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tirapazamine
A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand name: | | Tirazone | |
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| Code names: | | SR 4233 WIN 59075 | |
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| Chemical structure: | | 3-amino-1,2,4-benzotriazine-1,4-dioxide | |
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