AHRQ Evidence Reports

New Evidence Report: Closing Multigene Panels in Prostate Cancer Risk Assessment

The following provides a list of Evidence-Based Practice Center (EPC) reports starting with the most recent. These reports are used for informing and developing coverage decisions, quality measures, educational materials and tools, guidelines, and research agendas. For more information on EPCs including a list of archived reports, visit the AHRQs Web site.

209.   Closing Multigene Panels in Prostate Cancer Risk Assessment

208.   Closing the Quality Gap: Revisiting the State of the Science Series

• The Patient-centered Medical Home
• Quality Improvement Interventions to Address Health Disparities
• Bundled Payment: Effects on Health Care Spending and Quality
• Public Reporting as a Quality Improvement Strategy
• Medication Adherence Interventions: Comparative Effectiveness

207.   Allocation of Scarce Resources During Mass Casualty Events

206.   Enabling Patient-Centered Care through Health Information Technology (Health IT)

205.   Diagnosis and Management of Febrile Infants (0–3 Months)

204.   An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

203.   Enabling Health Care Decisionmaking Through Clinical Decision Support and Knowledge Management

202.   Transition of Care for Acute Stroke and Myocardial Infarction Patients: From Hospitalization to Rehabilitation, Recovery, and Secondary Prevention

201.   Enabling Medication Management Through Health Information Technology (Health IT)

200.   Safety of Probiotics Used to Reduce Risk and Prevent or Treat Disease

199.   Health Literacy Interventions and Outcomes: An Updated Systematic Review

198.   Management of Acute Otitis Media: Update

197.   Alcohol Consumption and Cancer Risk: Understanding Possible Causal Mechanisms for Breast and Colorectal Cancers

196.   Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-based Drugs: Addendum—Updating the Report and Reanalysis

