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recombinant modified vaccinia Ankara-5T4 vaccine
A cancer vaccine comprised of a recombinant modified vaccinia Ankara (MVA) viral vector encoding the 5T4 fetal oncoprotein (MVA-h5T4). Vaccination with recombinant modified vaccinia Ankara-5T4 vaccine may stimulate the host immune system to mount a humoral and cytotoxic T lymphocyte (CTL) response against tumor cells expressing 5T4 fetal oncoprotein antigen, resulting in tumor cell lysis. The MVA viral vector, derived from the replication-competent strain Ankara, is a highly attentuated, replication-defective vaccinia strain incapable of virion assembly. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | recombinant MVA-5T4 vaccine recombinant pox virus encoding 5T4 vaccine vaccinia-5T4 antigen vaccine | |
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| US brand name: | | TroVax | |
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| Foreign brand name: | | TroVax | |
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| Abbreviation: | | rV-5T4 VAC | |
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