
  The goal of PAGE is to follow up promising genetic variants identified from genome-wide association studies in large, well-characterized epidemiological cohorts, with the aim of widespread sharing of the resulting population-based descriptive and association data to accelerate the understanding of genes related to complex diseases.

Past OPG Research Programs

• The Genetic Association Information Network (GAIN)
  Supported a series of Genome-Wide Association Studies (GWAS) designed to identify specific points of DNA variation associated with the occurrence of a particular common disease.
  
  
• The Genes, Environment and Health Initiative (GEI)
  Supported research to understand the genetic contributions and gene-environment interactions in common disease.
  
  
• GENEVA [genevastudy.org] - Part of the Genetics Program of GEI, GENEVA (Gene Environment Association Studies) is using rapidly evolving technologies in Genome-Wide Association Studies (GWAS) to find genetic risk factors in common conditions, such as tooth decay, heart disease, cancer and diabetes, and assess their interplay with non-genetic risk factors.
  
  
• Making Every Voice Count: Public Consultation on Genetics, Environment, and Health
  The goal of Making Every Voice Count, a project conducted by the Genetics & Public Policy Center of Johns Hopkins University [dnapolicy.org], was to obtain wide societal input to inform the design and implementation of a possible large U.S.-based longitudinal cohort study of the role of genes and environment in health and disease. This research project, initially funded for two years, resulted in the collection of rich and detailed data on the public's level of willingness to participate in such research, and the factors that influence these attitudes. A follow-up project is now underway to gather additional data on some of these issues. This study was conducted with partial support from the Ethical, Legal and Social Implications (ELSI) Research Program.
  
  

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Last Updated: June 18, 2012