The Cancer Genome Atlas Research Network Symposium Meeting

DNA double-helix and two researchersIn November 2011, The Cancer Genome Atlas (TCGA) Research Network held its first open scientific symposium in Washington, D.C. TCGA researchers and outside investigators from around the world presented results on the use of TCGA data to make biological discoveries about cancer. The two-day meeting included lectures, collaborative workshops and poster sessions. The lectures are made freely available here and on NHGRI's YouTube channel, GenomeTV.

The National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI), two of the National Institutes of Health's 27 institutes and centers, jointly fund TCGA to use genome analysis technologies, including large-scale genome sequencing, to accelerate the understanding of the molecular basis of cancer.

Available in the table below are videos and accompanying slides from the symposium.
Also available as a video playlist on GenomeTV

Thursday, November 17, 2011

1 Opening
YouTube video Video
Lynda Chin, M.D.
University of Texas M.D. Anderson Cancer Center
2 Keynote and Q & A
YouTube video Video | Slides not available
Eric S. Lander, Ph.D.
Broad Institute
3 Session I - Lead Talk
YouTube video Video | Slides PDF file
Peter W. Laird, Ph.D., M.S.
University of Southern California Epigenome Center
4 Predicting Patient Outcomes With Chained Biological Concept Classifiers
YouTube video Video | Slides PDF file
K. James Durbin
University of California, Santa Cruz

Presenter: Daniel Edward Carlin, M.S.
University of California, Santa Cruz

5 Lessons Learned From 24 Completely Sequenced AML Genomes
YouTube video Video | Slides PDF file
Timothy Ley, M.D.
Washington University in St. Louis
6 LRpath Analysis Reveals Common Pathways Dysregulated via DNA Methylation Across Cancer Types
YouTube video Video | Slides PDF file
Maureen A. Sartor, Ph.D., M.S.
University of Michigan
7 Multi-Cancer Mutual Exclusivity Analysis of Genomic Alterations
YouTube video Video | Slides PDF file
Giovanni Ciriello, Ph.D.
Memorial Sloan-Kettering Cancer Center
8 Genome-Wide Co-Localization of Somatic Copy Number Alterations and Germline Common Variant Risk Loci in Cancer
YouTube video Video | Slides PDF file
Marcin Imielinski, M.D., Ph.D.
Broad Institute
9 Correlating Protein Phosphorylation With Genomic Alterations in Cancer
YouTube video Video | Slides PDF file
Jianjiong Gao, Ph.D.
Memorial Sloan-Kettering Cancer Center
10 Session II - Lead Talk
YouTube video Video | Slides not available
Ilya Shmulevich, Ph.D.
Institute for Systems Biology
11 Absolute Quantification of Somatic DNA Alterations in Cancer Reveals Frequent Genome Doublings in Human Cancers
YouTube video Video | Slides PDF file
Scott L. Carter, Ph.D.
Broad Institute
12 Predicting the Impact of Mutations in Cancer Using an Integrated Pathway Approach
YouTube video Video | Slides PDF file
Sam Ng
University of California, Santa Cruz
13 TCGA Computational Histopathology Pipeline Reveals Subtypes and Their Molecular Signature
YouTube video Video | Slides PDF file
Hang Chang
Lawrence Berkeley National Laboratory

Presenter: Bahram Parvin, Ph.D., M.S.
Lawrence Berkeley National Laboratory

14 Algorithms for Automated Discovery of Mutated Pathways in Cancer
YouTube video Video | Slides PDF file
Ben Raphael, Ph.D
Brown University
15 The Spectra of Somatic Mutations Across Many Tumor Types
YouTube video Video | Slides PDF file
Michael S. Lawrence, Ph.D.
Broad Institute
16 An Integrated View Into Multivariate Associations Inferred From TCGA Cancer Data
YouTube video Video | Slides PDF file
Richard Kreisberg, M.S.
Institute for Systems Biology


