Director's Corner

Legislative Information

Scientific Publications

| Review Articles | Original Publications | Book Chapters |

Review Articles

Anderson LM, Gibbons GH. Notch: a mastermind of vascular morphogenesis. J Clin Invest. 2007; 117(2):299-302.
Gibbons GH. Physiology, genetics, and cardiovascular disease: focus on African Americans. J Clin Hypertens (Greenwich). 2004; 6(4 Suppl 1):11-8.
Gibbons GH, Liew CC, Goodarzi MO, Rotter JI, Hsueh WA, Siragy HM, Pratt R, Dzau VJ. Genetic markers: progress and potential for cardiovascular disease. Circulation. 2004; 109(25 Suppl 1):IV47-58.
Gibbons GH, Pollman MJ. Death receptors, intimal disease, and gene therapy: are therapies that modify cell fate moving too Fas? Circ Res. 2000; 86(10):1009-12.
Gibbons GH. The pathophysiology of hypertension: the importance of angiotensin II in cardiovascular remodeling. Am J Hypertens. 1998; 11(11 Pt 2):177S-181S.
Dzau VJ, Gibbons GH, Mann M, Braun-Dullaeus R. Future horizons in cardiovascular molecular therapeutics. Am J Cardiol. 1997; 80(9A):33I-39I.
Gibbons GH. Cardioprotective mechanisms of ACE inhibition. The angiotensin II-nitric oxide balance. Drugs. 1997;54 Suppl 5:1-11.
Gibbons GH. Endothelial function as a determinant of vascular function and structure: a new therapeutic target. Am J Cardiol. 1997; 79(5A):3-8. Review.
Gibbons GH. Vasculoprotective and cardioprotective mechanisms of angiotensin-converting enzyme inhibition: the homeostatic balance between angiotensin II and nitric oxide. Clin Cardiol. 1997; 20(11 Suppl 2): II-18-25.
Gibbons GH, Dzau VJ. Molecular therapies for vascular diseases. Science. 1996; 272(5262):689-93.
Dzau VJ, Gibbons GH, Kobilka BK, Lawn RM, Pratt RE. Genetic models of human vascular disease. Circulation. 1995; 91(2):521-31.
Gibbons GH. Vascular remodeling in hypertension: role of autocrine-paracrine factors. Blood Press Suppl. 1995; 2:49-54
Gibbons GH. Mechanisms of vascular remodeling in hypertension: role of autocrine-paracrine vasoactive factors. Curr Opin Nephrol Hypertens. 1995; 4(2):189-96.
Gibbons GH. The pathogenesis of graft vascular disease: implications of vascular remodeling. J Heart Lung Transplant.1995; 14(6 Pt 2):S149-58.
Morishita R, Gibbons GH, Dzau VJ. Potential for transcatheter application of antisense oligonucleotides for the treatment of vascular diseases. J Interv Cardiol. 1995; 8(4):377-81.
Dzau VJ, Pratt R, Gibbons GH. Angiotensin as local modulating factor in ventricular dysfunction and failure due to coronary artery disease. Drugs. 1994; 47 Suppl 4:1-13.
Dzau VJ, Gibbons GH, Morishita R, Pratt RE. New perspectives in hypertension research. Potentials of vascular biology. Hypertension. 1994; 23(6 Pt 2):1132-40.
Gibbons GH, Dzau VJ. The emerging concept of vascular remodeling. N Engl J Med. 1994; 330(20):1431-8.
Ma AO, Gibbons GH. New insights on renovascular hypertension. Curr Opin Cardiol. 1994 Sep; 9(5):598-605.
Dzau VJ, Gibbons GH. Vascular remodeling: mechanisms and implications. J Cardiovasc Pharmacol. 1993; 21 Suppl 1:S1-5.
Dzau VJ, Gibbons GH, Cooke JP, Omoigui N. Vascular biology and medicine in the 1990s: scope, concepts, potentials, and perspectives. Circulation. 1993; 87(3):705-19.
Dzau VJ, Morishita R, Gibbons GH. Gene therapy for cardiovascular disease. Trends Biotechnol. 1993; 11(5):205-10.
Gibbons GH. Autocrine-paracrine factors and vascular remodeling in hypertension. Curr Opin Nephrol Hypertens. 1993; 2(2):291-8.
Lee PC, Gibbons GH, Dzau VJ. Cellular and molecular mechanisms of coronary artery restenosis. Coron Artery Dis. 1993; 4(3):254-9.
Gibbons GH. Preventive treatment of graft coronary vascular disease: the potential role of vasodilator therapy. J Heart Lung Transplant. 1992; 11(3 Pt 2):S22-7.
Dzau VJ, Gibbons GH, Pratt RE. Molecular mechanisms of vascular renin-angiotensin system in myointimal hyperplasia. Hypertension. 1991; 18(4 Suppl):II100-5.
Dzau VJ, Gibbons GH. Endothelium and growth factors in vascular remodeling of hypertension. Hypertension. 1991; 18(5 Suppl):III115-21.
Gibbons GH. Angiotensin-converting enzyme inhibition and vascular structure in hypertension. J Cardiovasc Pharmacol. 1991; 18 Suppl 7:S19-24.
Gibbons GH, Dzau VJ. Angiotensin converting enzyme inhibition and vascular hypertrophy in hypertension. Cardiovasc Drugs Ther. 1990; 4(1):237-42.
Dzau VJ, Gibbons GH. Cell biology of vascular hypertrophy in systemic hypertension. Am J Cardiol. 1988; 62(11):30G-35G.
Nabel EG, Gibbons GH, Dzau VJ. Pathophysiology of experimental renovascular hypertension. Am J Kidney Dis. 1985; 5(4):A111-9.
Gibbons GH, Dzau VJ, Farhi ER, Barger AC. Interaction of signals influencing renin release. Annu Rev Physiol. 1984; 46:291-308.
Dzau VJ, Gibbons GH, Levin DC. Renovascular hypertension: an update on pathophysiology, diagnosis and treatment. Am J Nephrol. 1983;3(2-3):172-84.

