The Chronic Renal Diseases Program supports basic and clinical research on renal development and disease, including (1) causes, pathogenetic mechanisms, and pathophysiology; (2) morphological and functional markers and diagnostic measures; (3) underlying mechanisms leading to progression of renal disease; (4) functional adaptation to progressive nephron loss; (5) natural history of progressive renal diseases; and (6) identification and testing of possible therapeutic interventions to prevent development or halt progression of renal disease.
Research in this program includes the primary glomerulopathies and renal disease from systemic diseases that collectively account for more than 50 percent of all cases of treated end-stage renal disease.
Of special interest are studies of inherited diseases such as polycystic kidney disease, congenital kidney disorders, and immune-related glomerular diseases including IgA nephropathy and the hemolytic uremic syndrome.
For further information, contact: Dr. Michael Flessner, Program Director, Clinical Chronic Kidney Disease; Dr. Krystyna Rys-Sikora, Program Director, Basic Chronic Kidney Disease; Dr. Paul Eggers, Program Director, End-Stage Renal Disease; Dr. Paul Kimmel, Program Director, Kidney Translational Genetics; or Dr. John Kusek, Program Director, Kidney Clinical Trials.
