Cell

7 December, 2012
Volume 151, Issue 6

Volume 151, Issue 6

On the cover: In its natural environment, Drosophila melanogaster feeds on yeasts that grow on sugar-rich substrates such as fermenting fruit. Fruits, however, also harbor toxic microbes, and flies need to distinguish those microbes that are safe and nutritious from the harmful ones. In this issue, Stensmyr et al. (pp. 1345–1357) demonstrate that flies detect toxic molds by sensing a volatile compound called geosmin, which exclusively triggers a dedicated signaling pathway in the flies' olfactory system. This circuit, upon activation, causes innate aversion and also prevents egg laying and feeding. Cover concept by Rakel and Marcus Stensmyr. Clay modeling and photo by Marcus Stensmyr.

Announcement

Cell Press has been chosen by the International Society for Stem Cell Research (ISSCR) to publish its new open access journal Stem Cell Reports, which will launch in June 2013.
Find out more.

» Microbiome and host health
» Mitochondria
» Genes, circuits, and behavior
» Immunometabolism
» Cancer epigenomics
» Human evolution
» Stem cells for modeling and treating disease
Click here to find out about these topics and our Cell Symposia series.

Coming December 21st

» Mutational hot spots in human genome
» Focal adhesions in durotaxis
» Reprogramming refractory cells

Review Issue: Human Disease

Editorial Openings

Most-Read Papers

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New!

Cell 2011 Impact Factor: 32.403
Source: © Thomson Reuters Journal Citation Reports (2012)

In this show, Parasites and Vectors, get a close up view of these organisms that cause or transmit diseases such as malaria.

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Cell Press celebrates the achievements of Cell and Cell Stem Cell Editorial Board member Shinya Yamanaka and Sir John B. Gurdon, the recipients of the 2012 Nobel Prize in Physiology or Medicine.

Read the award winners' research published in Cell Press journals FREE including Dr. Yamanaka's groundbreaking 2006 paper in Cell: "Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors".

Interviews
Videos
SnapShots

Aggregation of Olfactory Genes

Stavros Lomvardas reveals how monogenic expression of olfactory receptors works.

Predicting Therapeutic Index

Tony Letai suggests BH3 peptides could help optimize treatment for leukemia patients.

Lymph Node Battleground

Ron Germain on how the geography of the lymph node helps block the dissemination of pathogens.

Listen to more PaperClips.

Structure of the Rod Sensory Cilium
Wensel and colleagues
November 21, 2012

Topography of the Barrier to Transcription
Bustamante and colleagues
November 9, 2012

Membrane Shapes Fission
Roux and colleagues
October 26, 2012

View more PaperFlicks.

Telomeres and Telomerase
Andrea J. Berman and Thomas R. Cech

Cortical Development
Mollie B. Woodworth, Luciano Custo Greig, Arnold R. Kriegstein, and Jeffrey D. Macklis

Bone Metastasis
Brian Ell and Yibin Kang

View all of our SnapShots.

Introducing the new SnapShot archive: With >120 SnapShots—sorted and categorized—from chromatin remodelers and autophagy to cancer and autism.
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SnapShot

SnapShots present up-to-date tables of nomenclature and glossaries, full signaling pathways, and schematic diagrams of cellular processes. See the full list of SnapShots.

mTORC1 Signaling at the Lysosomal Surface
Liron Bar-Peled and David M. Sabatini

http://qc.download.cell.com/pdf/PIIS0092867412014237.pdf

NEW! Spotlight on China:
Informational Supplement to Immunity

Cell Press is proud to bring you Spotlight on China. This informational supplement captures the ongoing progress in immunology research in China.

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Free access made possible by: The Chinese Society for Immunology, CNBG, GlaxoSmithKline, Sino Biological, Inc.

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Guide to Publishing with Cell Press

Watch four Cell Press editors answer questions from three early-career scientists about preparing, submitting, and publishing an article in a Cell Press journal.

