Enrico Cabib, Ph.D.


LBG
MORPHOGENESIS SECTION
NIDDK, National Institutes of Health
Building 8 , Room 310
8 Center Dr.
Bethesda, MD 20814
Tel: 301-496-1008
Fax: 301-402-0240
Email: enricoc@bdg10.niddk.nih.gov

Enrico Cabib, Ph.D.

Education / Previous Training and Experience:
B.S., University of Buenos Aires, Argentina, 1949
Ph.D., University of Buenos Aires, Argentina, 1951


Research Statement:
The Section studies morphogenesis using as models two structures of the yeast, Saccharomyces cerevisiae: the cell wall, which imparts shape to the cell, and the primary septum, a disc that is laid down at cytokinesis to separate mother and daughter cells. Beta(1-3)glucan and chitin are the main structural components of the cell wall and septum, respectively. The biosynthesis of these polysaccharides and its regulation is studied with the tools of enzymology, molecular biology, genetics, and cytology, including immunofluorescence. The architecture of the cell wall, including the cross-linking of its components, is another aspect of the research carried out in the Section.


Selected Publications:

1. Cabib E, Duran A Synthase III-dependent chitin is bound to different acceptors depending on location on the cell wall of budding yeast. J Biol Chem(280): 9170-9, 2005. [Full Text/Abstract]

2. Cabib E The septation apparatus, a chitin-requiring machine in budding yeast. Arch Biochem Biophys (426): 201-7, 2004. [Full Text/Abstract]

3. Schmidt M Varma A Drgon T Bowers B Cabib E Septins, under Cla4p regulation, and the chitin ring are required for neck integrity in budding yeast. Mol Biol Cell (14): 2128-41, 2003. [Full Text/Abstract]

4. Schmidt M Bowers B Varma A Roh DH Cabib E In budding yeast, contraction of the actomyosin ring and formation of the primary septum at cytokinesis depend on each other. J Cell Sci (115): 293-302, 2002. [Full Text/Abstract]

5. Roh DH Bowers B Riezman H Cabib E Rho1p mutations specific for regulation of beta(1-->3)glucan synthesis and the order of assembly of the yeast cell wall. Mol Microbiol (44): 1167-83, 2002. [Full Text/Abstract]

6. Roh DH Bowers B Schmidt M Cabib E The septation apparatus, an autonomous system in budding yeast. Mol Biol Cell (13): 2747-59, 2002. [Full Text/Abstract]

7. Cabib E Roh DH Schmidt M Crotti LB Varma A The yeast cell wall and septum as paradigms of cell growth and morphogenesis. J Biol Chem (276): 19679-82, 2001. [Full Text/Abstract]

8. Kollar R Reinhold BB Petrakova E Yeh HJ Ashwell G Drgonova J Kapteyn JC Klis FM Cabib E Architecture of the yeast cell wall. Beta(1-->6)-glucan interconnects mannoprotein, beta(1-->)3-glucan, and chitin. J Biol Chem (272): 17762-75, 1997. [Full Text/Abstract]

9. Drgonova J Drgon T Tanaka K Kollar R Chen GC Ford RA Chan CS Takai Y Cabib E Rho1p, a yeast protein at the interface between cell polarization and morphogenesis. Science (272): 277-9, 1996. [Full Text/Abstract]

10. Mol PC Park HM Mullins JT Cabib E A GTP-binding protein regulates the activity of (1-->3)-beta-glucan synthase, an enzyme directly involved in yeast cell wall morphogenesis. J Biol Chem (269): 31267-74, 1994. [Full Text/Abstract]

11. Shaw JA Mol PC Bowers B Silverman SJ Valdivieso MH Duran A Cabib E The function of chitin synthases 2 and 3 in the Saccharomyces cerevisiae cell cycle. J Cell Biol (114): 111-23, 1991. [Full Text/Abstract]



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Page last updated: December 15, 2008

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