Original Publications

Morris AA, Zhao L, Patel RS, Jones DP, Ahmed Y, Stoyanova N, Gibbons GH, Vaccarino V, Din-Dzietham R, Quyyumi AA. Differences in systemic oxidative stress based on race and the metabolic syndrome: The Morehouse and Emory team up to eliminate health disparities (META-Health) study. Metab Syndr Relat Disord. 2012. [Epub ahead of print].
Morris AA, Ahmed Y, Stoyanova N, Hooper WC, De Staerke C, Gibbons GH, Quyyumi A, Vaccarino V. The association between depression and leptin is mediated by adiposity. Psychosom Med. 2012; 74(5):483-8.
Ofori-Acquah SF, Buchanan ID, Osunkwo I, Manlove-Simmons J, Lawal F, Quarshie A, Quyyumi AA, Gibbons GH, Gee BE. Elevated circulating angiogenic progenitors and white blood cells are associated with hypoxia-inducible angiogenic growth factors in children with sickle cell disease. Anemia. 2012; 2012:156598.
Patel RS, Morris AA, Ahmed Y, Kavtaradze N, Sher S, Su S, Zafari AM, Din-Dzietham R, Waddy SP, Vaccarino V, Alexander RW, Gibbons GH, Quyyumi AA. A genetic risk variant for myocardial infarction on chromosome 6p24 is associated with impaired central hemodynamic indexes. Am J Hypertens. 2012; 25(7):797-803.
Morris AA, Zhao L, Ahmed Y, Stoyanova N, De Staercke C, Hooper WC, Gibbons GH, Din-Dzietham R, Quyyumi A, Vaccarino V. Association between depression and inflammation--differences by race and sex: the META-Health study. Psychosom Med. 2011; 73(6):462-8.
Bidulescu A, Liu J, Musani SK, Fox ER, Samdarshi TE, Sarpong DF, Vaccarino V, Wilson PW, Arnett DK, Din-Dzietham R, Taylor HA, Gibbons GH. Association of adiponectin with left ventricular mass in African Americans: The Jackson Heart Study. Circulation Heart Fail. 2011.
Hendley Y, Zhao L, Coverson DL, Din-Dzietham R, Morris A, Quyyumi AA, Gibbons GH, Vaccarino V. Differences in weight perception among blacks and whites. J Womens Health (Larchmt). 2011; 20(12):1805-11.
Zhao X, Zhang Y, Li L, Mann D, Imig JD, Emmett N, Gibbons GH, Jin LM. Glomerular expression of kidney injury molecule-1 and podocytopenia in diabetic glomerulopathy. Am J Nephrol. 2011; 34(3):268-280.
Bidulescu A, Din-Dzietham R, Coverson DL, Chen Z, Meng YX, Buxbaum SG, Gibbons GH, Welch VL. Interaction of sleep quality and psychosocial stress on obesity in African Americans: the cardiovascular health epidemiology study (CHES). BMC Public Health. 2010; 10:581.
Pan Q, Meng YX, Gibbons GH, Strayhorn G. Effectiveness of an intervention to improve the documentation required for diagnosis of metabolic syndrome in clinics serving African-American patients. Qual Prim Care. 2009; 17(3):191-6.
Allocco DJ, Song Q, Gibbons GH, Ramoni MF, Kohane IS. Geography and genography: prediction of continental origin using randomly selected single nucleotide polymorphisms. BMC Genomics. 2007; 8:68.
Clement CM, Thomas LK, Mou Y, Croslan DR, Gibbons GH, Ford BD. Neuregulin-1 attenuates neointimal formation following vascular injury and inhibits the proliferation of vascular smooth muscle cells. J Vasc Res. 2007;44(4):303-12
Meng YX, Ford ES, Li C, Quarshie A, Al-Mahmoud AM, Giles W, Gibbons GH, Strayhorn G. Association of C-reactive protein with surrogate measures of insulin resistance among nondiabetic US from National Health and Nutrition Examination Survey 1999-2002. Clin Chem. 2007; 53(12):2152-9
Song Q, Cole JW, O'Connell JR, Stine OC, Gallagher M, Giles WH, Mitchell BD, Wozniak MA, Stern BJ, Sorkin JD, McArdle PF, Naj AC, Xu Q, Gibbons GH, Kittner SJ. Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: the stroke prevention in young women study. Hum Mol Genet. 2006; 15(16):2468-78
Zhang J, Zhong W, Cui T, Yang M, Hu X, Xu K, Xie C, Xue C, Gibbons GH, Liu C, Li L, Chen YE. Generation of an adult smooth muscle cell-targeted Cre recombinase mouse model. Arterioscler Thromb Vasc Biol. 2006; 26(3):e23-4.
