Kong Y Chen, Ph.D.



HMN ENRGY & BODY WGHT REG CORE
NIDDK, National Institutes of Health
Building 10-CRC , Room 5-3671
10 Center Dr.
Bethesda, MD 20814
Tel: 301-451-1636
Fax: 301-480-4517
Email: chenkong@niddk.nih.gov

Research Website:


Education / Previous Training and Experience:
PhD, Vanderbilt University, 1997
MS Clinical Investigation, Vanderbilt University, 2002


Research Statement:

Dr. Kong Chen is interested in the regulation of human energy balance in healthy and disease conditions.

Dr. Chen has focused in the measurements of energy metabolism using whole-room indirect calorimeters (respiration or metabolic chambers). Such systems can be coupled with movement and physiological sensors to provide a similar-to-free-living environment where a study subject or patient’s energy expenditure, substrate oxidation, physical activities, temperatures, and heart rate are accurately measured in a minute-by-minute basis up to 24 hours. Dr. Chen and his lab are also investigating the physiological regulations of energy metabolism in lean and obese individuals under different invrionmental conditions, as well as improving the technologies for measuring body composition and physical activity.

Some of his current projects include collaborations in the clinical studies which follow.


Selected Publications:
  • Celi FS, Butler PW, Brychta RJ, Linderman JD, Alberobello AT, Smith S, Courville AB, Lai EW, Costello R, Skarulis MC, Casko G, Remaley A, Pacak K, Chen KY. Minimal changes in environmental temperature result in a significant increase in energy expenditure and changes in the hormonal homeostasis in healthy adults. European Journal of Endocrinology, 2010, 163(6):863-72.
  • Tamboli RA, Hossain HA, Marks PA, Eckhauser AW, Rathmacher JA, Phillips SE, Buchowski MS, Chen KY, Abumrad NN. Body Composition and Energy Metabolism Following Roux-en-Y Gastric Bypass Surgery. Obesity (Silver Spring). 2010, 18(9): 1718-24.
  • Rothney MP, Brychta RJ, Meade NN, Chen KY, Buchowski MS. Validation of the ActiGraph Two–Regression Model for Predicting Energy Expenditure. Medicine Science Sports Exercise, 2010 Feb 4. 42(9):1785-92
  • Brychta RJ, Wholer E, Moon J, Chen KY. Measuring Energy Expenditure in Humans. IEEE Eng Med Biol Mag. 2010 Jan/Feb, 42-47.
  • Choi L, Chen KY, Acra S, Buchowski MS. Distributed lag and spline modeling for predicting energy expenditure from accelerometry in youth. Journal of Applied Physiology, 2010 Feb;108(2):314-27.
  • Brychta RJ, Rothney MP, Sakrulis MC, Chen KY. Optimizing Energy Expenditure Detection in Human Metabolic Chambers. Conf Proc IEEE Eng Med Biol Soc 2009:6864-8.
  • Rothney MP, Brychta RJ, Schaefer EV, Chen KY, Skarulis MC. Body composition measured by dual-energy x-ray absorptiometry half-body scans in obese adults. Obesity, 2009, 17:1281–1286.
  • Buchowski MS, Choi L, Majchrzak KM, Acra S, Matthews CE, Chen KY. Seasonal Changes in Amount and Patterns of Physical Activity in Women in the Southeastern United States.  Journal of Physical Activity and Health, 2009; 6:252-261.
  • Dorminy CA, Choi L, Akohoue SA, Chen KY, Buchowski MS. Validity of a multisensor armband in estimating 24-h energy expenditure in children. Medicine Science Sports Exercise, 2008; 40:699-706.
  • Rothney MP, Apker GA, Song Y, Chen KY. Sensor characterization across three generations of ActiGraph accelerometers. Journal of Applied Physiology, 2008, 105:1091-1097.
  • Rothney MP, Schaefer EV, Neumann M, Choi L, Chen KY. Validity of physical activity intensity predictions by ActiGraph, Actical, and RT3 accelerometers. Obesity, 2008; 16: 1946-1952.
  • Matthews CE, Chen KY, Freedson FS, Buchowski MS, Beech BM, Pate RR, Troiano RP. Time spent in sedentary behaviors – United States 2003-2004. American Journal of Epidemiology, 2008; 167:875-881.
  • Shibao C, Gamboa A, Diedrich A, Ertl AC, Chen KY, Byrne DW, Farley G, Paranjape SY, Davis SN, Biaggioni I. Autonomic contribution to blood pressure and metabolism in obesity. Hypertension. 2007; 49:27-33.
  • Akohoue SA, Shankar S, Miline GL. Morrow J, Chen KY, Ajayi WU, Buchowski MS. Energy Expenditure, Inflammation, and Oxidative Stress in Steady-State Adolescents With Sickle Cell Anemia. Pediatric Research. 2007; 61(2):233-238.
  • Rothney MP, Neumann M, Beziat A, Chen KY. An artificial neural network model of energy expenditure using non-integrated acceleration signals. Journal of Applied Physiology 2007; 103(4):1419-27.
