Immunology Section Images
Intracellular innate immune response to hepatitis C virus. Hepatocytes sense double-stranded RNA (dsRNA) via the cytoplasmic pattern recognition receptor RIG-I and the endosomal pattern recognition receptor TLR3. Secreted IFN-b induces an antiviral state in neighboring uninfected cells via JAK/STAT-mediated signaling. HCV interferes with this pathway at multiple points (for a review see J Clin Invest 119:1745-54).
Adaptive immune responses to HCV and viral escape (for a review see Nature Reviews Immunology 2005; 5: 215-2)
Page last updated: January 20, 2012