195.   Inhaled Nitric Oxide in Preterm Infants

194.   Complementary and Alternative Therapies for Back Pain II

193.   Alzheimer's Disease and Cognitive Decline

192.   Lactose Intolerance and Health

191.   Vaginal Birth After Cesarean: New Insights

190.   Enhancing Use and Quality of Colorectal Cancer Screening

189.   Exercise-induced Bronchoconstriction and Asthma

188.   Impact of Consumer Health Informatics Applications

187.   Treatment of Overactive Bladder in Women

186.   Family History and Improving Health

185.   Diagnosis and Management of Ductal Carcinoma In Situ (DCIS)

184.   Treatment of Common Hip Fractures

183.   Vitamin D and Calcium: Systematic Review of Health Outcomes

181.   Outcomes of Community Health Worker Interventions

180.   Outcomes of Genetic Testing in Adults with a History of Venous Thromboembolism

179.   Clinical Utility of Cancer Family History Collection in Primary Care

177.   Complementary and Alternative Medicine in Back Pain Utilization

175.   Barriers and Drivers of Health Information Technology Use for the Elderly, Chronically Ill, and Underserved

174.   Management of Chronic Hepatitis B

173.   Integration of Mental Health/Substance Abuse and Primary Care

172.   HER2 Testing to Manage Patients with Breast or Other Solid Tumors

170.   Effectiveness of Weight Management Programs in Children and Adolescents

169.   Bariatric Surgery in Women of Reproductive Age: Special Concerns for Pregnancy

168.   Outcomes of Maternal Weight Gain

167.   Effectiveness of Assisted Reproductive Technology

166.   Diabetes Education for Children With Type 1 Diabetes Mellitus and Their Families

165.   Hydroxyurea for the Treatment of Sickle Cell Disease

164.   Utility of Monitoring Mycophenolic Acid in Solid Organ Transplant Patients

163.   Carbohydrate and Lipid Disorders and Relevant Considerations in Persons with Spinal Cord Injury

162.   Therapeutic Management, Delivery, and Postpartum Risk Assessment and Screening in Gestational Diabetes

161.   Prevention of Fecal and Urinary Incontinence in Adults

160.   Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes

159.   Collection and Use of Cancer Family History in Primary Care

158.   Effectiveness and Safety of Vitamin D in Relation to Bone Health

157.   Treatment of Primary and Secondary Osteoarthritis of the Knee

156.   Antiretroviral (ARV) Drug Resistance in the Developing World

155.   Meditation Practices for Health: State of the Research

154.   Management of Uterine Fibroids: An Update of the Evidence

153.   Breastfeeding and Maternal and Infant Health Outcomes in Developed Countries

152.   Cardiac Resynchronization Therapy and Implantable Cardiac Defibrillators in Left Ventricular Systolic Dysfunction

151.   Nurse Staffing and Quality of Patient Care

150.   Hereditary Nonpolyposis Colorectal Cancer: Diagnostic Strategies and Their Implications

149.   Effectiveness of Continuing Medical Education

148.   The Uses of Heparin To Treat Burn Injury

147.   The Effectiveness of Different Methods of Toilet Training for Bowel and Bladder Control

146.   Testing for Cytochrome P450 Polymorphisms in Adults With Non-Psychotic Depression Treated With Selective Serotonin Reuptake Inhibitors (SSRIs)

145.   Genomic Tests for Ovarian Cancer Detection and Management

144.   Comparison of Endovascular and Open Surgical Repairs for Abdominal Aortic Aneurysm

143.   Management of Small Cell Lung Cancer

142.   Testing for BNP and NT-proBNP in the Diagnosis and Prognosis of Heart Failure

141.   Pediatric Anthrax: Implications for Bioterrorism Preparedness

140.   Tobacco Use: Prevention, Cessation, and Control

139.   Multivitamin/Mineral Supplements and Prevention of Chronic Disease

138.   Cancer Care Quality Measures: Diagnosis and Treatment of Colorectal Cancer

137.   Cancer Care Quality Measures: Symptoms and End of Life Care

136.   Value of the Periodic Health Evaluation

135.   Management of Eating Disorders

134.   B Vitamins and Berries and Age-Related Neurodegenerative Disorders

133.   Cesarean Delivery on Maternal Request

132.   Costs and Benefits of Health Information Technology

131.   Telemedicine for the Medicare Population—Update

130.   Management of Adnexal Mass

129.   Diagnosis and Management of Work-Related Asthma

128.   Diagnosis, Prognosis, and Therapy of Impaired Glucose Tolerance and Impaired Fasting Glucose

127.   Acute Stroke: Evaluation and Treatment

125.   Manifestations and Management of Chronic Insomnia in Adults

124.  Update on Acute Bacterial Rhinosinusitis

123.   Post-Myocardial Infarction Depression

122.   Knowledge and Access to Information on Recruitment of Underrepresented Populations to Cancer Clinical Trials

121.   Use of Spirometry for Case Finding, Diagnosis, and Management of Chronic Obstructive Pulmonary Disease (COPD)

117.   Effects of Omega-3 Fatty Acids on Eye Health

116.   Effects of Omega-3 Fatty Acids on Mental Health

115.   Effects of Omega-3 Fatty Acids on Organ Transplantation

114.   Effects of Omega-3 Fatty Acids on Cognitive Function with Aging, Dementia, and Neurological Diseases

113.   Effects of Omega-3 Fatty Acids on Cancer

111.   Wound-Healing Technologies: Low-Level Laser and Vacuum-Assisted Closure

110.   End-of-Life Care and Outcomes

108.   Melatonin for Treatment of Sleep Disorders

107.   Preventing Violence and Related Health-Risking Social Behaviors in Adolescents

106.   Cardiac Resynchronization Therapy for Congestive Heart Failure

104.   Celiac Disease

103.   Pharmacological and Surgical Treatment of Obesity

102.   Effectiveness of Behavioral Interventions to Modify Physical Activity Behaviors in General Populations and Cancer Patients and Survivors