  • Huizinga MM, Shintani A, Michon S, Brown A, Wolff K, Shackleford L, King EB, Gregory RP, Davis D, Stiles R, Gebretsadik T, Chen K, Rothman R, Pichert JW, Schlundt D, Elasy TA A randomized controlled trial to prevent glycemic relapse in longitudinal diabetes care: Study protocol (NCT00362193). Implement Sci (1): 24, 2006. [Full Text/Abstract]
  • France DJ, Levin S, Hemphill R, Chen K, Rickard D, Makowski R, Jones I, Aronsky D Emergency physicians'' behaviors and workload in the presence of an electronic whiteboard. Int J Med Inform (74): 827-37, 2005. [Full Text/Abstract]
  • Majchrzak KM, Pupim LB, Chen K, Martin CJ, Gaffney S, Greene JH, Ikizler TA Physical activity patterns in chronic hemodialysis patients: comparison of dialysis and nondialysis days. J Ren Nutr (15): 217-24, 2005. [Full Text/Abstract]
  • Chen KY, Bassett DR Jr The technology of accelerometry-based activity monitors: current and future. Med Sci Sports Exerc (37): S490-500, 2005. [Full Text/Abstract]
  • Flakoll PJ, Kent P, Neyra R, Levenhagen D, Chen KY, Ikizler TA Bioelectrical impedance vs air displacement plethysmography and dual-energy X-ray absorptiometry to determine body composition in patients with end-stage renal disease. JPEN J Parenter Enteral Nutr (28): 13-21, 2004. [Full Text/Abstract]
  • Chen KY, Acra SA, Donahue CL, Sun M, Buchowski MS Efficiency of walking and stepping: relationship to body fatness. Obes Res (12): 982-9, 2004. [Full Text/Abstract]
  • Buchowski MS, Acra S, Majchrzak KM, Sun M, Chen KY Patterns of physical activity in free-living adults in the Southern United States. Eur J Clin Nutr (58): 828-37, 2004. [Full Text/Abstract]
  • Buchholz AC, Majchrzak KM, Chen KY, Shankar SM, Buchowski MS Use of air displacement plethysmography in the determination of percentage of fat mass in african american children. Pediatr Res (56): 47-54, 2004. [Full Text/Abstract]
  • Chen KY, Acra SA, Majchrzak K, Donahue CL, Baker L, Clemens L, Sun M, Buchowski MS Predicting energy expenditure of physical activity using hip- and wrist-worn accelerometers. Diabetes Technol Ther (5): 1023-33, 2003. [Full Text/Abstract]
  • Buchowski MS, Chen KY, Byrne D, Wang WC Equation to estimate resting energy expenditure in adolescents with sickle cell anemia. Am J Clin Nutr (76): 1335-44, 2002. [Full Text/Abstract]
  • Buchowski MS, de la Fuente FA, Flakoll PJ, Chen KY, Turner EA Increased bone turnover is associated with protein and energy metabolism in adolescents with sickle cell anemia. Am J Physiol Endocrinol Metab (280): E518-27, 2001. [Full Text/Abstract]
  • Levenhagen DK, Borel MJ, Welch DC, Piasecki JH, Piasecki DP, Chen KY, Flakoll PJ A comparison of air displacement plethysmography with three other techniques to determine body fat in healthy adults. JPEN J Parenter Enteral Nutr (23): 293-9, 1999. [Full Text/Abstract]
  • Shannon JR, Gottesdiener K, Jordan J, Chen K, Flattery S, Larson PJ, Candelore MR, Gertz B, Robertson D, Sun M Acute effect of ephedrine on 24-h energy balance. Clin Sci (Lond) (96): 483-91, 1999. [Full Text/Abstract]
  • Biaggi RR, Vollman MW, Nies MA, Brener CE, Flakoll PJ, Levenhagen DK, Sun M, Karabulut Z, Chen KY Comparison of air-displacement plethysmography with hydrostatic weighing and bioelectrical impedance analysis for the assessment of body composition in healthy adults. Am J Clin Nutr (69): 898-903, 1999. [Full Text/Abstract]
  • Chen KY, Sun M, Butler MG, Thompson T, Carlson MG Development and validation of a measurement system for assessment of energy expenditure and physical activity in Prader-Willi syndrome. Obes Res (7): 387-94, 1999. [Full Text/Abstract]
  • Buchowski MS, Townsend KM, Chen KY, Acra SA, Sun M Energy expenditure determined by self-reported physical activity is related to body fatness. Obes Res (7): 23-33, 1999. [Full Text/Abstract]
  • Chen KY, Sun M Improving energy expenditure estimation by using a triaxial accelerometer. J Appl Physiol (83): 2112-22, 1997. [Full Text/Abstract]


Clinical Protocols
  • Study of the Phenotype of Overweight and Obese Adults, 07-DK-0077
  • Metabolism and Thyroid Hormone Changes During Exposure to Cold Temperatures, 07-DK-0202
  • Diet-Induced-Obesity Resistant Phenotypes in Humans, 09-DK-0238
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Page last updated: March 09, 2011

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