Eric D. Green, M.D., Ph.D.

Director, National Human Genome Research Institute

Selected Publications

Green ED and Olson MV: Chromosomal region of the cystic fibrosis gene in yeast artificial chromosomes: a model for human genome mapping. Science, 250:94-98. 1990. [PubMed]

Bouffard GG, Idol JI, Braden VV, Iyer LM, Cunningham AF, Weintraub LA, Touchman JW, Mohr-Tidwell RM, Peluso DC, Fulton RS, Ueltzen MS, Weissenbach J, Magness CL, and Green ED: A physical map of human chromosome 7: an integrated YAC contig map with average STS spacing of 79 kb. Genome Res, 7:673-692. 1997. [PubMed]

Everett LA, Glaser B, Beck JC, Idol JR, Buchs A, Heyman M, Adawi F, Hazani E, Nassir E, Baxevanis AD, Sheffield VC, and Green ED: Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS). Nat Genet, 17:411-422. 1997. [PubMed]

Mouse Genome Sequencing Consortium: Initial sequencing and comparative analysis of the mouse genome. Nature, 420:520-562. 2002. [PubMed]

Mammalian Gene Collection (MGC) Program Team: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci USA, 99:16899-16903. 2002. [PubMed]

Collins FS, Green ED, Guttmacher AE, and Guyer MS: A vision for the future of genomics research: a blueprint for the genomic era. Nature, 422:835-847. 2003. [PubMed]

Antonellis A., Ellsworth R.E., Sambuughin N., Puls I., Abel A., Lee-Lin S-Q., Jordanova A., Kremensky I., Christodoulou K., Middleton L.T., Sivakumar K., Ionasescu V., Funalot B., Vance J.M., Goldfarb L.G., Fischbeck K.H., and Green E.D. Glycyl tRNA synthetade mutations in Charcot-Marie-Tooth Disease type 2D and distal spinal muscular atrophy type V. Am J Hum Genet, 72:1293-1299. 2003. [PubMed]

Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, VanBrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam A-M, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang S-P, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, and Wilson RK: The DNA sequence of human chromosome 7. Nature, 424:157-164. 2003. [PubMed]

Thomas JW, Touchman JW, Blakesley RW, Bouffard GG, Beckstrom-Sternberg SM, Margulies EH, Blanchette M, Siepel AC, Thomas PJ, McDowell JC, Maskeri B, Hansen NF, Schwartz MS, Weber RJ, Kent WJ, Karolchik D, Bruen TC, Bevan R, Cutler DJ, Schwartz S, Elnitski L, Idol JR, Prasad AB, Lee-Lin S-Q, Maduro VVB, Summers TJ, Portnoy ME, Dietrich NL, Akhter N, Ayele K, Benjamin B, Cariaga K, Brinkley CP, Brooks SY, Granite S, Guan X, Gupta J, Haghighi P, Ho S-L, Huang MC, Karlins E, Laric PL, Legaspi R, Lim MJ, Maduro QL, Masiello CA, Mastrian SD, McCloskey JC, Pearson R, Stantripop S, Tiongson EE, Tran JT, Tsurgeon C, Vogt JL, Walker MA, Wetherby KD, Wiggins LS, Young AC, Zhang L-H, Osoegawa K, Zhu B, Zhao B, Shu CL, De Jong PJ, Lawrence CE, Smit AF, Chakravarti A, Haussler C, Green P, Miller W, and Green ED. Comparative analyses of multi-species sequences from targeted genomic regions. Nature, 424:788-793. 2003. [PubMed]

Margulies E.H., Blanchette M., NISC Comparative Sequencing Program, Haussler D., and Green E.D.. Identification and characterization of multi-species conserved sequences. Genome Research, 14:673-678. 2003. [PubMed]

The ENCODE Project Consortium: The ENCODE (ENCyclopedia Of DNA Elements) Project. Science, 306(5696):636-40. 2002. [PubMed]

The MGC Project Team: The status, quality, and expansion of the NIH full-length cDNA project: The Mammalian Gene Collection (MGC). Genome Res, 14:2121-2127. 2004. [PubMed]