101.   Economic Incentives for Preventive Care

100.   Criteria to Determine Disability Related to Multiple Sclerosis

99.   Community-Based Participatory Research

98.   Islet Transplantation in Patients with Type 1 Diabetes Mellitus

97.   Pharmacological Treatment of Dementia

96.   Regionalization of Bioterrorism Preparedness and Response

95.   Training of Hospital Staff To Respond to a Mass Casualty Incident

94.   Effects of Omega-3 Fatty Acids on Cardiovascular Disease

93.   Effects of Omega-3 Fatty Acids on Cardiovascular Risk Factors and Intermediate Markers of Cardiovascular Disease

92.   Effects of Omega-3 Fatty Acids on Arrhythmogenic Mechanisms in Animal and Isolated Organ/Cell Culture Studies

91.   Health Effects of Omega-3 Fatty Acids on Asthma

90.   Strategies for Improving Minority Healthcare Quality

89.   Effects of Omega-3 Fatty Acids on Lipids and Glycemic Control in Type II Diabetes and the Metabolic Syndrome and on Inflammatory Bowel Disease, Rheumatoid Arthritis, Renal Disease, Systemic Lupus Erythematosus, and Osteoporosis

88.   Effectiveness of Antimicrobial Adjuncts to Scaling and Root-Planing Therapy for Periodontitis

86.   Total Knee Replacement

85.   Hyperbaric Oxygen Therapy for Brain Injury, Cerebral Palsy, and Stroke

84.   Use of Glycated Hemoglobin and Microalbuminuria in the Monitoring of Diabetes Mellitus

79.   Diffusion and Dissemination of Evidence-based Cancer Control Interventions

78.   Best-Case Series for the Use of Immuno-Augmentation Therapy and Naltrexone for the Treatment of Cancer

77.   Management of Treatment-Resistant Epilepsy

76.   Ephedra and Ephedrine for Weight Loss and Athletic Performance Enhancement: Clinical Efficacy and Side Effects

74.   The Effect of Health Care Working Conditions on Patient Safety

73.   Criteria for Determining Disability in Infants and Children: Short Stature

72.   Criteria for Determining Disability in Infants and Children: Failure to Thrive

70.   Criteria for Determining Disability in Infants and Children: Low Birth Weight

69.   Management of Bronchiolitis in Infants and Children

68.   Diagnosis and Treatment of Deep Venous Thrombosis and Pulmonary Embolism

67.   Management of Allergic Rhinitis in the Working-Age Population

3.   Pharmacotherapy for Alcohol Dependence

The following provides a list of Evidence-Based Practice Center (EPC) technical reviews starting with the most recent. For a list of archived reports, visit the Archived Technical Reviews on AHRQ's Web site.

17.   Nutritional Research Series

• Volume 1: Application of Systematic Review Methodology to the Field of Nutrition
• Volume 2: Issues and Challenges in Conducting Systematic Reviews to Support Development of Nutrient Reference Values: Workshop Summary
• Volume 3: Reporting of Systematic Reviews of Micronutrients and Health: A Critical Appraisal
• Volume 4: Effects of Eicosapentanoic Acid and Docosahexanoic Acid on Mortality Across Diverse Settings: Systematic Review and Meta-Analysis of Randomized Trials and Prospective Cohorts

16.   Updating Systematic Reviews

15.   Consumer-Oriented Strategies for Improving Health Benefit Design: An Overview

14.   A Critical Analysis of Care Coordination Strategies for Children With Special Health Care Needs

13.   Empirical Evaluation of the Association Between Methodological Shortcomings and Estimates of Adverse Events

12.   Criteria for Distinguishing Effectiveness From Efficacy Trials in Systematic Reviews

11.   Developing a Methodology for Establishing a Statement of Work for a Policy-Relevant Technical Analysis

10.   Strategies To Support Quality-based Purchasing

9.   Closing the Quality Gap:

• Volume 1: A Critical Analysis of Quality Improvement Strategies
• Volume 2: Diabetes Mellitus Care
• Volume 3: Hypertension Care
• Volume 4: Antibiotic Prescribing Behavior
• Volume 5: Asthma Care
• Volume 6: Healthcare-Associated Infections
• Volume 7: Care Coordination

