Immunogenicity, immunologic memory, and safety following measles revaccination in HIV-infected children receiving highly active antiretroviral therapy.
Abzug MJ,
Qin M,
Levin MJ,
Fenton T,
Beeler JA,
Bellini WJ,
Audet S,
Sowers SB,
Borkowsky W,
Nachman SA,
Pelton SI,
Rosenblatt HM;
International Maternal Pediatric Adolescent AIDS Clinical Trials Group P1024 and P1061s Protocol Teams.
Jankelevich S, Jean-Philippe P, Read J, Hadhazy V, Robbins A, Sheeran B, Lindsey JC, Song LY, Hodge J, Caporale M, Webb N, Ashton C, Smith D, Angeli L, Pella J, Tran P, Aldrovandi G, Barrett R, Kabat W, Shaw A, Isaacman D, Keeley V, Willems P, Gore C, Yogev R, Dashefsky B, Bettica L, Palumbo P, Abrams E, Frere M, Robinson LG, Bamji M, Deveikis A, Marks S, Elkins K, Melton L, Jimenez E, Homans J, Melendez A, Kovacs A, Rathore MH, Alvarez A, Mirza A, Chiu T, Spector SA, Viani R, Caffery M, Stangl L, Ferraro D, Muniz S, Davi M, Maes J, Salbenblatt C, Paul S, Barr E, Bonagura VR, Schuval SJ, Colter C, Petru A, Courville T, Gold K, Poole L, Chen JS, Foster JA, Conway DH, Koutsoubis G, Regan AM, Moallem H, Handelsman E, Swindell D, Kaye J, Figueroa W, Dummitt M, Kallury A, Purswani M, Bakshi S, Stuard E, Arpadi S, Luzuriaga K, Smith D, Burchett S, Lewis L, Kneut C, Inman A, Tran L, Talero G, Puga A, Farley J, MacFadden M, Wara D, Akleh S, Kaul A, Chandwani S, Hastings T, Weinberg GA, Laverty S, Murante B, Gigliotti F, Andiman WA, Hurst L, Romano S, Rodriguez I, Salazar JC, Karas G, Wells L, Shearer W, Martinez J, Stavola J, Spiegel H, Lawrence R, Van Dyke R, Borne C, Cowie M, Pass R, Crain M, Beatty N.
Source
Pediatric Infectious Diseases, Box B055, Children’s Hospital Colorado, 13123 East 16th Ave, Aurora, CO 80045, USA. mark.abzug@childrenscolorado.org
Abstract
BACKGROUND:
Response rates and immunologic memory following measles vaccination are reduced in human immunodeficiency virus (HIV)-infected children in the absence of highly active antiretroviral therapy (HAART).
METHODS:
HIV-infected children 2 to <19 years old receiving HAART and with HIV loads <30,000 copies/mL, CD4% ≥15, and ≥1 prior measles-mumps-rubella vaccination (MMR) were given another MMR. Measles antibody concentrations before and 8, 32, and 80 weeks postvaccination were determined by plaque reduction neutralization (PRN). A subset was given another MMR 4-5 years later, and PRN antibody was measured before and 7 and 28 days later.
RESULTS:
At entry, 52% of 193 subjects were seroprotected (PRN ≥120 mIU/mL). Seroprotection increased to 89% 8 weeks postvaccination, and remained at 80% 80 weeks postvaccination. Of 65 subjects revaccinated 4-5 years later, 85% demonstrated memory based on seroprotection before or 7 days after vaccination. HIV load ≤400 copies/mL at initial study vaccination was associated with higher seroprotection rates, greater antibody concentrations, and memory. Grade 3 fever or fatigue occurred in 2% of subjects.
CONCLUSIONS:
Measles revaccination induced high rates of seroprotection and memory in children receiving HAART. Both endpoints were associated with HIV viral load suppression. Clinical Trials Registration: NCT00013871 (www.clinicaltrials.gov).
- PMID:
- 22693229
- [PubMed - indexed for MEDLINE]
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