Issue Highlights

SPECIAL FOCUS

Organelles as Signaling Platforms

A special focus in Leading Edge on the roles played by organelles as platforms for signaling pathways from innate immunity to growth and metabolism.

Perspectives from Kagan on endosomes and innate immune signaling and Brodsky on ER-associated degradation. Review by Andrews et al. on Bcl2 signaling at the mitochondria. SnapShot by Bar-Peled and Sabatini on mTORC1 activity at the lysosomal surface.

BENCHMARKS

Nobel Prize Celebrations

As the awards ceremony for the 2012 Nobel Prizes approaches, we take a closer look at the discoveries celebrated in this year's awards for GPCR structures and cellular reprogramming.

Essay by Benovic

Essay by Daley

Annotated Classic by Hochedlinger

BOOK REVIEW

Helix Revisited

Cell Press President Lynne Herndon reviews the new edition of The Double Helix by Jim Watson, now annotated and illustrated by Alexander Gann and Jan Witkowski.

Book Review by Lynne Herndon

RESEARCH

Cancer Metabolism

The loss of SIRT6 promotes the metabolic reprogramming of cancer cells by increasing aerobic glycolysis and ribosome biosynthesis.

Article by Mostoslavsky et al.

Preview by Cantley

Cell PaperFlick

PaperFlicks A Conserved Dedicated Olfactory Circuit for Detecting Harmful Microbes in Drosophila
Marcus Stensmyr and colleagues explain how they discovered a brain circuit that signals disgust to rotten food in fruit flies, helping the flies to sniff out and avoid harmful environments.

Featured Article free

Springing a Leak in the Blood Brain Barrier
Jeremy Nathans describes the work of his lab to characterize the function of Norrin, a Wnt ligand, in maintaining the blood brain barrier in epithelial cells of the retina.

In this issue's interview, Jeremy provides the historical context for the Norrin field, going back to work in the 1920s from a Danish ophthalmologist. Whether this work could lead to new ways to modulate the plasticity of the blood brain barrier is an open question.

This PaperClip features the musical theme, "the phoenix - 1st sonata for helena in style of 303" (the phoenix) / CC BY 3.0.

Have 5 minutes to learn about cutting-edge research in Cell? Browse our PaperClip archive.

Leading Edge Featured Article free

Looking Back at the Original Yamanaka Paper
In the first of an occasional series of Cell Annotated Classics, Konrad Hochedlinger makes notes in the margins of the original iPS paper from Nobel Prize winner Shinya Yamanaka, published in Cell in 2006. Konrad comments on his first impressions of the paper and how the field has moved on since then as a result of this groundbreaking study.

Annotated Classic: The iPS Breakthrough Paper
Konrad Hochedlinger

Cell Podcast

Podcast From Preserving Fertility to Understanding Metastasis
November 2012

In this month's Cell Podcast, we learn:

» How stem cells from the testes may preserve fertility in young male cancer patients, with Kyle Orwig (0:00) (Cell Stem Cell)
» About the crucial role of TGF-ß in the spread of colorectal cancer, with Eduard Batlle (8:30) (Cancer Cell)
» Plus, sample a selection of the hottest new papers from Cell Press (15:15)

Music for the podcast includes "TinyJazz" (axjack) / CC BY 3.0.

You can listen directly by clicking on the player above. For a complete list of Cell Press podcasts, you can subscribe via iTunes or view the archive.

Cell PaperClip from November 9th

Nuclear Aggregation of Olfactory Receptor Genes Governs Their Monogenic Expression
Stavros Lomvardas reveals that monogenic expression of olfactory receptors (ORs) in olfactory sensory neurons requires the aggregation of silent OR alleles into heterochromatic foci.

In this issue's interview, Stavros describes how his group discovered that disruption of these foci via ectopic expression of the lamin b receptor leads to the coexpression of multiple OR alleles.