Xiong C, Tang DQ, Xie CQ, Zhang L, Xu KF, Thompson WE, Chou W, Gibbons GH, Chang LJ, Yang LJ, Chen YE. Genetic engineering of human embryonic stem cells with lentiviral vectors. Stem Cells Dev. 2005; 14(4):367-77.
Igho-Pemu P, Quarshie A, Oduwole A, Lapu-Bula R, Mayberry R, Obialo C, Gibbons GH, Ofili E. Morehouse Community Physicians Network (CPN) hypertension registry: patterns of care and opportunities for targeted medical education. Ethn Dis. 2005; 15(4 Suppl 5):S5-120-3.
Campos AH, Zhao Y, Pollman MJ, Gibbons GH. DNA microarray profiling to identify angiotensin-responsive genes in vascular smooth muscle cells: potential mediators of vascular disease. Circ Res. 2003; 92(1):111-8.
Davis, S. K., Y. Liu, Gibbons. GH. Disparities in trends of hospitalization for potentially preventable chronic conditions among African Americans during the 1990s: implications and benchmarks. Am J Public Health. 2003; 93(3): 447–455.
Campos, A. H., W. Wang, Gibbons, GH. Determinants of Notch-3 receptor expression and signaling in vascular smooth muscle cells: implications in cell-cycle regulation. Circ Res. 2002; 91(11):999-1006.
Hall JL, Gibbons GH, Chatham JC. IGF-I promotes a shift in metabolic flux in vascular smooth muscle cells. Am J Physiol Endocrinol Metab. 2002; 283(3):E465-71.
Morishita R, Gibbons GH, Kaneda Y, Zhang L, Ogihara T, Dzau VJ. Apolipoprotein E-deficient mice created by systemic administration of antisense oligodeoxynucleotides: a new model for lipoprotein metabolism studies. J Endocrinol. 2002; 175(2):475-85.
Hall JL, Wang X, Van Adamson, Zhao Y, Gibbons GH. Overexpression of Ref-1 inhibits hypoxia and tumor necrosis factor-induced endothelial cell apoptosis through nuclear factor-kappab-independent and -dependent pathways. Circ Res. 2001; 88(12):1247-53.
Hall, J. L., J. C. Chatham, Gibbons. GH. Upregulation of glucose metabolism during intimal lesion formation is coupled to the inhibition of vascular smooth muscle cell apoptosis. Role of GSK3beta. Diabetes. 2001; 50(5):1171-9.
Hall, J. L., C. M. Matter,Gibbons, GH. Hyperglycemia inhibits vascular smooth muscle cell apoptosis through a protein kinase C-dependent pathway. Circ Res. 2000; 87(7):574-80.
Morishita R, Gibbons GH, Kaneda Y, Ogihara T, Dzau VJ. Systemic administration of HVJ viral coat-liposome complex containing human insulin vector decreases glucose level in diabetic mouse: A model of gene therapy. Biochem Biophys Res Commun. 2000; 273(2):666-74.
Tomita N, Morishita R, Tomita S, Gibbons GH, Zhang L, Horiuchi M, Kaneda Y, Higaki J, Ogihara T, Dzau VJ. Transcription factor decoy for NFkappaB inhibits TNF-alpha-induced cytokine and adhesion molecule expression in vivo. Gene Ther. 2000; 7(15):1326-32.
Mann MJ, Gibbons GH, Hutchinson H, Poston RS, Hoyt EG, Robbins RC, Dzau VJ. Pressure-mediated oligonucleotide transfection of rat and human cardiovascular tissues. Proc Natl Acad Sci USA. 1999; 96(11): 6411–6416.
Pollman MJ, Naumovski L, Gibbons GH. Endothelial cell apoptosis in capillary network remodeling. J Cell Physiol. 1999; 178(3):359-70.
Pollman MJ, Naumovski L, Gibbons GH. Vascular cell apoptosis: cell type-specific modulation by transforming growth factor-beta1 in endothelial cells versus smooth muscle cells. Circulation. 1999; 99(15):2019-26.
Wang BY, Ho HK, Lin PS, Schwarzacher SP, Pollman MJ, Gibbons GH, Tsao PS, Cooke JP. Regression of atherosclerosis: role of nitric oxide and apoptosis. Circulation. 1999; 99(9):1236-41.
Morishita R, Gibbons GH, Horiuchi M, Kaneda Y, Ogihara T, Dzau VJ. Role of AP-1 complex in angiotensin II-mediated transforming growth factor-beta expression and growth of smooth muscle cells: using decoy approach against AP-1 binding site. Biochem Biophys Res Commun. 1998; 243(2):361-7.