Blakesley R.W., Hansen N.F., Mullikin J.C., Thomas P.J., McDowell J.C., Maskeri B., Young A.C., Benjamin B., Brooks S.Y., Coleman B.I., Gupta J., Ho S-L., Karlins E.M., Maduro Q.L., Stantripop S., Tsurgeon C., Vogt J.L., Walker M.A., Masiello C.A., Guan X., NISC Comparative Sequencing Program, Bouffard G.G., Green E.D. An intermediate grade of finished genomic sequence suitable for comparative analyses. Genome Research, 14:2235-2244. 2004. [PubMed]

Margulies EH, NISC Comparative Sequencing Program, Maduro VVB, Thomas PJ, Tomkins JP, Amemiya CT, Luo M, and Green ED: Comparative sequencing provides insights about the structure and conservation of marsupial and monotreme genomes. Proc Natl Acad Sci USA, 102:3354-3359. 2005. [PubMed]

Schueler, M.G., Dunn, J.M., Bird, C.P., Ross, M.T., Viggiano, L., NISC Comparative Sequencing Program, Rocchi, M., Willard, H.F., and Green, E.D. Progressive proximal expansion of the primate X chromosome centromere. Proc Natl Acad Sci USA. 102:10563-10568. 2005. [PubMed]

Hurle B, Swanson W, NISC Comparative Sequencing Program, and Green ED: Comparative sequence analyses reveal rapid and divergent evolutionary changes of the WFDC locus in the primate lineage. Genome Res, 17:276-286. 2007. [PubMed]

The ENCODE Project Consortium: Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature, 447:799-816. 2007. [PubMed]

Margulies EH, Cooper GM, Asimenos G, Thomas DJ, Dewey CN, Siepel A, Birney E, Keefe D, Schwartz AS, Hou M, Taylor J, Nikolaev S, Montoya-Burgos JI, Loytynoja A, Whelen S, Pardi F, Massingham T, Brown JB, Bickel P, Holmes I, Mullikin JC, Ureta-Vidal A, Paten B, Stone EA, Rosenbloom KR, Kent WJ, NISC Comparative Sequencing Program, Bayor College of Medicine Human Genome Sequencing Center, Washington University Genome Sequencing Center, Broad Institute, UCSC Genome Brower Team, British Columbia Cancer Agency Genome Sciences Center, Antonarakis SE, Batzoglou S, Goldman N, Hardison R, Haussler D, Miller W, Pachter L, Green ED, and Sidow A: Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome. Genome Res, 17:760-774. 2007. [PubMed]

Prasad AB, Allard MW, NISC Comparative Sequencing Program, Green ED. Confirming the phylogeny of mammals by use of large comparative sequence data sets. Mol Biol Evol, 25:1795-1808. 2008. [PubMed]

Tsipouri V, Schueler MG, Hu S, NISC Comparative Sequencing Program, Dutra A, Pak E, Riethman H, Green ED. Comparative sequence analyses reveal sites of ancestral chromosomal fusions in the Indian muntjac genome. Genome Biol, 9:R155. 2008. [PubMed]

Dennis MY, Paracchini S, Scerri TS, Prokunina-Olsson L, Knight JC, Wade-Martins R, Coggill P, Beck S, Green ED, Monaco AP. A common variant associated with dyslexia reduces expression of the KIAA0319 gene. PLoS Genet, 5:e1000436. 2009. [PubMed]

Biesecker LG, Mullikin JC, Facio FM, Turner C, Cherukuri PF, Blakesley RW, Bouffard GG, Chines PS, Cruz P, Green ED. The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. Genome Res, 19:1665-1674. 2009. [PubMed]

Toronto International Data Release Workshop Authors: Prepublication data sharing. Nature, 461:168-170. 2009. [PubMed]

MGC Project Team: The completion of the Mammalian Gene Collection (MGC). Genome Res, 19:2324-2333. 2009. [PubMed]

Genome 10K Community of Scientists: Genome 10K: a proposal to obtain whole-genome sequence for 10,000 vertebrate species. J Hered, 100:659-674. 2009. [PubMed]

