Drug resistant infections beat by natural compound
Researchers have discovered and isolated a naturally occurring compound that is highly effective at eliminating growth of gram positive and gram negative bacteria in vitro.
April 3, 2012
Natural compound provides low-cost therapeutics to treat multi-drug resistant infections.
We believe these natural produces are amenable to cost-effective chemical synthesis methodologies to increase their diversity and to provide low-cost therapeutics to treat multi-drug resistant infections.
Drug resistant infections beat by naturally occurring compound
Applications:
- Effective treatment of drug
resistant pathogens
Benefits:
- Useful against a broad spectrum of bacteria
- Unique structure is amenable
to synthesis
- Unique structure will make
development of resistance difficult
Summary:
A
team of Los Alamos researchers has discovered and isolated a naturally occurring compound that is highly effective at eliminating growth of gram positive
and gram negative bacteria in vitro. The team analyzed the organism that
naturally produces the compound to determine the genetically encoded components
if the enzymatic cluster associated with the biosynthesis of this natural
product. Subsequently, using bioinformatics, this information was used to
interrogate databases of known sequences from other organisms and identify
similar assembly lines that produce structurally similar compounds. The natural
products from these newly identified organisms are structurally different from
any known antibacterials. We believe these natural produces are amenable to
cost-effective chemical synthesis methodologies to increase their diversity and
to provide low-cost therapeutics to treat multi-drug resistant infections.
Development stage: Multiple
organisms that produce these natural products are being cultured to synthesize
adequate quantities of bioactive compounds from each with which to conduct
toxicological and mutagenicity studies in human cell lines.
Intellectual property status: Patent application pending.
Licensing status: Los Alamos is seeking commercial partners
to co-develop the technology.
Related Articles
All StoriesAugust, 6 2012 - Researchers at LANL began working with domestic honeybees in 2006 to detect explosive materials and narcotics.
April, 3 2012 - A revolutionary method of building a membrane electrode assembly (MEA) for PEM fuel cells allows LANL to offer significant cost reductions and performance enhancements necessary for mainstream applications.
April, 3 2012 - LANL’s Digital Knowledge Discovery Team has created a suite of digital-content-analysis tools to gather, reduce, annotate, organize, synthesize, and visualize digital content.
April, 3 2012 - New apparatus that is designed to be inexpensive, reconfigurable, and adaptable to both surface and solution electrochemical experiments.
April, 3 2012 - Energy use and related thermal management issues are serious business concerns, but with EnergyFit LANL can significantly reduce heat output and maintain consistent electrical cost.
April, 3 2012 - This new class of smart coatings are non-odorous but release an odor in the presence of selected gases of concern, reducing contamination and alerting people when danger arises.
April, 3 2012 - Kip is a high-performance ray tracing library that provides rapid rendering and compact code while using very little memory so large numbers of shapes can be used simultaneously.
April, 3 2012 - Through an advanced computational modeling code that accurately simulates the in-cylinder processes of engines, LANL scientists have addressed many costly issues.
April, 3 2012 - New antenna has potential applications in RADAR, secure communications, ultra-long-range communications, oncology and astrophysics.
April, 3 2012 - High-speed cameras becomes less effective at high speeds; MOXIE fixes that problem by simultaneously providing both the highest photographic and physical speeds.