8.   Meta-regression Approaches: What, Why, When, and How?

7.   Determinants of Increases in Medicare Expenditures for Physicians' Services

6.   Current Validity of AHRQ Clinical Practice Guidelines

5.   Measures of Patient Safety Based on Hospital Administrative Data—The Patient Safety Indicators

4.   Refinement of the HCUP Quality Indicators

3.   Diagnosis of Attention-Deficit/Hyperactivity Disorder

2.   Treatment of Headache

The technology assessment program at AHRQ provides technology assessments for the Centers for Medicare & Medicaid Services (CMS). These technology assessments are used by CMS to inform its national coverage decisions for the Medicare program as well as provide information to Medicare carriers. For a list of archived reports from 1990-2002, visit the AHRQ Web site . The AHRQ Web site also provides a list of Technology Assessments In Progress .

*Not available electronically. Contact AHRQTAP@ahrq.hhs.gov for report availability.
**Report is completed, but in the process of being prepared for posting. Please check back for updates.
***PDF Help: Documents in PDF format require the Adobe Acrobat Reader®. If you experience problems with PDF documents, please download the latest version of the Reader® .

2011

• Outcomes of Sipuleucel-T Therapy

2010

• Bone Morphogenetic Protein: the State of the Evidence of On-Label and Off-Label Use
• Consideration of Evidence on Antiemetic Drugs for Nausea and Vomiting Associated with Chemotherapy or Radiation Therapy in Adults
• Diagnosis and Treatment of Secondary Lymphedema
• ECG-based Signal Analysis Technologies
• Genetic Tests for Non-cancer Diseases/Conditions: a Horizon Scan
• Quality, Regulation and Clinical Utility of Laboratory-developed Tests
• Comparative Evaluation of Radiation Treatments for Clinically Localized Prostate Cancer: an update
• Report on the Evidence Regarding Off-Label Indications for Targeted Therapies used in Cancer Treatment
• A Systematic Review of Loss-of-Heterozygosity Based Topographic Genotyping with PathfinderTG®***
• Systematic Reviews on Selected Pharmacogenetic Tests for Cancer Treatment: CYP2D6 for Tamoxifen in Breast Cancer, KRAS for anti-EGFR antibodies in Colorectal Cancer, and BCR-ABL1 for Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia

2009

• Reviews of Selected Pharmacogenetic Tests for Non-Cancer and Cancer Conditions

2008

• Evaluation of the Evidence on Benefits and Harms of Pulmonary Artery Catheter Use in Critical Care Settings
• Home Testing in Management of Chronic Diseases
• Horizon Scan of Invasive Interventions for Lower Extremity Peripheral Artery Disease and Systematic Review of Studies Comparing Stent Placement to Other Interventions
• Horizon Scan: Lipoprotein Subfractions for Identifying Patients at Increased Risks for Cardiovascular Diseases
• Methodological Issues in Evaluation of Innovative Training Approaches to Stroke Rehabilitation
• Non-Pharmacological Interventions for Post-Discharge Care in Heart Failure
• Positron Emission Tomography for Nine Cancers (Bladder, Brain, Cervical, Kidney, Ovarian, Pancreatic, Prostate, Small Cell Lung, Testicular)

2007

• Applicability of the Evidence Regarding Intensive Glycemic Control and Self-Monitored Blood Glucose to Medicare Patients with Type 2 Diabetes
• Compendia for Coverage of Off-Label Uses of Drugs and Biologics in an Anticancer Chemotherapeutic Regimen
• Cost-Effectiveness of DNA Stool Testing to Screen for Colorectal Cancer
• Decompression Therapy for the Treatment of Lumbosacral Pain
• Esophageal Doppler Ultrasound-based Cardiac Output Monitoring for Real-Time Therapeutic Management of Hospitalized Patients
• Genetic Tests for Non-Cancer Diseases/Conditions: A Horizon Scan
• Home Diagnosis of Obstructive Sleep Apnea-Hypopnea Syndrome
• Obstructive Sleep Apnea-Hypopnea Syndrome: Modeling Different Diagnostic Strategies
• Remote Cardiac Monitoring