Scientific Programs

Robert McKnight

Dr. Robert McKnight was a member of our laboratory from 1989 to 1995. Bob worked on the regulation of the whey acidic protein gene using transgenic mice and pigs. He discovered that matrix attachment regions can shield the WAP gene from postion effects in transgenic mice. Bob received his Ph.D. at UC Davis in Animal Sciences. In 1995 Bob took a position as Assistant Professor at the University of Pittsburgh and then moved to UCLA in 1999. In 2003 Dr. McKnight moved to University of Utah where he is an Assistant Professor in the School of Medicine.
Publications while in LGP

PubMed search

1. McKnight, R.A., Spencer, M., Wall, R.J. and Hennighausen, L. (1996) Severe position effects imposed on a 1 kb mouse whey acidic protein gene promoter are overcome by heterologous matrix attachment regions. Molecular Development and Reproduction 44, 79-184.

2. Wall, R.J., Rexroad, C., Shamay, A., McKnight, R.A. and Hennighausen, L. (1995) Synthesis and secretion of the mouse whey acidic protein in the mammary gland and milk of transgenic sheep. Transgenic Research 5, 67-72.

3. Robinson, G.W., McKnight, R.A., Smith, G.H. and Hennighausen, L. (1995) Mammary epithelial cells undergo differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation. Development 121, 2079-2090.

4. McKnight, R.A., Spencer, M., Dittmer, J., Brady, J., Wall, R.J. and Hennighausen, L. (1995) An Ets site in the whey acidic protein gene promoter mediates transcriptional activation in the mammary gland during pregnancy, but is dispensible during lactation. Mol. Endocrinolgy 9, 717 724.

5. McKnight, R.A., Wall, R.J. and Hennighausen, L. (1995) Expression of genomic and cDNA transgenes after co-integration in transgenic mice. Transgenic Research 4, 39-43.

6. Paleyanda, R.K., Zhang, D.-W., Hennighausen, L., McKnight, R.A. and Lubon, H. (1994) Regulation of human protein C gene expression by the mouse WAP gene promoter. Transgenic Research 3, 335-343.

7. Hennighausen, L., McKnight, R.A., Burdon, T., Baik, M., Smith, G.H and Wall, R.J. (1994) Whey acidic protein extrinsically from the mouse mammary tumor virus long terminal repeat results in hyperplasia of the coagulation gland epithelium and impaired mammary development. Cell Growth and Differentiation 5, 607-613.

8. McKnight, R.A., Shamay, A., Sankaran, L., Wall, R.J. and Hennighausen, L. (1992) Matrix attachment regions impart position independent regulation of a tissue specific gene in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 89, 6943-6947.

9. Shamay, A., Pursel, V., McKnight, R.A., Alexander, L., Beattie, C., Hennighausen, L., and Wall, R.J. (1991). Production of the whey acidic protein in transgenic pigs during lactation. J. Anim. Sci. 69, 4552-4562.

10. Wall, R.J., Pursel, V.G., Shamay, A., McKnight, R.A., Pittius, C.W., and Hennighausen, L. (1991). High-level synthesis of a heterologous milk protein in the mammary glands of transgenic swine. Proc. Natl. Acad. Sci. USA 88, 1696-1700.

11. Hennighausen, L., Shamay, A., Furth, P.A., McKnight, R.A., Rexroad, C.E. Jr, Pursel, V.G., and Wall, R.J. (1992) Transgenic animals as bioreactors for therapeutic and nutritional proteins. In E.F. Wagner and F. Theuring (eds.) Transgenic animals as model systems for human diseases, Springer Verlag, Berlin, 129-142.

12. McKnight, R.A., Burdon, T., Pursel, V.G., Shamay, A., Wall, R.J. and Hennighausen, L. (1991). The whey acidic protein. In R.B Dickson and M.E. Lippman (eds.) Breast Cancer: Molecular and Cellular Biology, Kluwer Academic Publishers, Boston, 399-412.

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