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thioguanine
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand names: | | Tabloid Tabloid brand thioguanine Tioguanine | |
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| Foreign brand names: | | Lanvis Tioguanin | |
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| Abbreviations: | | 6-TG TG | |
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| Code names: | | BW 5071 Wellcome U3B WR-1141 X 27 | |
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| Chemical structures: | | 2-Amino 6MP 2-Amino-1,7-dihydro-6H-purine-6-thione 2-Amino-6-mercaptopurine 2-Amino-6-purinethiol 2-Aminopurin-6-thiol 2-Aminopurine-6(1H)-thione 2-Aminopurine-6-thiol 6 Mercaptoguanine 6 Thioguanine 6H-Purine-6-thione, 2-amino-1,7-dihydro- (9CI) 6-Mercapto-2-aminopurine 6-mercaptoguanine 6-thioguanine | |
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