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perillyl alcohol
A naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-translational protein farnesylation and isoprenylation and activation of oncoproteins such as p21-ras, and arresting tumor cells in the G1 phase of the cell cycle. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | dihydrocuminyl alcohol perilla alcohol perillic alcohol perillol | |
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| Abbreviation: | | POH | |
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| Chemical structures: | | (S)-(-)-perillyl alcohol 1-cyclohexene-1-methanol 4-(1-methylethenyl)-1-cyclohexene-1-methanol 4-isopropenylcyclohex-1-ene-1-methanol p-mentha-1,8-dien-7-ol | |
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