Genome Technology Program

• Overview
• Related Information
• Reports
• Policies
• Funding Opportunities
• Advanced Sequencing Technology Awards
• Genome Technology Features
• Publications and Patents
• Staff

Genome Technology Program Overview

The Genome Technology program supports research to develop new methods, technologies and instruments that enable rapid, low-cost determination of DNA sequence, SNP genotyping (Genetic Variation Program) and functional genomics (broadly defined) experiments (Functional Analysis Program). Priorities include the refinement of current technologies to increase efficiency and decrease cost while maintaining or improving data quality, and the development of completely novel approaches to achieve orders-of-magnitude improvement. Integration of process steps is key to achieving these goals.

The program also supports and coordinates transfer of technology from developers to users, and promotes collaborative, multidisciplinary programs that closely integrate research projects at academic and industrial laboratories.

The National Human Genome Research Institute (NHGRI) participates in numerous trans-NIH efforts, including one on bioengineering research. The development of integrated concepts and tools for genomic research benefits from bioengineering research, methods and approaches. NHGRI supports bioengineering research through grants made in response to NHGRI program announcements and requests for application, and through NHGRI participation in trans-NIH bioengineering program announcements, such as the Bioengineering Research Grants (BRG) and Bioengineering Research Partnerships (BRP) programs and other Funding Opportunities that are listed below.

Top of page

Genome Technology Program Related Information

• Concept Papers for Two New DNA Sequencing Technology Development Programs

Top of page

Genome Technology Program Reports

• Sequencing and Re-Sequencing the Biome! July 2002
• Sequencing Technology Workshop May 13, 1998
• Sequencing Variation Workshop March 31-April 1, 1997
• Functional Analysis Workshop December 2-3, 1997

Top of page

Genome Technology Program Policies

• Principles and Guidelines for Recipients of NIH Research Grants and Contracts on Obtaining and Disseminating Biomedical Research Resources: Final Notice [ott.od.nih.gov]

Top of page

Genome Technology Program Funding Opportunities

NHGRI Funding Opportunities

RFA-HG-10-014 [grants.nih.gov]: Revolutionary Genome Sequencing Technologies The $1000 Genome (SBIR [R43/R44])
Letters of intent are due September 17, 2012, and applications are due October 17, 2012

RFA-HG-10-013 [grants.nih.gov]: Revolutionary Genome Sequencing Technologies The $1000 Genome (R21)
Letters of intent are due September 17, 2012, and applications are due October 17, 2012.

RFA-HG-10-012 [grants.nih.gov]: Revolutionary Genome Sequencing Technologies The $1000 Genome (R01)
Letters of intent are due September 17, 2012, and applications are due October 17, 2012

PAR-10-202 [grants.nih.gov]: Centers of Excellence in Genomic Science (CEGS) (P50)
This is NHGRI's signature Centers program. Forward-looking technology development is included in the goals of the program.

Many other solicitations are appropriate means for submitting genomic technology development grant applications. Please see NHGRI's Funding Opportunities page at NHGRI Funding Opportunities

Expired Grant Solicitations

Top of page

Genome Technology Program Advanced Sequencing Technology Awards

In 2004, NHGRI initiated a coordinated effort to support the development of technologies to dramatically reduce the cost of DNA sequencing, a move aimed at broadening the applications of genomic information in medical research and health care.

• Advanced Sequencing Technology Awards 2012
• New NIH/NHGRI grants to harness nanoscale technologies to cut DNA sequencing costs
  September 14, 2012 News Release
  
  

• Advanced Sequencing Technology Awards 2011
• NHGRI funds development of revolutionary DNA sequencing technologies
  August 22, 2011 News Release
  
  

• Advanced Sequencing Technology Awards 2010
• NHGRI funds development of third generation DNA sequencing technologies
  September 13, 2010 News Release
  
  

• Advanced Sequencing Technology Awards 2009
• NHGRI Uses Recovery Act Funds to Accelerate Genome Research to Improve Human Health
  October 8, 2009 Online News Feature
  
  
• Advanced Sequencing Technology Awards 2008
• NHGRI Seeks DNA Sequencing Technologies Fit for Routine Laboratory and Medical Use
  August 20, 2008 News Release
  
  
• Advanced Sequencing Technology Awards 2007
• New Grants Bolster Efforts to Generate Faster and Cheaper Tools for DNA Sequencing
  August 1, 2007 News Release
  
  
• NHGRI Aims to Make DNA Sequencing Faster, More Cost Effective
  October 4, 2006 News Release
  
  
• Advanced Sequencing Technology Awards 2005
• NHGRI Expands Effort to Revolutionize Sequencing Technologies
  August 8, 2005 Release
  
  
• Advanced Sequencing Technology Awards 2004
• NHGRI Seeks Next Generation of Sequencing Technologies
  October 14, 2004 Release

Top of page

Genome Technology Features

• July 2011: Genome Advance of the Month - Proteus: Discovering the tiniest disease-causing flaws - and improving sequencing technologies
• February 7, 2011: The Road to the $1000 Genome Via Nanopores - A Roundup of Sequencing Technology Developments
• August 2, 2010: The Road to the $1000 Genome - A Roundup of Sequencing Technology Developments

Top of page

Genome Technology Program Bibliography: Publications and Patents

NHGRI launched an ambitious program in 2004 to reduce the cost of full mammalian genome sequencing initially by 100-fold and subsequently by an additional 100-fold, aiming ultimately at about $1,000. Below, listed by Principal Investigator, are citations and links to many of the articles and patents resulting from this program and closely related research.

Genome Technology Program Publications and Patents

To view this PDF you will need Adobe Reader.

Top of page

Genome Technology Program Staff

Program Directors
Jeffery Schloss, Ph.D.
E-mail: schlossj@exchange.nih.gov

Bradley A. Ozenberger, Ph.D.
E-mail: bozenberger@mail.nih.gov

Mark Guyer, Ph.D.
E-mail: guyerm@exchange.nih.gov

Address
National Human Genome Research Institute
National Institutes of Health
5635 Fishers Lane
Suite 4076, MSC 9305
Bethesda, MD 20892-9305
Phone: (301) 496-7531
Fax: (301) 480-2770

Top of page

Last Updated: September 14, 2012