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vadimezan
A fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym: | Dimethyloxoxanthene Acetic Acid | ||
Abbreviations: | 5,6-MexXAA DMXAA | ||
Code names: | AS1404 ASA404 | ||
Chemical structure: | 5,6-Dimethylxanthenone-4-Acetic Acid | ||