Pollman, M. J., J. L. Hall, Gibbons, GH. Inhibition of neointimal cell bcl-x expression induces apoptosis and regression of vascular disease. Nat Med. 1998; 4(2):222-7.
Tomita N, Horiuchi M, Tomita S, Gibbons GH, Kim JY, Baran D, Dzau VJ. An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro. Am J Physiol. 1998; 275(2 Pt 2):F278-84.
Mann MJ, Gibbons GH, Tsao PS, von der Leyen HE, Cooke JP, Buitrago R, Kernoff R, Dzau VJ. Cell cycle inhibition preserves endothelial function in genetically engineered rabbit vein grafts. J Clin Invest. 1997; 99(6): 1295–1301.
Diet F, Pratt RE, Berry GJ, Momose N, Gibbons GH, Dzau VJ. Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease. Circulation. 1996; 94(11):2756-67.
Ellison KE, Bishopric NH, Webster KA, Morishita R, Gibbons GH, Kaneda Y, Sato B, Dzau VJ. Fusigenic liposome-mediated DNA transfer into cardiac myocytes. J Mol Cell Cardiol. 1996; 28(7):1385-99.
Pollman MJ, Yamada T, Horiuchi M, Gibbons GH. Vasoactive substances regulate vascular smooth muscle cell apoptosis. Countervailing influences of nitric oxide and angiotensin II. Circ Res. 1996; 79(4):748-56.
Tirdel, G. B., Gibbons, GH. Pneumonia with an enlarged cardiac silhouette. Chest. 1996; 109(5):1380-2.
Mann MJ, Gibbons GH, Kernoff RS, Diet FP, Tsao PS, Cooke JP, Kaneda Y, Dzau VJ. Genetic engineering of vein grafts resistant to atherosclerosis. Proc Natl Acad Sci USA. 1995; 92(10): 4502–4506.
Morishita R, Gibbons GH, Horiuchi M, Ellison KE, Nakama M, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. Proc Natl Acad Sci USA. 1995; 92(13):5855-9.
Ohno, M., J. P. Cooke, Gibbons, GH. Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade. J Clin Invest. 1995; 95(3):1363-9.
von der Leyen HE, Gibbons GH, Morishita R, Lewis NP, Zhang L, Nakajima M, Kaneda Y, Cooke JP, Dzau VJ. Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci USA. 1995; 92(4):1137-41.
Morishita R, Gibbons GH, Kaneda Y, Ogihara T, Dzau V. Pharmacokinetics of antisense oligodeoxyribonucleotides (cyclin B1 and CDC 2 kinase) in the vessel wall in vivo: enhanced therapeutic utility for restenosis by HVJ-liposome delivery. Gene.1994; 149(1):13-9.
Morishita R, Gibbons GH, Pratt RE, Tomita N, Kaneda Y, Ogihara T, Dzau VJ. Autocrine and paracrine effects of atrial natriuretic peptide gene transfer on vascular smooth muscle and endothelial cellular growth. J Clin Invest. 1994; 94(2): 824–829.
Morishita R, Gibbons GH, Ellison KE, Lee W, Zhang L, Yu H, Kaneda Y, Ogihara T, Dzau VJ. Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme. J Clin Invest. 1994; 94(3): 978–984.
Morishita R, Gibbons GH, Ellison KE, Nakajima M, von der Leyen H, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. J Clin Invest. 1994; 93(4):1458-64.
Itoh H, Mukoyama M, Pratt RE, Gibbons GH, Dzau VJ. Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II. J Clin Invest. 1993; 91(5):2268-74.
Koibuchi, Y., W. S. Lee,Gibbons, GH. Role of transforming growth factor-beta 1 in the cellular growth response to angiotensin II. Hypertension. 1993; 21(6 Pt 2):1046-50.
Morishita R, Gibbons GH, Ellison KE, Nakajima M, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc Natl Acad Sci USA. 1993; 90(18): 8474–8478.
Morishita R, Gibbons GH, Kaneda Y, Ogihara T, Dzau VJ. Novel and effective gene transfer technique for study of vascular renin angiotensin system. J Clin Invest. 1993; 91(6):2580-5.
Morishita R, Gibbons GH, Kaneda Y, Ogihara T, Dzau VJ. Novel in vitro gene transfer method for study of local modulators in vascular smooth muscle cells. Hypertension. 1993; 21(6 Pt 2):894-9.
Ohno M, Gibbons GH, Dzau VJ, Cooke JP. Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling. Circulation. 1993; 88(1):193-7.
Gibbons GH, Pratt RE, Dzau VJ. Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II. Journal of Clinical Investigation. 1992; 90(2): 456–461.