Wednesday, November 18, 2011

17 Session III - Lead Talk
YouTube video Video | Slides PDF file
Marco Marra, Ph.D.
British Columbia Cancer Agency
18 RetroSeq: A Tool To Discover Somatic Insertion of Retrotransposons
YouTube video Video | Slides PDF file
Elena Helman
Broad Institute
19 Patient-Specific Pathway Analysis Using PARADIGM Identifies Key Activities in Multiple Cancers
YouTube video Video | Slides PDF file
Josh Stuart, Ph.D.
University of California, Santa Cruz
20 Morphologic Analysis of Glioblastoma Identifies Morphology-Driven Clusters and Molecular Correlates Associated With Patient Survival
YouTube video Video | Slides PDF file
Lee Cooper, Ph.D.
Emory University
21 Validated Targets Associated With Curatively Treated Advanced Serous Ovarian Carcinoma
YouTube video Video | Slides PDF file
Douglas A. Levine, M.D.
Memorial Sloan-Kettering Cancer Center
22 Massively Parallel Validation of Cancer Mutations and Other Variants Identified by Whole Cancer Genome and Exome Sequencing
YouTube video Video | Slides PDF file
Georges Natsoulis, Ph.D.
Stanford University
23 SuperPathway Analyses of Luminal and Basaloid Breast Cancers From The Cancer Genome Atlas Program
YouTube video Video | Slides not available
Christopher Benz, M.D.
Buck Institute for Research on Aging
24 Session IV - Lead Talk
YouTube video Video | Slides PDF file
David Haussler, Ph.D.
University of California, Santa Cruz
25 RF-ACE for Uncovering Nonlinear Associations From Heterogeneous Cancer Data
YouTube video Video | Slides PDF file
Timo Erkkilä, M.S.
Institute for Systems Biology
26 Supporting Subtype Characterization Through Integrative Visualization of Cancer Genomics Datasets
YouTube video Video | Slides PDF file
Nils Gehlenborg, Ph.D.
Harvard Medical School
27 Uncovering the Pseudo-Subclonal Structure of Tumor Sample With Copy Number Variation Analysis of Next-Generation Sequencing Data
YouTube video Video | Slides PDF file
Yi Qiao
Boston College
28 Comparison and Validation of Somatic Mutation Callers
YouTube video Video | Slides PDF file
Andrey Sivachenko, Ph.D.
Broad Institute
29 Post-Transcriptional Regulators of microRNA Biogenesis Regulate Pathogenesis of Cancer
YouTube video Video | Slides PDF file
Pavel P. Sumazin, Ph.D.
Columbia University
30 Neuroimaging Predictors of Survival, Pathology, and Molecular Profiles in TCGA Glioblastomas
YouTube video Video | Slides PDF file
David Gutman, M.D., Ph.D.
Emory University
31 Closing
YouTube video Video | Slides PDF file
Elaine Mardis, Ph.D.
Washington University School of Medicine

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Last Reviewed: March 21, 2012


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Comments:

  • Anonymous (December 12, 2011, 16:09)

    Thanks for making all of these resources available.

  • Rao Divi (December 7, 2011, 15:28)

    Disproportionately high C/T transition in heterogeneous tumor tissue is very surprising. The predominant C/T transition observed in TCGA samples may be a sequence specific pre-analytical artifact. If not all, some of them may be systematic pre-analytical artifacts. The artifact may be generated by deaminases or other biomolecules present in nucleus or cytosol that deaminate 5-methylcytosine to thymidine during cell lysis and DNA extraction. For every C/T transition, investigators should try confirming it by sequencing complementary strand. Endogenous mutation will show as G/A transition in opposite strand, whereas the C/T artifact transition shows 'G' opposite T. The high degree of C/T transition may be a function of deaminase levels/activity in vitro. When isolating DNA from human samples, nucleoside deaminase inhibitors, nitric oxide scavengers, and thymine-DNA glycosylase inhibitors may be included in buffers used for cell lysis and DNA extraction to prevent C/T transition artifact. Uracil-DNA glycosylase is included in PCR buffers to prevent C/U transition from thermal deamination during DNA amplification, but inclusion of deaminase inhibitors and TDG-inhibitors in DNA extraction buffers may be equally important to prevent artifacts.

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