Genomics & Health Impact Update

Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science.  To receive this update electronically every week sign-up here.

Thursday, October 11, 2012       Volume 29   Number 15

Spotlight

Outbreak Investigations

 

 

• Fighting Outbreaks with Bacterial Genomics: Case Review and Workflow Proposal.
  Cheung MK, Kwan HS. Public Health Genomics. 2012 Oct 3
• Outbreak of Mycobacterium mucogenicum Bloodstream Infections among Patients with Sickle Cell Disease in an Outpatient Setting.
  Ashraf MS, Swinker M, Augustino KL, et al. Infect Control Hosp Epidemiol. 2012 Nov;33(11):1132-6.
  • Genotyping helps identify source of clinic infection outbreak, Science Daily, October 5
• CDC Blog: Genomic Epidemiology
• Current CDC outbreak public health investigations: meningitis, salmonella, hantavirus & more
• CDC multistate meningitis outbreak investigation
• CDC report: What is the role of human genomics in acute public health investigations? (2005)
• CDC study: Genetic studies of infectious disease susceptibility on the rise but remain a relatively small field

Consumer Genomics

• 4th Annual Consumer Genetics Conference, October 3-5, 2012
• New York Genome Center: The future of consumer genetics
• Twitter archive of Consumer Genetics Conference
• CDC blog: on DTC genomics: clinical actionability will be unknown for quite some time-more data needed
• CDC survey-DTC genomics: increased consumer awareness calls for education, policy development & surveillance
• CDC paper: danger of reverse genetic exceptionalism: what happens if we give genetic info a pass from rules of evidence?

New Strategies in Public Health Genomics Beyond Newborn Screening

• New CDC Blog: New Strategies in Public Health Genomics Beyond Newborn Screening: Working meeting and action plan to save lives now

• New CDC article: Public Health Action in Genomics Is Now Needed beyond Newborn Screening
  Bowen MS, Kolor K, Dotson WD, et al. Public Health Genomics 2012 Sept 11
• Updated Evidence based Table: Genomic Tests and Family History by Levels of Evidence

Genomic Medicine Infrastructure: Training and Electronic Health Records

• A first: a medical school course on practical analysis of personal whole genome sequence
• A first: combined MD-MS Program in Genomic Medicine
• Training clinicians AND public health professionals is crucial for the success of genomics in improving health, Secretary’s Advisory Committee on Genetics, Health and Society 2011 report and recommendations [PDF 2.55 MB]
• CDC Genomic competencies for the Public Health Workforce, a decade later
• A genome-enabled electronic health record is crucial for translating complex genomic information in clinical practice
• CDC Report: Data on physician adoption of electronic health record systems in the US, 2011

October is Breast Cancer Awareness Month

• CDC feature: Learn what factors can increase your chance of getting breast cancer
• CDC feature: Learn how family history increases risk of getting breast cancer
• CDC information: Genetic testing for breast/ovarian cancer
• Watch CDC podcast on genetic testing for breast/ovarian cancer

• CDC/California Study:  Women with a family history of breast/ovarian cancer more likely to be up to date with mammography

October is Sudden Infant Death Syndrome Awareness Month

• CDC Feature: Sudden Infant Death Syndrome: learn what you can do to reduce the risk

• CDC Sudden Unexpected Infant Death Case Registry

• SIDS risk factors including having a brother or sister who had SIDS

• There is limited literature on genetics of SIDS: Since 2001, 65 genetic association studies have been conducted with no meta analyses or genome wide association studies-Check out the HuGE Navigator

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Topics of the Week

Cancer

• Getting our priorities straight: a novel framework for stakeholder-informed prioritization of cancer genomics researchEsmail LC, et al. Genet Med 2012 Oct

• A whole-blood RNA transcript-based prognostic model in men with castration-resistant prostate cancer: a prospective study
  Ross R, Galsky M, Scher H, et al. The Lancet Oncology, Early Online Publication, 9 October 2012. doi:10.1016/S1470-2045(12)70263-2

  • Prostate cancer genetic 'signatures' could predict who will have aggressive tumors, The Huffington Post, October 8

• Exploiting FOXM1-Orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis.
  Teh MT, Hutchison IL, Costea DE, et al. Int J Cancer. 2012 Oct 4. 

  • Early mouth cancer risk detected by new gene test, Medical News Today, October 8
• Prevalence and Phenotypes of APC and MUTYH Mutations in Patients With Multiple Colorectal Adenomas
  Grover S, Kastrinos F, Steyerberg EW, et al JAMA. 2012;308:485-492
  • Squaring genetic vs clinical findings in familial polyposis, Medscape, October 4 [by free subscription only]

Genomics in Practice

• Communicating inherited genetic risk between parent and child: A meta-thematic synthesis
  Rowland E & Metcalfe A Int J Nurs Stud 2012 Sep

Genomic Testing

• Clinical utility gene card for: familial polycythaemia vera
  Hussein K, et al. Eur J Hum Genet 2012 Oct

Newborn Screening

• Including the initial newborn screening bloodspot collection device serial number on birth certificates: basis and recommendations from the Secretary of Health and Human Services' Advisory Committee on Heritable Disorders in Newborns and Children
  Therrell BL & Wu C Genet Med 2012 Oct

• Rapid whole-genome sequencing for genetic disease diagnosis in neonatal intensive care units.
  Saunders CJ, Miller NA, Soden SE, et al. Sci Transl Med. 2012 Oct 3;4(154):154ra135

  • Infant DNA tests speed diagnosis of rare diseases, The New York Times, October 3

Policy

• Privacy and Progress in Whole Genome Sequencing, Presidential Commision for the Study of Bioethical Issues
  • US ethics panel reports on DNA sequencing and privacy, Nature News Blog, October 11

Public Health Sciences

• The Public Health and Policy Implications of Epigenetics and Pediatric Health Research
  Witherspoon NO, et al. Environ Health Perspect 2012 Oct;120(10):a380-a381

• Pediatric pharmacogenomics: a systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children
  Wagner J & Leeder JS Pediatr Clin North Am 2012 Oct;59(5):1017-37

• Genetics of infections, Genome Web, October [by free subscription only]

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CDC-Authored Genomics Publications

CDC authors are indicated in bold

View previous CDC-authored publications

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