Blakesley RW, Hansen NF, Gupta J, McDowell JC, Maskeri B, Barnabas BB, Brooks SY, Coleman H, Haghighi P, Ho S-L, Schandler K, Stantripop S, Vogt JL, Thomas PJ, NISC Comparative Sequencing Program, Bouffard GG, and Green ED: Effort required to finish shotgun-generated genome sequences differs significantly among vertebrates. BMC Genomics, 11:21. 2010. [PubMed]

Schueler MG, Swanson W, Thomas PJ, NISC Comparative Sequencing Program, and Green ED: Adaptive evolution of foundation kinetochore proteins in primates. Mol Biol Evol, 27:1585-1597. 2010. [PubMed]

Chodroff RA, Goodstadt L, Sirey TM, Oliver PL, Davies KE, Green ED, Molnár Z, and Ponting CP: Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes. Genome Biol, 11:R72. 2010. [PubMed]

Andres AM, Dennis MY, Kretzschmar WW, Cannons JL, Lee-Lin S-Q, Hurle B, NISC Comparative Sequencing Program, Schwartzberg PL, Williamson SH, Bustamante CD, Nielsen R, Clark AG, and Green ED: Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLoS Genet, 6:e1001157. 2010. [PubMed]

The 1000 Genomes Project Consortium: A map of human genome variation from population-scale sequencing. Nature, 467:1061-1073. 2010. [PubMed]

Hurle B, Marques-Bonet T, Antonacci F, Hughes I, Ryan JF, NISC Comparative Sequencing Program, Eichler EE, Ornitz DM, and Green ED: Lineage-specific evolution of the vertebrate Otopetrin gene family revealed by comparative genomic analyses. BMC Evol Biol, 11:23. 2011. [PubMed]

Green ED, Guyer MS, and National Human Genome Research Institute: Charting a course for genomic medicine from base pairs to bedside. Nature, 470:204-213. 2011. [PubMed]

The ENCODE Project Consortium: A user's guide to the Encyclopedia of DNA Elements (ENCODE). PLoS Biol, 9:e1001046. 2011. [PubMed]

Feero WG and Green ED: Genomics education for health care professionals in the 21st century. JAMA, 306(9):989-90. 2011. [PubMed]

Manolio TA and Green ED: Genomics reaches the clinic: from basic discoveries to clinical impact. Cell, 147:14-16. 2011. [PubMed]

Lindblad-Toh K, Garber M, Zuk O, Lin MF, Parker BJ, Washietl S, Kheradpour P, Ernst J, Jordan G, Mauceli E, Ward LD, Lowe CB, Holloway AK, Clamp M, Gnerre S, Alföldi J, Beal K, Chang J, Clawson H, Cuff J, Di Palma F, Fitzgerald S, Flicek P, Guttman M, Hubisz MJ, Jaffe DB, Jungreis I, Kent WJ, Kostka D, Lara M, Martins AL, Massingham T, Moltke I, Raney BJ, Rasmussen MD, Robinson J, Stark A, Vilella AJ, Wen J, Xie X, Zody MC, Broad Institute Sequencing Platform and Whole Genome Assembly Team, Baldwin J, Bloom T, Chin CW, Heiman D, Nicol R, Nusbaum C, Young S, Wilkinson J, Worley KC, Kovar CL, Muzny DM, Gibbs RA, Baylor College of Medicine Human Genome Sequencing Center Sequencing Team, Cree A, Dihn HH, Fowler G, Jhangiani S, Joshi V, Lee S, Lewis LR, Nazareth LV, Okwuonu G, Santibanez J, Warren WC, Mardis ER, Weinstock GM, Wilson RK, Genome Institute at Washington University, Delehaunty K, Dooling D, Fronik C, Fulton L, Fulton B, Graves T, Minx P, Sodergren E, Birney E, Margulies EH, Herrero J, Green ED, Haussler D, Siepel A, Goldman N, Pollard KS, Pedersen JS, Lander ES, and Kellis M: A high-resolution map of human evolutionary constraint using 29 mammals. Nature, 478:476-482. 2011. [PubMed]

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Last Updated: November 17, 2011