Book Chapters

Davis SK, Quarells RC, Gibbons GH. Hypertension in African-American Communities. In Health Issues in the Black Community, ed Ronald Braithwaite, 3rd Edition. San Francisco: Jossey-Bass, 2009.
Gibbons GH, Pfeffer MA. Role of the Renin-Angiotensin-Aldosterone System in Cardiovascular Disease—Pathophysiologic Insights and Therapeutic Implications. IN Atherothrombosis and Coronary Artery Disease. Ed Valentin Fuster, Eric J. Topol, Elizabeth G. Nabel. Lippincott, Williams and Wilkins, 2005.
Gibbons GH, Pollman M. Gene Therapy for Cardiovascular Disease. In Cardiovascular Therapeutics: A Companion to Braunwald’s Heart Disease, ed Elliott M. Antman. Philadelphia: W.B. Saunders, 2002.
Gibbons GH. Pathobiology of Hypertension. Chapter 104 In Textbook of Cardiovascular Medicine ed Eric J. Topol. Philadelphia: Lippincott Williams & Wilkins, 2002.
Gibbons GH. Pathobiology of Hypertension. Chapter 112. In Comprehensive Cardiovascular Medicine Volume 2, ed Eric J. Topol. Philadelphia: Lippincott-Raven, 1998.

Last Updated: October 16, 2012

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