Talking Glossary of Genetic Terms

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Eric D. Green, M.D., Ph.D. defines Fluorescence In Situ Hybridization (FISH)

Fluorescence In Situ Hybridization (FISH)

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Fluorescence in situ hybridization (FISH) is a laboratory technique for detecting and locating a specific DNA sequence on a chromosome. The technique relies on exposing chromosomes to a small DNA sequence called a probe that has a fluorescent molecule attached to it. The probe sequence binds to its corresponding sequence on the chromosome.

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